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Giant-cell reparative granuloma-like lesion in the femoral heads of rats during the early repair phase of osteonecrosis

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European Journal of Orthopaedic Surgery & Traumatology Aims and scope Submit manuscript

Abstract

We describe the unusual occurrence of giant-cell reparative granulomas in the rat. Cutting the ligamentum teres and incising the periosteum around the base of the femoral neck induced femoral capital necrosis. Giant-cell reparative granuloma-like lesions developed in ~0.8% of 366 rats during the early reparative stages of osteonecrosis. Resorption of the necrotic bone, hematopoietic tissue, and adipocytes was exceptionally widespread in these three rats. Overexpression of macrophage-fusing cytokines may account for the increased number of multinucleated giant cells, which on a plump stromal cell background imitate a giant-cell reparative granuloma of the bone.

Résumé

Description d’un développement inhabituel de granulome de réparation à cellules géantes chez le rat. La section du ligament rond et l’incision du périoste à la base du col fémoral induit le développement d’une nécrose de la tête fémorale. Un granulome de réparation à cellules géantes se développe chez 0,8% de 366 rats durant la phase précoce de réparation de l’ostéonécrose. Une résorption de l’os nécrosé, du tissu hématopoéïtique et des adipocytes étaient largement présent et à titre exceptionnel chez ces 3 rats. Une sur-expression de cytokines créatrices de macrophages doit compter pour expliquer le grand nombre de cellules géantes, qui dans un environnement de stroma graisseux imitent un granulome à cellules géantes de réparation osseuse.

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References

  1. Al-Saffar N, Revell PA (1994) Interleukin-1 production by activated macrophages surrounding loosened orthopaedic implants: a potential role in osteolysis. Br J Rheumatol 33:309–316

    CAS  PubMed  Google Scholar 

  2. Boss JH, Ish-Shalom Z, Misselevich I (1996) Foreign body granulomatous response to particulate bony debris. Vet Comp Orthop Trauma 9:119–125

    Google Scholar 

  3. Boss JH, Misselevich I (2001) Experimental avascular osteonecrosis. Cur Orthop 15:57–67

    Article  Google Scholar 

  4. De Souza PE, Paim JF, Cavalhais JN, Gomez RS (1999) Immunohistochemical expression of p53, MDM 2, Ki-67 and PCNA in central giant cell granuloma and giant cell tumor. J Oral Pathol Med 28:54–58

    PubMed  Google Scholar 

  5. El-Labban NG (1991) Intravascular fibrin thrombi and endothelial cell damage in central giant cell granuloma. J Oral Pathol Med 26:1–5

    Google Scholar 

  6. Itonaga I, Sabokbar A, Murray DW, Athanasou NA (2000) Effect of osteoprotegerin and osteoprotegerin ligand on osteoclast formation by arthroplasty membrane derived macro-phages. Ann Rheum Dis 59:26–31

    Article  CAS  PubMed  Google Scholar 

  7. Itonaga I, Schulze E, Burge PD, Gibbons CL, Ferguson D, Athanasou NA (2002) Phenotypic characterization of mononuclear and multinucleated cells of giant cell reparative granuloma of small bones. J Pathol 198:30–36

    Article  CAS  PubMed  Google Scholar 

  8. Levin D, Norman D, Zinman C, Misselevich I, Reis NR, Boss JH (1999) Osteoarthritis-like disorder in rats with vascular deprivation-induced necrosis of the femoral head. Pathol Res Prac 195:637–642

    CAS  Google Scholar 

  9. Maruno M, Yoshimine T, Kubo T, Hayakawa T (1997) A case of giant cell reparative granuloma of the petrous bone: demonstration of the proliferative component. Surg Neurol 48:64–68

    Google Scholar 

  10. Mobbs RJ, Gollapudi PR, Fuller JW, Dahlstrom JE, Chandran NK (2000) Intradiploic hematoma after skull fracture: Case report and literature review. Surg Neurol 54:87–91

    Article  CAS  PubMed  Google Scholar 

  11. Norman D, Reis D, Zinman C, Misselevich I, Boss JH (1998) Vascular deprivation-induced necrosis of the femoral head of the rat. An experimental model of avascular necrosis in the skeletally immature individual or Legg-Perthes disease. Int J Exp Path 79:173–181

    Article  CAS  Google Scholar 

  12. O’Malley M, Pogrel MA, Stewart JC, Silva RG, Regezi JA (1991) Central giant cell granulomas of the jaws: phenotype and proliferation-associated markers. J Oral Pathol Med 26:159–163

    Google Scholar 

  13. Ratner V, Dorfman HD (1990) Giant-cell reparative granuloma of the hand and foot bones. Clin Orthop 260:251–258

    PubMed  Google Scholar 

  14. Sabo E, Peskin B, Misselevich I, Zinman C, Levin D, Norman D, Reis DN, Boss JH (2001) Computer-assisted image analysis of the rat postosteonecrotic remodeled femoral head. Exp Molec Path 71:256–264

    Article  CAS  PubMed  Google Scholar 

  15. Trigo FJ, Leathers CW, Brobast DF (1983) A comparison of canine giant cell tumor and giant cell reparative granuloma of bone. Vet Pathol 20:215–222

    CAS  PubMed  Google Scholar 

  16. Winet H, Hsieh A, Bao JY (1998) Approaches to study of ischemia in bone. J Biomed Mater Res 43:410–421

    Google Scholar 

  17. Yamaguchi T, Dorfman HD (2001) Giant cell reparative granuloma: a comparative clinicopathologic study of lesions in gnathic and extragnathic sites. Int J Surg Pathol 9:189–200

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Bnai-Zion Medical Center, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, PO Box 4940, 31048, Haifa, Israel

    Jochanan H. Boss & Ines Misselevich

  2. Department of Orthopaedic Surgery B, Rambam Medical Center, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

    Doron Norman & Chaim Zinman

Authors
  1. Jochanan H. Boss
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  2. Ines Misselevich
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  3. Doron Norman
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  4. Chaim Zinman
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Correspondence to Jochanan H. Boss.

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Boss, J.H., Misselevich, I., Norman, D. et al. Giant-cell reparative granuloma-like lesion in the femoral heads of rats during the early repair phase of osteonecrosis. Eur J Orthop Surg Traumatol 14, 7–9 (2004). https://doi.org/10.1007/s00590-003-0119-9

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  • DOI: https://doi.org/10.1007/s00590-003-0119-9

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