Skip to main content

Advertisement

SpringerLink
Log in

Magnetic resonance imaging of soft tissue sarcoma: features related to prognosis

  • General Review
  • Published:
European Journal of Orthopaedic Surgery & Traumatology Aims and scope Submit manuscript

Abstract

Magnetic Resonance Imaging is a fundamental tool in the evaluation of soft tissue sarcoma. Imaging features are relevant for the assessment of treatment strategies, surgical planning and also for patients’ prognosis prediction. Among soft tissue sarcoma and also other malignancies, the size of the mass is usually considered the prognostic key element in diagnostic imaging. Moreover, several other features should be obtained from MRI studies with prognostic implications in all type of soft tissue sarcoma: peritumoral enhancement, signs of necrosis, deep location, ill-defined borders/signs of infiltrations. Focusing on soft tissue sarcoma subtypes, some other magnetic resonance imaging features are more specific and related to prognosis. In myxofibrosarcoma the magnetic resonance imaging “tail sign” and a “water-like” appearance on fluid-sensitive sequences, due to rich myxoid matrix content, are both associated with higher risk of local recurrence after surgical excision; nevertheless, the “tail sign” is also related to a higher risk of distant metastases at diagnosis. The “tail sign” is associated with higher risk of local recurrence after surgical excision in undifferentiated pleomorphic sarcoma as well. In patients affected by synovial sarcoma, the “triple sign” identifiable in magnetic resonance imaging (T2w sequences) is associated with decreased disease-free survival and indicates the simultaneous presence of solid cellular elements (intermediate signal intensity), hemorrhage or necrosis (high signal intensity) and fibrotic regions (low signal intensity). In addition, absence of calcifications are associated with reduced disease-free survival in patients affected by synovial sarcoma. Signal heterogeneity is associated with worst prognosis in all type of soft tissue sarcoma, particularly in myxoid liposarcoma. In recent years, several new quantitative tools applied on magnetic resonance imaging have been proved to predict patients’ prognosis. Above all the new tools, radiomics seems to be one of the most promising, and, has been proved to have the capability in discriminating low-grade from high-grade soft tissue sarcomas. Therefore, magnetic resonance imaging studies in patients with soft tissue sarcoma should be accurately evaluated and their results should be taken into account for prognostic assessment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Trovik CS, Bauer HC, Alvegård TA, Anderson H, Blomqvist C, Berlin O, Gustafson P, Saeter G, Wallöe A (2000) Surgical margins, local recurrence and metastasis in soft tissue sarcomas: 559 surgically-treated patients from the Scandinavian sarcoma group register. Eur J Cancer 36(6):710–716. https://doi.org/10.1016/s0959-8049(99)00287-7

    Article  CAS  PubMed  Google Scholar 

  2. Hui JY (2016) Epidemiology and etiology of sarcomas. Surg Clin North Am 96(5):901–914. https://doi.org/10.1016/j.suc.2016.05.005

    Article  PubMed  Google Scholar 

  3. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61(2):69–90. https://doi.org/10.3322/caac.20107

    Article  PubMed  Google Scholar 

  4. Bolia IK, Savvidou OD, Kang HP, Chatzichristodoulou N, Megaloikonomos PD, Mitsiokapa E, Mavrogenis AF, Papagelopoulos PJ (2021) Cross-cultural adaptation and validation of the musculoskeletal tumor society (MSTS) scoring system and Toronto extremity salvage score (TESS) for musculoskeletal sarcoma patients in Greece. Eur J Orthop Surg Traumatol. https://doi.org/10.1007/s00590-021-02921-5

    Article  PubMed  PubMed Central  Google Scholar 

  5. Honoré C, Méeus P, Stoeckle E, Bonvalot S (2015) Soft tissue sarcoma in France in 2015: epidemiology, classification and organization of clinical care. J Visc Surg 152(4):223–230. https://doi.org/10.1016/j.jviscsurg.2015.05.001

