Skip to main content

Advertisement

SpringerLink
Log in

How do vertebroplasty and kyphoplasty affect the quality of life of patients with multiple myeloma spinal metastasis?

  • Original Article
  • Published:
European Journal of Orthopaedic Surgery & Traumatology Aims and scope Submit manuscript

Abstract

Background

Metastatic spinal lesions are diseases that impair the quality of life and require early diagnosis and treatment. The count of spinal metastasis patients rises day by day. Increased life expectancy has increased the incidence of cancer, making metastases more observable. The aim of our study was to investigate how the quality of life is affected in the patient group with vertebral fracture due to spinal metastases of multiple myeloma and undergoing vertebroplasty and kyphoplasty.

Materials and methods

Forty-two patients with fracture due to spinal metastasis and adequate follow-up between the years of 2011 and 2018 were included in the study. Patients were listed according to their primary malignancy and metastases. The effect of vertebroplasty and kyphoplasty was investigated by evaluating preoperative and postoperative VAS and Oswestry Disability Index scores. All patients’ radiographic kyphosis angle, compression ratio and wedging index were calculated before operation and after operation.

Results

A total of 76 vertebrae were operated in 42 patients. Significant differences were found in the comparison of preoperative and postoperative quality of life according to VAS and Oswestry Disability Index scores in the patients undergoing vertebroplasty, kyphoplasty or both procedures after spinal metastases (VAS; p = 0.0001, ODI; p = 0.002/0.0001). There were statistically significant differences in preoperative local kyphosis angle, compression ratio and wedging index and post-op local kyphosis angle, compression ratio and wedging index (p = 0.001).

Conclusion

Vertebroplasty and kyphoplasty, minimally invasive procedures performed after spinal metastases, improve the quality of life of the patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

Reference

  1. Melton LJ III, Kyle R (2005) Fracture risk with multiple myeloma: a population-based study. Bone Miner Res 20:487–493

    Article  Google Scholar 

  2. Nelson Astur MM (2019) Balloon kyphoplasty in the treatment of neoplastic spine lesions: a systematic review. Global Spine J 9:348–356

    Article  Google Scholar 

  3. Fourney DR, Schomer D (2003) Percutaneous vertebroplasty and kyphoplasty for painful vertebral body fractures in cancer patients. J Neurosurg 98:21–30

    Article  Google Scholar 

  4. Anselmetti GC, Manca A, Tutton S et al (2013) Percutaneous vertebral augmentation assisted by PEEK implant in painful osteolytic vertebral metastasis involving the vertebral wall: experience on 40 patients. Pain Phys 16(4):E397–E404

  5. Kirkegaard AO, Sørensen T (2018) Percutaneous vertebroplasty is safe and effective for cancer-related vertebral compression fractures. Dan Med J 65(10):A5509-13

    Google Scholar 

  6. Mehdi A, Mansouri N (2019) Use of cement-augmented percutaneous pedicular screws in the management of multifocal tumoral spinal fractures. Asian Spine J 13:305–312

    Article  Google Scholar 

  7. Cho JH, Ha JK (2015) Patterns of treatment for metastatic pathological fractures of the spine: the efficacy of each treatment modality. Clin Orthop Surg 7:476–482

    Article  Google Scholar 

  8. Hirabayashi H, Ebara S (2003) Clinical outcome and survival after palliative surgery for spinal metastases: palliative surgery in spinal metastases. Cancer 97:476–84

    Article  Google Scholar 

  9. Kwon YM, Kim KS (2009) Survival rate and neurological outcome after operation for advanced spinal metastasis (Tomita's classification > or = type 4). Yonsei Med J 50:689–96

    Article  Google Scholar 

  10. Yamashita T, Aota Y (2008) Changes in physical function after palliative surgery for metastatic spinal tumor: association of the revised Tokuhashi score with neurologic recovery. Spine 33:2341–6

    Article  Google Scholar 

  11. Rao PJ, Thayaparan GK (2014) Minimally invasive percutaneous fixation techniques for metastatic spinal disease. Orthop Surgery 6:187–95

