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A comparison of outcomes for above-knee-amputation and arthrodesis for the chronically infected total knee arthroplasty: a systematic review

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European Journal of Orthopaedic Surgery & Traumatology Aims and scope Submit manuscript

Abstract

Introduction

Several strategies have been shown to have some efficacy in the chronically infected total knee arthroplasty (TKA): chronic antibiotic suppression, a second two-stage revision, arthrodesis, and above-the-knee amputation (AKA). We conducted a systematic review to determine the efficacy of these treatments in patients who had previously received a two-stage revision.

Methods

A systematic review of the literature was performed which investigated PubMed, Embase, Scopus, and Web of Science Databases. Chronic infection was defined as a persistent infection of a TKA after a previous two-stage revision. Studies were independently evaluated by two reviewers. Quality appraisal was performed using MINORS Criteria.

Results

14 studies were included for the final review. For chronically infected TKA, a second two-stage revision was often sufficient to control infection. If revision failed, the most common next procedure was either a repeat revision or AKA. AKA patients had less pain and higher quality of life scores compared to arthrodesis, but a higher five-year mortality rate.

Discussion and conclusion

Chronic infection in TKA offers a multitude of challenges for orthopedic surgeons. We found that arthrodesis and AKA were not significantly different in rates of infection eradication or quality of life. We recommend clinicians to actively discuss options with patients to find a procedure most suitable for them.

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Authors and Affiliations

  1. University of Illinois College of Medicine at Chicago, Chicago, IL, 60612, USA

    Michael C. Edgar, Ryan J. Alderman, Isabel M. Scharf, Sam H. Jiang, Max Davison-Kerwood & Luke Zabawa

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  1. Michael C. Edgar
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  2. Ryan J. Alderman
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  3. Isabel M. Scharf
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  4. Sam H. Jiang
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Correspondence to Michael C. Edgar.

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All authors declare that they have no conflicts of interest.

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All procedures performed in this study were in accordance with the ethical standards of the institution and have been approved by the appropriate ethics committee and have, therefore, been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Edgar, M.C., Alderman, R.J., Scharf, I.M. et al. A comparison of outcomes for above-knee-amputation and arthrodesis for the chronically infected total knee arthroplasty: a systematic review. Eur J Orthop Surg Traumatol 33, 2933–2941 (2023). https://doi.org/10.1007/s00590-023-03507-z

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