False-positive synovial fluid alpha-defensin test in a patient with acute gout affecting a prosthetic knee

  • D. G. PartridgeEmail author
  • A. Gordon
  • R. Townsend


The alpha-defensin test has demonstrated promising results in studies evaluating it for the diagnosis of prosthetic joint infection. There are limited data in the literature regarding its use in patients with other inflammatory joint conditions, but a high specificity for infection has been reported. We describe a patient with a prosthetic knee joint, who had a positive alpha-defensin lateral flow assay but in whom subsequent results confirmed a diagnosis of acute gout with no evidence of infection.


Prosthetic joint infection Gout Alpha-defensin assay Joint aspirate Synovasure 


Compliance with ethical standards

Conflict of interest

None of the authors has any conflict of interest.


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Copyright information

© Springer-Verlag France 2017

Authors and Affiliations

  1. 1.Department of Microbiology, Sheffield Teaching Hospitals NHS Foundation TrustNorthern General HospitalSheffieldUK
  2. 2.Department of Orthopaedics, Sheffield Teaching Hospitals NHS Foundation TrustNorthern General HospitalSheffieldUK

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