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Scoliosis in osteogenesis imperfecta: results of posterior spinal fusion in 39 patients

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Abstract

Purpose

To evaluate the outcomes of scoliosis corrective surgery in Osteogenesis Imperfecta (OI) patients with primarily pedicles screw fixation in terms of correcting and maintaining the correction of the spinal deformity, and to assess for several peri-operative parameters and complications associated with this surgical treatment.

Methods

Retrospective case series of 39 consecutive patients with OI treated surgically for scoliosis. The surgeries were performed between 2002 and 2020 by three different surgeons. All patients’ medical peri-operative and post-operative charts were evaluated. Radiological assessment was performed by evaluation of the pre-operative, immediate post-operative and last follow-up plain radiographs.

Results

There were 20 females and 19 males included in this review with a mean age of 14 years (range, 6–20 years) at the time of surgery. The median follow-up time was 7.9 years. The mean pre-operative cobb angle (CA) of the major curve was 76.5 degrees (SD ± 18.9), decreasing to 42.6 (SD ± 17.4) in the long-term post-operative follow-up (P < 0.001). A total of 21 adverse events in 16 patients were noted. Only 4 patients required subsequent invasive surgical treatment or prolonged hospital stay. All other patients were treated conservatively with no lasting complication.

Conclusion

Scoliosis surgical correction in OI patients seems to yield acceptable results, with maintained coronal plane surgical correction in the long-term follow-up. Even though a high peri-operative complications rate is observed in this series, there were no long-term sequelae or lasting complications.

Level of Evidence

Level IV, Case series.

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Funding

This study was not funded. The authors have no relevant financial or non-financial interests to disclose. The study protocol was approved by the Shamir Medical Center institutional review board.

Author information

Authors and Affiliations

  1. McGill Scoliosis & Spine Centre, McGill University Health Centre, Montreal, Canada

    Oded Rabau, Neil Saran & Jean Ouellet

  2. Department of Orthopaedic Surgery, LSU Health Sciences Center, New Orleans, LA, USA

    Kumar Abhishek

  3. Spine Unit, Department of Orthopedic Surgery, Shamir (Assaf Harofeh) Medical Center, POB 2007, 48810, Kfar-Qassim, Zerifin, Israel

    Oded Rabau, Ahmad Essa, Yossi Smorgick & Yoram Anekstein

  4. Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Oded Rabau, Ahmad Essa, Yossi Smorgick & Yoram Anekstein

Authors
  1. Oded Rabau
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  2. Ahmad Essa
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  3. Yossi Smorgick
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  4. Yoram Anekstein
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  5. Kumar Abhishek
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  6. Neil Saran
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  7. Jean Ouellet
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Contributions

OR drafted the initial manuscript, carried out all statistical analyses, and approved the final manuscript as submitted. JO, NS, KA, AE, YA and YS conceptualized and designed the study, reviewed and revised the manuscript, and approved the final manuscript as submitted. OR and AE designed the data collection instruments, carried out the initial analysis, and approved the final manuscript as submitted. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.

Corresponding author

Correspondence to Ahmad Essa.

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The authors did not receive support from any organization for the submitted work.

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Rabau, O., Essa, A., Smorgick, Y. et al. Scoliosis in osteogenesis imperfecta: results of posterior spinal fusion in 39 patients. Eur Spine J 32, 1146–1152 (2023). https://doi.org/10.1007/s00586-023-07550-6

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  • DOI: https://doi.org/10.1007/s00586-023-07550-6

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