Abstract
The aim of this study is to assess the prevalence and associated risk factors of lens opacities among type 2 diabetics in Kinmen, Taiwan. A community-based mass screening ascertained 971 type 2 diabetics from 1991 to 1993. From that population, a total of 578 (59.5%) patients with type 2 diabetes underwent eye screening in 1999 with a 45° thin slit-lamp biomicroscopy and ophthalmoscopy to examine the lens after dilation of the pupils. The prevalence of nuclear, cortical, and posterior subcapsular (PSC) opacity without surgery among type 2 diabetics was 22.5, 20.2, and 19.9%, respectively. The number of females affected was statistically higher than males in each type of lens opacity. The prevalence of each type of lens opacity also showed a statistically significant increase with (χ2 test). Based on multiple logistic regressions, age was the most significant factor related with each type of lens opacity. Triglyceride at baseline was associated with nuclear opacity (≥200 vs. <200 mg/dl, OR = 2.35, 95% CI: 1.15–4.79) and PSC opacity (≥200 vs. <200 mg/dl, OR = 2.11, 95% CI: 1.00–4.43). In conclusion, our results show that in addition to age, higher triglyceride level may increase the risk of prevalent nuclear or PSC opacity in type 2 diabetics.
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References
Klein R, Klein BEK, Moss SE (1984) Visual impairment in diabetes. Ophthalmology 91:1–8
Ederer F, Hiller R, Taylor HR (1981) Senile lens changes and diabetes in two population studies. Am J Ophthalmol 91:381–395
Klein BEK, Klein R, Moss MS (1985) Prevalence of cataracts in a population-based study of persons with diabetes mellitus. Ophthalmology 92:1191–1196
Steinberg EP, Tielsch JM, Schein OD et al (1994) The VF-14: an index of functional impairment in patients with cataract. Arch Ophthalmol 112:630–638
He M, Xu J, Li S et al (1999) Visual acuity and quality of life in patients with cataract in Doumen county, China. Ophthalmology 106:1609–1615
Zhao J, Sui R, Jia L et al (1998) Visual acuity and quality of life outcomes in patients with cataract in Shunyi county, China. Am J Ophthalmol 126:515–523
Klein BEK, Klein R, Lee KE (1998) Diabetes, cardiovascular disease, selected cardiovascular disease risk factors, and the 5-year incidence of age-related cataract and progression of lens opacities: the Beaver Dam Eye Study. Am J Ophthalmol 126:782–790
Tung TH, Liu JH, Lee FL et al (2005) Community-based study of cataracts among type 2 diabetics in Kinmen. Eur J Epidemiol 20:435–441
Tsai CY, Tung TH, Woung LC et al (2007) Population-based study of cataract surgery among patients with type 2 diabetes in Kinmen, Taiwan. Can J Ophthalmol 42:262–267
Chou P, Liao M J, Kuo HS et al (1994) A population survey on the prevalence of diabetes in Kin-Hu, Kinmen. Diabetes Care 17:1055–1058
World Health Organization (1999) Definition, diagnosis and classification of diabetes mellitus and its complications: report of a WHO consultation. Part 1. Diagnosis and classification of diabetes mellitus. World Health Organization, Geneva
Stratton IM, Alder AI, Neil HA et al (2000) Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 321:405–412
Early Treatment diabetic retinopathy study research group (1991) Early photocoagulation for diabetic retinopathy. ETDRS Report Number 9. Ophthalmology 98:766–785
Wilkinson CP, Ferris FL, Klein RE et al (2003) Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology 110:1677–1682
Tsai SY, Hsu WM, Cheng CY et al (2003) Epidemiologic study of age-related cataracts among an elderly Chinese population in Shihpai, Taiwan. Ophthalmology 110:1089–1095
