Rapid destructive arthritis of the hip revisited

  • Andreas F. MavrogenisEmail author
  • Dimitrios A. Flevas
  • Georgios N. Panagopoulos
  • Panayiotis Megaloikonomos
  • Vasilios Igoumenou
  • Christos Vottis
  • Vasilios Sakellariou
  • Vasilios Kontogeorgakos
General Review • HIP - ARTHRITIS


Rapid destructive arthritis of the hip is a rare entity with unknown pathogenesis and outcome. First described by Forestier in 1957, it is characterized by a rapidly progressive hip disease resulting in rapid destruction of both the femoral and acetabular aspects of the hip joint, with almost complete disappearance of the femoral head within a few months. Since the original description, case reports and small series have been reported, and many names have been proposed to describe the rapid destruction of the femoral head and occasionally the acetabulum. Initial presentation includes acute hip pain with the lack of radiographic evidence of joint destruction, rapidly progressing to complete vanishing of the proximal femur within a few months. This article summarizes the related literature aiming to present the current concepts for the diagnosis and treatment of rapid destructive arthritis of the hip.


Rapid progressive Hip arthritis Coxarthrosis 


Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


  1. 1.
    Forestier F (1957) Coxite rhumatismales subaigues et chnoniques. Thesis, ParisGoogle Scholar
  2. 2.
    Lequesne M, de Seze S, Amouroux J (1970) Rapidly destructive coxarthrosis. Rev Rhum Mal Osteoartic 37(11):721–733PubMedGoogle Scholar
  3. 3.
    Postel M, Kerboull M (1970) Total prosthetic replacement in rapidly destructive arthrosis of the hip joint. Clin Orthop Relat Res 72:138–144PubMedGoogle Scholar
  4. 4.
    Flik K, Vargas JH 3rd (2000) Rapidly destructive hip disease: a case report and review of the literature. Am J Orthop (Belle Mead NJ) 29(7):549–552Google Scholar
  5. 5.
    Lequesne M, Ray G (1989) Rapid idiopathic destructive coxarthrosis. Prospective etiologic study of 27 cases. Rev Rhum Mal Osteoartic 56(2):115–119PubMedGoogle Scholar
  6. 6.
    Rosenberg ZS, Shankman S, Steiner GC, Kastenbaum DK, Norman A, Lazansky MG (1992) Rapid destructive osteoarthritis: clinical, radiographic, and pathologic features. Radiology 182(1):213–216CrossRefPubMedGoogle Scholar
  7. 7.
    Bock GW, Garcia A, Weisman MH et al (1993) Rapidly destructive hip disease: clinical and imaging abnormalities. Radiology 186(2):461–466CrossRefPubMedGoogle Scholar
  8. 8.
    Della Torre P, Picuti G, Di Filippo P (1987) Rapidly progressive osteoarthritis of the hip. Ital J Orthop Traumatol 13(2):187–200PubMedGoogle Scholar
  9. 9.
    Danielsson LG (1993) Incidence and prognosis of coxarthrosis. 1964. Clin Orthop Relat Res 287:13–18PubMedGoogle Scholar
  10. 10.
    Ledingham J, Dawson S, Preston B, Milligan G, Doherty M (1993) Radiographic progression of hospital referred osteoarthritis of the hip. Ann Rheum Dis 52(4):263–267PubMedCentralCrossRefPubMedGoogle Scholar
  11. 11.
    Sugano N, Ohzono K, Nishii T et al (2001) Early MRI findings of rapidly destructive coxopathy. Magn Reson Imaging 1:47–50CrossRefGoogle Scholar
  12. 12.
    Batra S, Batra M, McMurtrie A, Sinha AK (2008) Rapidly destructive osteoarthritis of the hip joint: a case series. J Orthop Surg Res 3:3PubMedCentralCrossRefPubMedGoogle Scholar
  13. 13.
    Boutry N, Paul C, Leroy X, Fredoux D, Migaud H, Cotten A (2002) Rapidly destructive osteoarthritis of the hip: MR imaging findings. AJR Am J Roentgenol 179(3):657–663CrossRefPubMedGoogle Scholar
  14. 14.
    Mitrovic DR, Riera H (1992) Synovial, articular cartilage and bone changes in rapidly destructive arthropathy (osteoarthritis) of the hip. Rheumatol Int 12(1):17–22CrossRefPubMedGoogle Scholar
  15. 15.
    Bekki S (1991) The pathogenesis of rapidly destructive coxarthrosis. Nihon Seikeigeka Gakkai zasshi 65(9):720–730PubMedGoogle Scholar
  16. 16.
    Yamamoto T, Bullough PG (2000) The role of subchondral insufficiency fracture in rapid destruction of the hip joint: a preliminary report. Arthritis Rheum 43(11):2423–2427CrossRefPubMedGoogle Scholar
  17. 17.
    Watanabe W, Itoi E, Yamada S (2002) Early MRI findings of rapidly destructive coxarthrosis. Skeletal Radiol 31(1):35–38CrossRefPubMedGoogle Scholar
  18. 18.
    Davies M, Cassar-Pullicino VN, Darby AJ (2004) Subchondral insufficiency fractures of the femoral head. Eur Radiol 14(2):201–207CrossRefPubMedGoogle Scholar
  19. 19.