    Article  PubMed  Google Scholar 

  6. Farid M, Ngeow J (2016) Sarcomas associated with genetic cancer predisposition syndromes: a review. Oncologist 21(8):1002–1013. https://doi.org/10.1634/theoncologist.2016-0079

    Article  PubMed  PubMed Central  Google Scholar 

  7. Lahat G, Lazar A, Lev D (2008) Sarcoma epidemiology and etiology: potential environmental and genetic factors. Surg Clin North Am 88(3):451–481. https://doi.org/10.1016/j.suc.2008.03.006

    Article  PubMed  Google Scholar 

  8. Choong PF, Gustafson P, Willén H, Akerman M, Baldetrop B, Fernö M, Alvegård T, Rydholm A (1995) Prognosis following locally recurrent soft-tissue sarcoma. A staging system based on primary and recurrent tumour characteristics. Int J Cancer 60(1):33–7. https://doi.org/10.1002/ijc.2910600104

    Article  CAS  PubMed  Google Scholar 

  9. Lee JH, Kim Y, Yoo HJ, Kim HS, Cho HS, Han I (2020) Prognoses of superficial soft tissue sarcoma: the importance of fascia-tumor relationship on MRI. Eur J Surg Oncol 46(2):282–287. https://doi.org/10.1016/j.ejso.2019.10.003

    Article  PubMed  Google Scholar 

  10. Oda Y, Yamamoto H, Kohashi K, Yamada Y, Iura K, Ishii T, Maekawa A, Bekki H (2017) Soft tissue sarcomas: from a morphological to a molecular biological approach. Pathol Int 67(9):435–446. https://doi.org/10.1111/pin.12565

    Article  CAS  PubMed  Google Scholar 

  11. Guo X, Jo VY, Mills AM, Zhu SX, Lee CH, Espinosa I, Nucci MR, Varma S, Forgó E, Hastie T, Anderson S, Ganjoo K, Beck AH, West RB, Fletcher CD, van de Rijn M (2015) Clinically relevant molecular subtypes in leiomyosarcoma. Clin Cancer Res 21(15):3501–3511

    Article  CAS  Google Scholar 

  12. Wortman JR, Tirumani SH, Jagannathan JP, Tirumani H, Shinagare AB, Hornick JL, Ramaiya NH (2016) Primary extremity liposarcoma: MRI features, histopathology, and clinical outcomes. J Comput Assist Tomogr 40(5):791–798. https://doi.org/10.1097/RCT.0000000000000431

    Article  PubMed  Google Scholar 

  13. WHO classification of tumours editorial board (2020) WHO classification of tumours of soft tissue and bone, 5th edn. IARC Press, Lyon

    Google Scholar 

  14. Martin-Liberal J (2013) Leiomyosarcoma: principles of management. Intractable Rare Dis Res 2(4):127–129. https://doi.org/10.5582/irdr.2013.v2.4.127

    Article  PubMed  PubMed Central  Google Scholar 

  15. Harati K, Daigeler A, Lange K, Niggemann H, Stricker I, Steinau HU, Lehnhardt M, Goertz O (2017) Somatic leiomyosarcoma of the soft tissues: a single-institutional analysis of factors predictive of survival in 164 patients. World J Surg 41(6):1534–1541. https://doi.org/10.1007/s00268-017-3899-5

    Article  PubMed  Google Scholar 

  16. Grossmann AH, Layfield LJ, Randall RL (2012) Classification, molecular characterization, and the significance of pten alteration in leiomyosarcoma. Sarcoma 2012:380896. https://doi.org/10.1155/2012/380896

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Ferrari A, Dileo P, Casanova M et al (2003) Rhabdo-myosarcoma in adults: a retrospective analysis of 171 patients treated at a single institution. Cancer 98:571–580

    Article  Google Scholar 

  18. Sambri A, Bianchi G, Cucurnia I, Gambarotti M, Donati DM (2018) Pediatric soft tissue sarcoma of the limbs: clinical outcome of 97 patients. Eur J Orthop Surg Traumatol 28(1):1–7. https://doi.org/10.1007/s00590-017-2019-4

