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Differences in imaging and clinical characteristics are associated with higher rates of decompression-fusion versus decompression-alone in women compared to men for lumbar degenerative spondylolisthesis

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Abstract

Purpose

The goals were to ascertain if differences in imaging/clinical characteristics between women and men were associated with differences in fusion for lumbar degenerative spondylolisthesis.

Methods

Patients had preoperative standing radiographs, CT scans, and intraoperative fluoroscopic images. Symptoms and comorbidity were obtained from patients; procedure (fusion-surgery or decompression-alone) was obtained from intraoperative records. With fusion surgery as the dependent variable, men and women were compared in multivariable logistic regression models with clinical/imaging characteristics as independent variables. The sample was dichotomized, and analyses were repeated with separate models for men and women.

Results

For 380 patients (mean age 67, 61% women), women had greater translation, listhesis angle, lordosis, and pelvic incidence, and less diastasis and disc height (all p ≤ 0.03). The rate of fusion was higher for women (78% vs. 65%; OR 1.9, p = 0.008). Clinical/imaging variables were associated with fusion in separate models for men and women. Among women, in the final multivariable model, less comorbidity (OR 0.5, p = 0.05), greater diastasis (OR 1.6, p = 0.03), and less anterior disc height (OR 0.8, p = 0.0007) were associated with fusion. Among men, in the final multivariable model, opioid use (OR 4.1, p = 0.02), greater translation (OR 1.4, p = 0.0003), and greater diastasis (OR 2.4, p = 0.0002) were associated with fusion.

Conclusions

There were differences in imaging characteristics between men and women, and women were more likely to undergo fusion. Differences in fusion within groups indicate that decisions for fusion were based on composite assessments of clinical and imaging characteristics that varied between men and women.

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Funding

No external support received for this work. Approved by Institutional Review Board at Hospital for Special Surgery.

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Authors and Affiliations

  1. Hospital for Special Surgery, 535 E 70th St, New York, NY, 10021, USA

    Alex M. Fong, Roland Duculan, Yoshimi Endo, John A. Carrino, Frank P. Cammisa, Alexander P. Hughes, Darren R. Lebl, James C. Farmer, Russel C. Huang, Harvinder S. Sandhu, Carol A. Mancuso, Federico P. Girardi & Andrew A. Sama

  2. Weill Cornell Medical College, New York, NY, USA

    Carol A. Mancuso

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  1. Alex M. Fong
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  2. Roland Duculan
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  3. Yoshimi Endo
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  4. John A. Carrino
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  5. Frank P. Cammisa
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  6. Alexander P. Hughes
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  7. Darren R. Lebl
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  8. James C. Farmer
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  9. Russel C. Huang
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  10. Harvinder S. Sandhu
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  11. Carol A. Mancuso
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  12. Federico P. Girardi
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  13. Andrew A. Sama
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Correspondence to Carol A. Mancuso.

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Fong, A.M., Duculan, R., Endo, Y. et al. Differences in imaging and clinical characteristics are associated with higher rates of decompression-fusion versus decompression-alone in women compared to men for lumbar degenerative spondylolisthesis. Eur Spine J 32, 4184–4191 (2023). https://doi.org/10.1007/s00586-023-07958-0

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  • DOI: https://doi.org/10.1007/s00586-023-07958-0

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