    Lawrance JA, Athanasou NA (1995) Rapidly destructive hip disease. Skeletal Radiol 24(8):639–641CrossRefPubMedGoogle Scholar
  20. 20.
    Komiya S, Inoue A, Sasaguri Y, Minamitani K, Morimatsu M (1992) Rapidly destructive arthropathy of the hip. Studies on bone resorptive factors in joint fluid with a theory of pathogenesis. Clin Orthop Relat Res 284:273–282PubMedGoogle Scholar
  21. 21.
    Solomon L, Schnitzler CM, Browett JP (1982) Osteoarthritis of the hip: the patient behind the disease. Ann Rheum Dis 41(2):118–125PubMedCentralCrossRefPubMedGoogle Scholar
  22. 22.
    Charrois O, Kahwaji A, Rhami M, Inoue K, Courpied JP (2002) Outcome after total hip arthroplasty performed for rapidly progressive hip destruction. Rev Chir Orthop Reparatrice Appar Mot 88(3):236–244PubMedGoogle Scholar
  23. 23.
    Motomura G, Yamamoto T, Nakashima Y, Shuto T, Jingushi S, Iwamoto Y (2006) Outcome of the contralateral hip in rapidly destructive arthrosis after total hip arthroplasty: a preliminary report. J Arthroplasty 21(7):1026–1031CrossRefPubMedGoogle Scholar
  24. 24.
    Kuo A, Ezzet KA, Patil S, Colwell CW Jr (2009) Total hip arthroplasty in rapidly destructive osteoarthritis of the hip: a case series. HSS J 5(2):117–119PubMedCentralCrossRefPubMedGoogle Scholar
  25. 25.
    Okano K, Aoyagi K, Enomoto H, Osaki M, Chiba K, Yamaguchi K (2014) Bone mineral density in patients with destructive arthrosis of the hip joint. J Bone Miner Metab 32(3):312–316CrossRefPubMedGoogle Scholar
  26. 26.
    Viana SL, Machado BB, Mendlovitz PS (2014) MRI of subchondral fractures: a review. Skeletal Radiol 43(11):1515–1527CrossRefPubMedGoogle Scholar
  27. 27.
    Pivec R, Johnson AJ, Harwin SF, Mont MA (2013) Differentiation, diagnosis, and treatment of osteoarthritis, osteonecrosis, and rapidly progressive osteoarthritis. Orthopedics 36(2):118–125CrossRefPubMedGoogle Scholar
  28. 28.
    Yamamoto T (2012) Subchondral insufficiency fractures of the femoral head. Clin Orthop Surg 4(3):173–180PubMedCentralCrossRefPubMedGoogle Scholar
  29. 29.
    Yamamoto T, Schneider R, Iwamoto Y, Bullough PG (2010) Bilateral rapidly destructive arthrosis of the hip joint resulting from subchondral fracture with superimposed secondary osteonecrosis. Skeletal Radiol 39(2):189–192CrossRefPubMedGoogle Scholar
  30. 30.
    Ikemura S, Yamamoto T, Motomura G, Nakashima Y, Mawatari T, Iwamoto Y (2010) MRI evaluation of collapsed femoral heads in patients 60 years old or older: differentiation of subchondral insufficiency fracture from osteonecrosis of the femoral head. AJR Am J Roentgenol 195(1):W63–W68CrossRefPubMedGoogle Scholar
  31. 31.
    Niimi R, Hasegawa M, Sudo A, Uchida A (2005) Rapidly destructive coxopathy after subchondral insufficiency fracture of the femoral head. Arch Orthop Trauma Surg 125:410–413CrossRefPubMedGoogle Scholar
  32. 32.
    Nishida K, Yamamoto T, Motomura G, Shuto T, Nakashima Y, Jingushi S, Iwamoto Y (2005) Early MRI findings of the acetabulum and femoral head in a dysplastic hip resulting in a rapid destruction of the hip joint. Arch Orthop Trauma Surg 125:567–570CrossRefPubMedGoogle Scholar
  33. 33.
    Seitz S, Zustin J, Amling M, Rüther W, Niemeier A (2014) Massive accumulation of osteoclastic giant cells in rapid destructive hip disease. J Orthop Res 32(5):702–708CrossRefPubMedGoogle Scholar
  34. 34.
    Mavrogenis AF, Zambirinis CP, Dimitriadis PA, Tsakanikas A, Papagelopoulos PJ (2010) Gorham-Stout disease. J Surg Orthop Adv 19(2):85–90PubMedGoogle Scholar
  35. 35.
    Ruggieri P, Montalti M, Angelini A, Alberghini M, Mercuri M (2011) Gorham-Stout disease: the experience of the Rizzoli Institute and review of the literature. Skeletal Radiol 40(11):1391–1397CrossRefPubMedGoogle Scholar
  36. 36.
    Kobayashi S, Eftekhar NS, Terayama K, Iorio R (1994) Risk factors affecting radiological failure of the socket in primary Charnley low friction arthroplasty. A 10- to 20-year followup study. Clin Orthop Relat Res 306:84–96PubMedGoogle Scholar

Copyright information

© Springer-Verlag France 2015

Authors and Affiliations

  • Andreas F. Mavrogenis
    • 1
    Email author
  • Dimitrios A. Flevas
    • 1
  • Georgios N. Panagopoulos
    • 1
  • Panayiotis Megaloikonomos
    • 1
  • Vasilios Igoumenou
    • 1
  • Christos Vottis
    • 1
  • Vasilios Sakellariou
    • 1
  • Vasilios Kontogeorgakos
    • 1
  1. 1.First Department of Orthopaedics, Athens University Medical SchoolATTIKON University General HospitalAthensGreece

Personalised recommendations