Reconstruction of the proximal femur with a modular resection prosthesis

  • Teresa Calabró
  • Rupert Van Rooyen
  • Ilaria Piraino
  • Elisa Pala
  • Giulia Trovarelli
  • Georgios N. Panagopoulos
  • Panayiotis D. Megaloikonomos
  • Andrea Angelini
  • Andreas F. Mavrogenis
  • Pietro RuggieriEmail author
Original Article • HIP - MEGAPROSTHESIS



Various megaprostheses are currently available for reconstruction of the proximal femur after tumor resection. This study evaluates the survival and complications of a modular megaprosthesis for reconstruction of the proximal femur.

Materials and methods

We studied the medical files of 109 tumor patients (age range 16–86 years) who underwent proximal femoral reconstruction with the MRP® megaprosthesis from 2002 to 2011. There were 70 patients with metastases, 34 patients with bone sarcomas, and five patients with hematological malignancies; 82 were primary and 27 were revision reconstructions. Mean follow-up was 2.5 years; 31 patients had a minimum five-year follow-up. We evaluated the survival and function of the patients, and the survival and complications of the megaprostheses.


Survival was significantly higher for the patients with bone sarcomas compared to those with metastases and hematological malignancies. Mean MSTS functional score was similar between patients with bone sarcomas and those with hematological malignancies and metastases, and between patients with primary and those with revision reconstructions. Overall survival of the MRP® megaprostheses was 74 % at 5 and 9 years. Fourteen (13.6 %) major complications occurred at a mean period of 1.4 years (range 3 months to 4.5 years); these included infection (5.8 %), dislocation (3.9 %), local recurrence (2.9 %), and acetabular fracture (1 %).


MRP® megaprostheses are a valuable reconstruction option after tumor resection of the proximal femur.


Limb salvage Proximal femur Megaprosthetic reconstruction MRP® 


Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Institutional and/or National Research Committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag France 2016

Authors and Affiliations

  • Teresa Calabró
    • 1
  • Rupert Van Rooyen
    • 1
  • Ilaria Piraino
    • 1
  • Elisa Pala
    • 1
  • Giulia Trovarelli
    • 1
  • Georgios N. Panagopoulos
    • 2
  • Panayiotis D. Megaloikonomos
    • 2
  • Andrea Angelini
    • 1
  • Andreas F. Mavrogenis
    • 2
  • Pietro Ruggieri
    • 1
    Email author
  1. 1.Department of Orthopedics, Istituto Ortopedico RizzoliUniversity of BolognaBolognaItaly
  2. 2.First Department of OrthopaedicsAthens University Medical SchoolHolargos, AthensGreece

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