    Article  PubMed  Google Scholar 

  19. Sultan I, Qaddoumi I, Yaser S, Rodriguez-Galin-do C, Ferrari A (2009) Comparing adult and pediatric rhabdomyosarcoma in the surveillance, epidemi-ology and end results program, 1973–2005: an analysis of 2600 patients. J Clin Oncol 27:3391–3397

    Article  Google Scholar 

  20. Thway K, Fisher C (2014) Synovial sarcoma: defining features and diagnostic evolution. Ann Diagn Pathol 18(6):369–380. https://doi.org/10.1016/j.anndiagpath.2014.09.002

    Article  PubMed  Google Scholar 

  21. Spinnato P, Sambri A, Fujiwara T et al (2020) Myxofibrosarcoma: clinical and prognostic value of MRI features. Curr Med Imaging. https://doi.org/10.2174/1573405616999200729152135 (Published online ahead of print, 2020 Jul 29)

    Article  Google Scholar 

  22. Roberts CC, Kransdorf MJ, Beaman FD, Adler RS, Amini B, Appel M et al (2016) ACR appropriateness criteria follow-up of malignant or aggressive musculoskeletal tumors. J Am Coll Radiol 13(4):389–400

    Article  Google Scholar 

  23. Del Grande F, Subhawong T, Weber K, Aro M, Mugera C, Fayad LM (2014) Detection of soft-tissue sarcoma recurrence: added value of functional MR imaging techniques at 3.0 T. Radiology 271(2):499–511. https://doi.org/10.1148/radiol.13130844

    Article  PubMed  Google Scholar 

  24. Hanna SL, Fletcher BD (1995) MR imaging of malignant soft-tissue tumors. Magn Reson Imaging Clin N Am 3(4):629–650

    Article  CAS  Google Scholar 

  25. Gerrand C, Athanasou N, Brennan B, Grimer R, Judson I, Morland B, Peake D, Seddon B, Whelan J (2016) UK guidelines for the management of bone sarcomas. Clin Sarcoma Res 6:7. https://doi.org/10.1186/s13569-016-0047-1

    Article  PubMed  PubMed Central  Google Scholar 

  26. Jaovisidha S, Suvikapakornkul Y, Woratanarat P, Subhadrabandhu T, Nartthanarung A, Siriwongpairat P (2010) MR imaging of fat-containing tumours: the distinction between lipoma and liposarcoma. Singap Med J 51(5):418–423

    CAS  Google Scholar 

  27. El Ouni F, Jemni H, Trabelsi A, Ben Maitig M, Arifa N, Ben Rhouma K, Ben Ayech M, Tlili K (2010) Liposarcoma of the extremities: MR imaging features and their correlation with pathologic data. Orthop Traumatol Surg Res 96(8):876–883. https://doi.org/10.1016/j.otsr.2010.05.010

    Article  PubMed  Google Scholar 

  28. Allen SD, Moskovic EC, Fisher C, Thomas JM (2007) Adult rhabdomyosarcoma: cross-sectional imaging findings including histopathologic correlation. AJR 189:371–377

    Article  Google Scholar 

  29. Jones BC, Sundaram M, Kransdorf MJ (1993) Synovial sarcoma: MR imaging findings in 34 patients. AJR Am J Roentgenol 161(4):827–830. https://doi.org/10.2214/ajr.161.4.8396848

    Article  CAS  PubMed  Google Scholar 

  30. van Rijswijk CSP, Hogendoorn PCW, Taminiau AHM, Bloem JL (2001) Synovial sarcoma: dynamic contrast-enhanced MR imaging features. Skelet radiology 30(1):25–30. https://doi.org/10.1007/s002560000295

    Article  Google Scholar 

  31. Yoo HJ, Hong SH, Kang Y et al (2014) MR imaging of myxofibrosarcoma and undifferentiated sarcoma with emphasis on tail sign; diagnostic and prognostic value. Eur Radiol 24(8):1749–1757. https://doi.org/10.1007/s00330-014-3181-2

