Abstract.
Localization and expression of cartilage-derived morphogenetic protein (CDMP)-1 in tissues at the site of ossification of the ligamentum flavum (OLF) were examined by immunohistochemistry and in situ hybridization. The CDMP-1 protein and messenger ribonucleic acid (mRNA) were localized in spindle-shaped cells and chondrocytes in the OLF tissues. CDMP-1 was not detected in cells in non-ossified sites. These data indicate that CDMP-1 is locally activated and localized in spindle-shaped cells and chondrocytes at the site of OLF. Given the previously reported promoting action of CDMP-1 for chondrogenesis, the current results suggest that CDMP-1 may be involved in the progression of OLF, leading to the narrowing of spinal canal and thus causing severe clinical manifestations.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Electronic Publication
Rights and permissions
About this article
Cite this article
Nakase, T., Ariga, K., Yonenobu, K. et al. Activation and localization of cartilage-derived morphogenetic protein-1 at the site of ossification of the ligamentum flavum. Eur Spine J 10, 289–294 (2001). https://doi.org/10.1007/s005860100307
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s005860100307