Metastatic bone disease from breast cancer: a review of minimally invasive techniques for diagnosis and treatment

  • Dimitrios FilippiadisEmail author
  • Andreas F. Mavrogenis
  • Argyro Mazioti
  • Konstantinos Palialexis
  • Panayiotis D. Megaloikonomos
  • Panayiotis J. Papagelopoulos
  • Alexis Kelekis
General Review • TUMORS - METASTASES


Skeletal-related events in patients with metastatic bone disease include intractable severe pain, pathologic fracture, spinal cord and nerve compression, hypercalcemia and bone marrow aplasia. In patients with breast cancer, the skeleton is the most frequent site for metastases. Treatment options for metastatic bone disease in these patients include bisphosphonates, chemotherapeutic agents, opioids, hormonal therapy, minimally invasive/interventional and surgical techniques. Interventional oncology techniques for breast cancer patients with bone metastases include diagnostic (biopsy) and therapeutic (palliative and curative) approaches. In the latter, percutaneous ablation, augmentation and stabilization are included. The purpose of this article is to describe the basic concepts of biopsy, ablation, embolization and peripheral skeleton augmentation techniques in patients with metastatic bone disease from breast carcinoma. The necessity for a tailored approach applying different techniques for different cases and locations will be addressed.


Breast cancer Metastatic bone disease Biopsy Ablation Augmentation Embolization 


Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag France 2017

Authors and Affiliations

  • Dimitrios Filippiadis
    • 1
    Email author
  • Andreas F. Mavrogenis
    • 2
  • Argyro Mazioti
    • 1
  • Konstantinos Palialexis
    • 1
  • Panayiotis D. Megaloikonomos
    • 2
  • Panayiotis J. Papagelopoulos
    • 2
  • Alexis Kelekis
    • 1
  1. 1.Second Department of Radiology, National and Kapodistrian University of Athens, School of MedicineAttikon University General HospitalAthensGreece
  2. 2.First Department of OrthopaedicsAttikon University General HospitalAthensGreece

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