    Article  PubMed  Google Scholar 

  32. Sambri A, Spinnato P, Bazzocchi A, Tuzzato GM, Donati D, Bianchi G (2019) Does pre-operative MRI predict the risk of local recurrence in primary myxofibrosarcoma of the extremities? Asia Pac J Clin Oncol 15(5):e181–e186. https://doi.org/10.1111/ajco.13161

    Article  PubMed  Google Scholar 

  33. Gustafson P, Akerman M, Alvegård TA, Coindre JM, Fletcher CD, Rydholm A, Willén H (2003) Prognostic information in soft tissue sarcoma using tumour size, vascular invasion and microscopic tumour necrosis-the SIN-system. Eur J Cancer 39(11):1568–1576. https://doi.org/10.1016/s0959-8049(03)00369-1

    Article  CAS  PubMed  Google Scholar 

  34. Spinnato P (2021) The Importance of accurate tumor measurements and staging in oncologic imaging: impact on patients’ health. Acad Radiol. https://doi.org/10.1016/j.acra.2021.01.012 (Published online ahead of print, 2021 Jan 16)

    Article  PubMed  Google Scholar 

  35. Zagars GK, Ballo MT, Pisters PW, Pollock RE, Patel SR, Benjamin RS, Evans HL (2003) Prognostic factors for patients with localized soft-tissue sarcoma treated with conservation surgery and radiation therapy: an analysis of 1225 patients. Cancer 97(10):2530–2543. https://doi.org/10.1002/cncr.11365

    Article  PubMed  Google Scholar 

  36. Stojadinovic A, Leung DH, Allen P, Lewis JJ, Jaques DP, Brennan MF (2002) Primary adult soft tissue sarcoma: time-dependent influence of prognostic variables. J Clin Oncol 20(21):4344–4352. https://doi.org/10.1200/JCO.2002.07.154

    Article  PubMed  Google Scholar 

  37. Maretty-Nielsen K (2014) Prognostic factors in soft tissue sarcoma. Dan Med J 61(11):B4957

    PubMed  Google Scholar 

  38. Tanaka K, Ozaki T (2019) New TNM classification (AJCC eighth edition) of bone and soft tissue sarcomas: JCOG bone and soft tissue tumor study group. Jpn J Clin Oncol 49(2):103–107. https://doi.org/10.1093/jjco/hyy157

    Article  PubMed  Google Scholar 

  39. Yoon S, Maki RG, Asare EA, Cooper K, Hornick JL, Lazar AJ et al (2017) Soft tissue sarcoma of the trunk and extremities. In: Amin M (ed) AJCC cancer staging manual, 8th edn. Springer, New York, pp 507–515

    Chapter  Google Scholar 

  40. Eilber FC, Rosen G, Nelson SD, Selch M, Dorey F, Eckardt J, Eilber FR (2003) High-grade extremity soft tissue sarcomas: factors predictive of local recurrence and its effect on morbidity and mortality. Ann Surg 237(2):218–226. https://doi.org/10.1097/01.SLA.0000048448.56448.70

    Article  PubMed  PubMed Central  Google Scholar 

  41. Spinnato P, Clinca R, Vara G et al (2020) MRI features as prognostic factors in myxofibrosarcoma: proposal of MRI grading system. Acad Radiol. https://doi.org/10.1016/j.acra.2020.08.018 (published online ahead of print, 2020 Sep 11)

    Article  PubMed  Google Scholar 

  42. Tateishi U, Hasegawa T, Beppu Y, Satake M, Moriyama N (2004) Synovial sarcoma of the soft tissues. J Comput Assist Tomogr 28(1):140–148. https://doi.org/10.1097/00004728-200401000-00024

    Article  PubMed  Google Scholar 

  43. Cates JMM (2018) The AJCC 8th edition staging system for soft tissue sarcoma of the extremities or trunk: a cohort study of the SEER database. J Natl Compr Canc Netw 16(2):144–152. https://doi.org/10.6004/jnccn.2017.7042

