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Chondroblastoma in adult age

  • Andrea Angelini
  • Mohammad Hassani
  • Andreas F. Mavrogenis
  • Giulia Trovarelli
  • Carlo Romagnoli
  • Antonio Berizzi
  • Pietro RuggieriEmail author
Original Article • CHONDROBLASTOMA - TUMORS

Abstract

Purpose

Chondroblastoma (CB) is a rare benign tumor that occurs most commonly in the second decade of life. No studies on CB in adulthood have been reported. Our purposes were to report a single-institution experience on CB in adults and to discuss the clinical and imaging findings, type of treatment, oncologic and functional outcomes.

Patients and methods

All patients diagnosed and treated for CB from 1981 to 2014 were reviewed. The main inclusion criterion was patients above their 30 years of age at diagnosis. Clinical presentation, imaging, surgical treatment, complications and functional outcome were evaluated. Local recurrences were recorded.

Results

There were 15 males (65%) and 8 females (35%) with a mean age of 40 years (range 30–59 years). Tumor involved the small bones (talus, calcaneus, acromion, cuneiform, metatarsals) in 15 patients (65%) and the long bones in eight patients (35%). Treatment consisted of curettage only (6 cases), curettage plus phenol (13 cases), curettage plus radiotherapy (one patient with vertebral tumor), resection (two patients with CB of the acromion) and chopart amputation (one patient with a metatarsal tumor). At a mean follow-up of 8.4 years (range 3–30 years), twenty patients (87%) remained continuously disease-free, whereas three had local recurrences. None of the patients received chemotherapy.

Conclusion

This study confirms that the occurrence and outcome of adult patients with CB are similar with those affecting younger patients. The main difference consists of the involved bones; flat bones and short tubular bones of the foot, especially the talus and calcaneus, are most commonly involved as opposed to long tubular bones.

Level of evidence

Therapeutic study, level IV-1 (case series).

Keywords

Chondroblastoma Adults Benign tumors Treatment Curettage 

Notes

Compliance with ethical standards

Conflict of interest

None of the authors have any financial and personal relationships with other people or organizations that could inappropriately influence (bias) their work. Dr. Angelini, Dr. Hassani, Dr. Mavrogenis, Dr. Trovarelli, Dr. Romagnoli, Dr. Berizzi and Prof. Ruggieri have nothing to disclose.

Ethic committee statement

Each author certifies that the manuscript has been read and approved and that the manuscript represents honest work. The IRB approval has not been requested due to the retrospective nature of the study, according to the policy of Ethic Committee of our Institute.