    Article  Google Scholar 

  12. Kim CH, Chung CK (2003) Less invasive palliative surgery for spinal metastases. J Surg Oncol 108:499–503

    Article  Google Scholar 

  13. Rastogi R, Patel T (2010) Vertebral augmentation for compression fractures caused by malignant disease. J Natl Compr Canc Netw 8:1095–102

    Article  Google Scholar 

  14. Park HY, Lee SH (2015) Minimally invasive option using percutaneous pedicle screw for instability of metastasis involving thoracolumbar and lumbar spine: a case series in a single center. J Korean Neurosurg Soc 57:100–107

    Article  CAS  Google Scholar 

  15. Kim CH, Chung CK (2013) Less invasive palliative surgery for spinal metastases. J Surg Oncol 108:499–513

    Article  Google Scholar 

  16. Frankel BM, Jones T (2007) Segmental polymethylmethacrylate- augmented pedicle screw fixation in patients with bone softening caused by osteoporosis and metastatic tumor involvement: a clinical evaluation. Neurosurgery 61:531–537

    Article  Google Scholar 

  17. Ha KY, Min CK (2015) Bone cement augmentation procedures for spinal pathologic fractures by multiple myeloma. J Korean Med Sci 30:88–94

    Article  Google Scholar 

  18. Lim BS, Chang UK (2009) Clinical outcomes after percutaneous vertebroplasty for pathologic compression fractures in osteolytic metastatic spinal disease. J Korean Neurosurg Soc 45:369–74

    Article  Google Scholar 

  19. Farrokhi MR, Nouraei H (2012) The efficacy of percutaneous vertebroplasty in pain relief in patients with pathological vertebral fractures due to metastatic spinal tumors. Iran Red Crescent Med J 14:523–30

    PubMed  PubMed Central  Google Scholar 

  20. Lane JM, Hong R (2004) Kyphoplasty enhances function and structural alignment in multiple myeloma. Clin Orthop 426:49–53

    Article  Google Scholar 

  21. Hentschel SJ, Burton AW (2005) Percutaneous vertebroplasty and kyphoplasty performed at a cancer center: refuting proposed contraindications. J Neurosurg Spine 2:436–440

    Article  Google Scholar 

  22. Bilsky MH, Lis E (1999) The diagnosis and treatment of metastatic spinal tumor. The Oncologist 4:459–469

    Article  CAS  Google Scholar 

  23. Zeifang F, Zahlten-Hinguranage A (2005) Long-term survival after surgical intervention for bone disease in multiple myeloma. Ann Oncol 16:222–227

    Article  CAS  Google Scholar 

  24. Health Quality Ontario (2016) Vertebral augmentation involving vertebroplasty or kyphoplasty for cancer-related vertebral compression fractures: an economic analysis. Ont Health Technol Assess Ser 16(12):1–34

Download references

Funding

No funding.

Author information

Authors and Affiliations

  1. Dr Ersin Arslan Education and Research Hospital Gaziantep, Gaziantep, Turkey

    Sezgin Bahadır Tekin

  2. Department of Orthopedic Surgery, Gaziantep University Hospital Gaziantep, Gaziantep, Turkey

    Burçin Karslı, Orhan Büyükbebeci, İbrahim Halil Demir, Alp Yekta Gökalp & Volkan Kılınçoğlu

Authors
  1. Sezgin Bahadır Tekin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Burçin Karslı
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Orhan Büyükbebeci
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. İbrahim Halil Demir
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Alp Yekta Gökalp
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Volkan Kılınçoğlu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sezgin Bahadır Tekin.

Ethics declarations

Conflict of interest

No conflict of interest.

Ethical approval

Ethical approval from Gaziantep University Institutional Reviewer Board.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tekin, S.B., Karslı, B., Büyükbebeci, O. et al. How do vertebroplasty and kyphoplasty affect the quality of life of patients with multiple myeloma spinal metastasis?. Eur J Orthop Surg Traumatol 30, 1447–1451 (2020). https://doi.org/10.1007/s00590-020-02721-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00590-020-02721-3

Search

Navigation