    Article  PubMed  Google Scholar 

  44. Crombé A, Marcellin PJ, Buy X et al (2019) Soft-tissue sarcomas: assessment of MRI features correlating with histologic grade and patient outcome. Radiology 291(3):710–721. https://doi.org/10.1148/radiol.2019181659

    Article  PubMed  Google Scholar 

  45. O’Sullivan PJ, Harris AC, Munk PL (2008) Radiological imaging features of non-uterine leiomyosarcoma. Br J Radiol 81(961):73–81. https://doi.org/10.1259/bjr/18595145

    Article  CAS  PubMed  Google Scholar 

  46. Gordon RW, Tirumani SH, Kurra V, Shinagare AB, Jagannathan JP, Hornick JL, Ramaiya NH (2014) MRI, MDCT features, and clinical outcome of extremity leiomyosarcomas: experience in 47 patients. Skelet Radiol 43(5):615–622. https://doi.org/10.1007/s00256-014-1823-8

    Article  Google Scholar 

  47. Ledoux P, Kind M, Le Loarer F et al (2019) Abnormal vascularization of soft-tissue sarcomas on conventional MRI: diagnostic and prognostic values. Eur J Radiol 117:112–119. https://doi.org/10.1016/j.ejrad.2019.06.007

    Article  PubMed  Google Scholar 

  48. Crombé A, Le Loarer F, Stoeckle E, Cousin S, Michot A, Italiano A, Buy X, Kind M (2018) MRI assessment of surrounding tissues in soft-tissue sarcoma during neoadjuvant chemotherapy can help predicting response and prognosis. Eur J Radiol 109:178–187. https://doi.org/10.1016/j.ejrad.2018.11.004

    Article  PubMed  Google Scholar 

  49. MacDermed DM, Miller LL, Peabody TD, Simon MA, Luu HH, Haydon RC, Montag AG, Undevia SD, Connell PP (2010) Primary tumor necrosis predicts distant control in locally advanced soft-tissue sarcomas after preoperative concurrent chemoradiotherapy. Int J Radiat Oncol Biol Phys 76(4):1147–53. https://doi.org/10.1016/j.ijrobp.2009.03.015

    Article  PubMed  Google Scholar 

  50. Monsky WL, Jin B, Molloy C, Canter RJ, Li CS, Lin TC, Borys D, Mack W, Kim I, Buonocore MH, Chaudhari AJ (2012) Semi-automated volumetric quantification of tumor necrosis in soft tissue sarcoma using contrast-enhanced MRI. Anticancer Res 32(11):4951–4961

    PubMed  PubMed Central  Google Scholar 

  51. Zhao F, Ahlawat S, Farahani SJ, Weber KL, Montgomery EA, Carrino JA, Fayad LM (2014) Can MR imaging be used to predict tumor grade in soft-tissue sarcoma? Radiology 272(1):192–201. https://doi.org/10.1148/radiol.14131871

    Article  PubMed  Google Scholar 

  52. Spinnato P, Clinca R (2021) MRI tail sign in soft-tissue sarcoma. Radiology 16:203877. https://doi.org/10.1148/radiol.2021203877

    Article  Google Scholar 

  53. Wilkerson BW, Crim JR, Hung M, Layfield LJ (2012) Characterization of synovial sarcoma calcification. AJR Am J Roentgenol 199(6):W730–W734. https://doi.org/10.2214/AJR.11.7342

    Article  PubMed  Google Scholar 

  54. Liang C, Mao H, Tan J, Ji Y, Sun F, Dou W, Wang H, Wang H, Gao J (2015) Synovial sarcoma: magnetic resonance and computed tomography imaging features and differential diagnostic considerations. Oncol Lett 9(2):661–666. https://doi.org/10.3892/ol.2014.2774

    Article  PubMed  Google Scholar 

  55. Murphey MD, Gibson MS, Jennings BT, Crespo-Rodríguez AM, Fanburg-Smith J, Gajewski DA (2006) From the archives of the AFIP: imaging of synovial sarcoma with radiologic-pathologic correlation. Radiographics 26(5):1543–1565. https://doi.org/10.1148/rg.265065084