References

  1. 1.
    Suneja R, Grimer RJ, Belthur M, Jeys L, Carter SR, Tillman RM et al (2005) Chondroblastoma of bone: long-term results and functional outcome after intralesional curettage. J Bone Joint Surg Br 87(7):974–978CrossRefPubMedGoogle Scholar
  2. 2.
    Davila JA, Amrami KK, Sundaram M, Adkins MC, Unni KK (2004) Chondroblastoma of the hands and feet. Skeletal Radiol 33(10):582–587CrossRefPubMedGoogle Scholar
  3. 3.
    Enneking WF, Campanacci M (1999) Bone and soft tissue tumors, 2nd edn. Piccin Nuova-Libraria, Padova, pp 247–264Google Scholar
  4. 4.
    Unni KK (1996) Dahlin’s bone tumors: general aspect and data on 11087 cases, 5th edn. Lippinccot-Raven, New York, p 47Google Scholar
  5. 5.
    Atalar H, Basarir K, Yildiz Y, Erekul S, Saglik Y (2007) Management of chondroblastoma: retrospective review of 28 patients. J Orthop Sci 12(4):334–340CrossRefPubMedGoogle Scholar
  6. 6.
    Ramappa AJ, Lee FY, Tang P, Carlson JR, Gebhardt MC, Mankin HJ (2000) Chondroblastoma of bone. J Bone Joint Surg Am 82:1140–1145CrossRefPubMedGoogle Scholar
  7. 7.
    Unni KK, Inwards CY, Bridge JA, Kindblom LG, Wold LE (2005) AFIP atlas of tumor pathology 4th series fascicle 2: tumors of the bones and joints. Am Regist Pathol Washington, DC, pp 99–104Google Scholar
  8. 8.
    Mirra JM, Picci P, Gold RH (1989) Osseous soft tissue tumors. In: Mirra JM (ed) Bone tumors: clinical, radiologic, and pathologic correlations. Lea & Febiger, Philadelphia, pp 1549–1586Google Scholar
  9. 9.
    Dorfman HD, Czerniak B (1998) Bone tumors. N Engl J Med 8(1998):1088–1089Google Scholar
  10. 10.
    Masui F, Ushigome S, Kamitani K, Asanuma K, Fujii K (2002) Chondroblastoma: a study of 11 cases. EJSO 28(8):869–874CrossRefPubMedGoogle Scholar
  11. 11.
    Bloem JL, Mulder JD (1985) Chondroblastoma: a clinical and radiological study of 104 cases. Skeletal Radiol 4(1):1–9CrossRefGoogle Scholar
  12. 12.
    Turcotte RE, Kurt AM, Sim FH, Unni KK, Mcleod RA (1993) Chondroblastoma. Hum Pathol 24(9):944–949CrossRefPubMedGoogle Scholar
  13. 13.
    Inwards CY (2007) Update on cartilage forming tumors of the head and neck. Head Neck Pathol 1(1):67–74CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Khalili K, White LM, Kandel RA, Wunder JS (1997) Chondroblastoma with multiple distant soft tissue metastases. Skeletal Radiol 26(8):493–496CrossRefPubMedGoogle Scholar
  15. 15.
    de Silva MC, Reid R (2003) Chondroblastoma: varied histologic appearance, potential diagnostic pitfalls, and clinicopathologic features associated with local recurrence. Ann Diagn Pathol 7(4):205–213CrossRefPubMedGoogle Scholar
  16. 16.
    Ilaslan H, Sundaram M, Unni KK (2003) Vertebral chondroblastoma. Skeletal Radiol 32(2):66–71CrossRefPubMedGoogle Scholar
  17. 17.
    Van Der Geest I, Van Noort MP, Schreuder HW, Pruszczynski M, De Rooy JW, Veth RP (2007) The cryosurgical treatment of chondroblastoma of bone: long-term oncologic and functional results. J Surg Oncol 96(3):230–234CrossRefPubMedGoogle Scholar
  18. 18.
    Rybak LD, Rosenthal DI, Wittig JC (2009) Chondroblastoma: radiofrequency ablation—alternative to surgical resection in selected cases 1. Radiology 251(2):599–604CrossRefPubMedGoogle Scholar
  19. 19.
    Lin PP, Thenappan A, Deavers MT, Lewis VO, Yasko AW (2005) Treatment and prognosis of chondroblastoma. Clin Orthop 438:103–109CrossRefPubMedGoogle Scholar
  20. 20.
    Lehner B, Witte D, Weiss S (2011) Clinical and radiological long-term results after operative treatment of chondroblastoma. Arch Orthop Trauma Surg 131(1):45–52CrossRefPubMedGoogle Scholar
  21. 21.
    Schajowicz F, Gallardo H (1970) Epiphyseal chondroblastoma of bone: a clinic-pathological study of sixty nine cases. J Bone Joint Surg Br 52:205–226PubMedGoogle Scholar
  22. 22.
    Ben Maitigue M, Osman W, Ouni F, Boughammoura H, Nawar N, Mtaoumi M et al (2012) Chondroblastoma of bone. Tunis Me 90(7):571–578Google Scholar
  23. 23.
    Garin IE, Wang EHM (2008) Chondroblastoma. J Orthop Surg 16(1):84–87CrossRefGoogle Scholar
  24. 24.
    Hong SM, Yk P, Ro JY (1999) Chondroblastoma of temporal bone: a clinicopathologic study of five cases. J Korean Med Sci 14:559–564CrossRefPubMedPubMedCentralGoogle Scholar
  25. 25.
    Murphey MD, Walker EA, Wilson AJ, Kransdorf MJ, Temple HT, Gannon FH (2003) Imaging of primary chondrosarcoma: radiologic–pathologic correlation. AFIP Archiv Radiogr 23(5):1245–1278Google Scholar
  26. 26.
    Gelderblom H, Hogendoorn PC, Dijkstra SD, Van Rijswijk CS, Krol AD, Taminiau AH, Bovee JV (2008) The clinical approach towards chondrosarcoma. Oncologist 13(3):320–329CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag France SAS 2017

Authors and Affiliations

  1. 1.Department of Orthopaedics and Orthopaedic OncologyUniversity of PadovaPaduaItaly
  2. 2.Department of Orthopaedic Surgery, Imam Reza HospitalMashhad University of Medical SciencesMashhadIran
  3. 3.First Department of Orthopaedics, School of MedicineNational and Kapodistrian University of AthensAthensGreece
  4. 4.Department of Orthopaedic OncologyIstituto Ortopedico RizzoliBolognaItaly

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