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Alterations in l-arginine and inflammatory markers in type 2 diabetic patients with and without microalbuminuria

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Abstract

Low-grade inflammation is closely involved in the pathogenesis of type 2 diabetes and associated micro- and macrovascular complications. The nitric oxide (NO) precursor l-arginine, is relevant to diverse pathological conditions including type 2 diabetes and its complications. High sensitive-CRP (hs-CRP), neopterin and arginine levels were measured in 46 normoalbuminuric, 45 microalbuminuric type 2 diabetics and in 32 healthy controls in order to assess the relationship between markers of inflammation and l-arginine. Hs-CRP concentrations were higher in microalbuminuric diabetic patients compared to normoalbuminuric patients and controls. Diabetics had higher serum and urine neopterin levels than controls. Urine neopterin and l-arginine levels differed significantly among diabetic patients with and without microalbuminuria. There were significant positive correlations between hs-CRP and BMI in healthy controls and diabetics with and without microalbuminuria. In microalbuminuric diabetics, hs-CRP correlated with microalbuminuria (MAU). Significant predictors for the development of microalbuminuria were higher postprandial glucose levels, lower creatinine clearance and lower serum l-arginine levels. Assessment of early markers of inflammation and endothelial function, such as neopterin and NO precursor l-arginine, may help to predict incipient nephropathy more accurately in type 2 diabetic patients.

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Authors and Affiliations

  1. Department of Biochemistry, Ege University School of Medicine, Bornova, Izmir, Turkey

    Necla Barış, Ebru Sezer, A. Mert Özgönül, Nevbahar Turgan & Biltan Ersöz

  2. Department of Endocrinology, Ege University School of Medicine, Bornova, Izmir, Turkey

    Mehmet Erdoğan & Füsun Saygılı

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  1. Necla Barış
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  2. Mehmet Erdoğan
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  3. Ebru Sezer
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  4. Füsun Saygılı
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  5. A. Mert Özgönül
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  6. Nevbahar Turgan
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  7. Biltan Ersöz
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Correspondence to Nevbahar Turgan.

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Barış, N., Erdoğan, M., Sezer, E. et al. Alterations in l-arginine and inflammatory markers in type 2 diabetic patients with and without microalbuminuria. Acta Diabetol 46, 309–316 (2009). https://doi.org/10.1007/s00592-008-0089-9

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  • DOI: https://doi.org/10.1007/s00592-008-0089-9

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