    Article  PubMed  Google Scholar 

  56. Gimber LH, Montgomery EA, Morris CD, Krupinski EA, Fayad LM (2017) MRI characteristics associated with high-grade myxoid liposarcoma. Clin Radiol 72(7):613.e1-613.e6. https://doi.org/10.1016/j.crad.2017.01.016

    Article  CAS  Google Scholar 

  57. Barile A, Zugaro L, Catalucci A et al (2002) Soft tissue liposarcoma: histological subtypes MRI and CT findings. Radiol Med 104(3):140–149

    CAS  PubMed  Google Scholar 

  58. Qi J, Thakrar PD, Browning MB, Vo N, Kumbhar SS (2021) Clinical utilization of whole-body PET/MRI in childhood sarcoma. Pediatr Radiol 51(3):471–479. https://doi.org/10.1007/s00247-020-04834-7

    Article  PubMed  Google Scholar 

  59. Chodyla M, Demircioglu A, Schaarschmidt BM, Bertram S, Bruckmann NM, Haferkamp J, Li Y, Bauer S, Podleska L, Rischpler C, Forsting M, Herrmann K, Umutlu L, Grueneisen J (2021) Evaluation of 18F-FDG PET and DWI datasets for predicting therapy response of soft-tissue sarcomas under neoadjuvant isolated limb perfusion. J Nucl Med 62(3):348–353. https://doi.org/10.2967/jnumed.120.248260

    Article  CAS  PubMed  Google Scholar 

  60. Yan R, Hao D, Li J, Liu J, Hou F, Chen H, Duan L, Huang C, Wang H, Yu T (2021) Magnetic resonance imaging-based radiomics nomogram for prediction of the histopathological grade of soft tissue sarcomas: a two-center study. J Magn Reson Imaging. https://doi.org/10.1002/jmri.27532

    Article  PubMed  Google Scholar 

  61. Crombé A, Le Loarer F, Sitbon M, Italiano A, Stoeckle E, Buy X, Kind M (2020) Can radiomics improve the prediction of metastatic relapse of myxoid/round cell liposarcomas? Eur Radiol 30(5):2413–2424. https://doi.org/10.1007/s00330-019-06562-5

    Article  PubMed  Google Scholar 

Download references

Funding

No funding was received for conducting this study. The authors have no relevant financial or non-financial interests to disclose.

Author information

Authors and Affiliations

  1. Diagnostic and Interventional Radiology, IRCCS Istituto Ortopedico Rizzoli, Via GC Pupilli n 1, 40136, Bologna, Italy

    Giulia Scalas, Anna Parmeggiani, Claudia Martella, Giancarlo Facchini & Paolo Spinnato

  2. Orthopaedic Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

    Gianmarco Tuzzato & Giuseppe Bianchi

  3. Department of Radiology, Ospedale degli Infermi, Faenza, Italy

    Roberta Clinca

Authors
  1. Giulia Scalas
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anna Parmeggiani
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Claudia Martella
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gianmarco Tuzzato
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Giuseppe Bianchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Giancarlo Facchini
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Roberta Clinca
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Paolo Spinnato
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

All authors contributed to the study conception and design. The idea for the article was by Paolo Spinnato, literature search was performed by Anna Parmeggiani, Claudia Martella and Giulia Scalas, while Roberta Clinca, Gianmarco Tuzzato, Giancarlo Facchini and Giuseppe Bianchi critically revised the work. The first draft of the paper was written by Giulia Scalas and Paolo Spinnato. All authors read and approved the final manuscript. All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.

Corresponding author

Correspondence to Paolo Spinnato.

Ethics declarations

Conflict of interest

The authors have no conflict of interests to disclose.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Scalas, G., Parmeggiani, A., Martella, C. et al. Magnetic resonance imaging of soft tissue sarcoma: features related to prognosis. Eur J Orthop Surg Traumatol 31, 1567–1575 (2021). https://doi.org/10.1007/s00590-021-03003-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00590-021-03003-2

Keywords

Search

Navigation