Chylack LT Jr, Wolfe JK, Singer DM.et al (1993) The lens opacities classification system III. The longitudinal study of cataract study group. Arch Ophthalmol 111:831–836
Cheng CY, Liu JH, Chen SJ et al (2000) Population-based study on prevalence and risk factors of age-related cataracts in Peitou, Taiwan. Chin Med J (Taipei) 63:641–648
Mitchell P, Cumming RG, Attebo K et al (1997) Prevalence of cataract in Australia: the Blue Mountain eye study. Ophthalmology 104:581–588
Seah SKL, Wong TY, Foster PJ et al (2002) Prevalence of lens opacity in Chinese residents of Singapore: the Tanjong Pager survey. Ophthalmology 109:2058–2064
West SK, Valmadrid CT (1995) Epidemiology of risk factors for age-related cataract. Surv Ophthalmol 39:323–334
Wong TY, Klein R, Klein BEK et al (2001) Refractive errors and age-related cataract: the Beaver Dam Eye Study. Invest Ophthalmol Vis Sci 42:449–454
Leske MC, Chylack LT Jr, Wu SY (1991) The lens opacities case-control study group. The lens opacities case-control study. Risk factors for cataract. Arch Ophthalmol 109:244–251
Hammond CJ, Snieder H, Spector TD et al (2000) Genetic and environment factors in age-related nuclear cataracts in monozygotic and dizygotic twins. N Engl J Med 342:1786–1790
Chatterjee A, Milton RC, Thyle S (1982) Prevalence and aetiology of cataract in Punjab. Br J Ophthalmol 66:35–42
Klein BEK, Klein R, Ritter LL (1994) Is there evidence of an estrogen effect on age-related lens opacities? The Beaver Dam Eye study. Arch Ophthalmol 112:85–91
Kim SI, Kim SJ (2006) Prevalence and risk factors for cataracts in persons with type 2 diabetes mellitus. Korean J Ophthalmol 20:201–204
Klein BEK, Klein R, Moss SE (1995) Incidence of cataract surgery in the Wisconsin epidemiologic study of diabetic retinopathy. Am J Ophthalmol 119:295–300
Klein BEK, Klein R, Jensen SC et al (1995) Hypertension and lens opacities from the Beaver Dam Eye study. Am J Ophthalmol 119:640–646
Schaumberg DA, Glynn RJ, Christen WG et al (2001) A prospective study of blood pressure and risk of cataract in men. Ann Epidemiol 11:104–110
Leske MC, Chylack LT, He Q et al (1998) Risk factors for nuclear opalescence in a longitudinal study. LSC group. Longitudinal study of cataract. Am J Epidemiol 147:36–41
Hiller R, Sperduto RD, Ederer F (1986) Epidemiologic associations with nuclear, cortical, and posterior subcapsular cataracts. Am J Epidemiol 124:916–925
Mohan M, Sperduto RD, Angra SK et al (1989) India–US case-control study of age-related cataracts. Arch Ophthalmol 107:670–676
Chen TT, Hockwin O, Dobbs R et al (1988) Cataract and health status: a case-control study. Ophthalmic Res 20:1–9
Hiller R, Sperduto RD, Reed GF et al (2003) Serum lipids and age-related lens opacities: a longitudinal investigation. The Framingham studies. Ophthalmology 110:578–583
Janh CE, Janke M, Winowsk H et al (1986) Identification of metabolic risk factors for posterior subcapsular cataract. Ophthalmic Res 18:112–116
Tsutsumi K, Inoue Y, Yoshida C (1999) Acceleration of development of diabetic cataract by hyperlipidemia and low high density lipoprotein rats. Biol Pharm Bull 22:37–41
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This study was supported by the grants from the National Science Council (NSC-95-2314-B-350-002-MY3).
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Chen, SJ., Liu, JH., Shih, HC. et al. Prevalence and associated factors of lens opacities among Chinese type 2 diabetics in Kinmen, Taiwan. Acta Diabetol 45, 7–13 (2008). https://doi.org/10.1007/s00592-007-0012-9
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DOI: https://doi.org/10.1007/s00592-007-0012-9