Abstract
Purpose
Paediatric intervertebral disc calcification (PIDC) is a rare disease, and its aetiology remains unknown. This study aimed to analyse the characteristics and clinical outcomes of patients with PIDC.
Methods
After applying the exclusion and inclusion criteria, 159 children diagnosed with PIDC were analysed at our hospital between January 2010 and November 2020. Patients’ demographic and clinical data were collected, such as sex, pain, duration time, physical examination, white blood cell count, erythrocyte sedimentation rate, C-reactive protein, and radiography, computed tomography, and magnetic resonance imaging findings. Patients were followed up for at least 6 months, and radiography or symptoms were evaluated. Fisher’s exact test or χ2-test was used for statistical analyses.
Results
One hundred and fifty-nine patients were ultimately followed up with for about 12.5 ± 5.8 months. There were 103 male and 56 female, with an average age of 6.08 ± 2.62 years (2 months to 12 years). A total of 109 patients had only one PIDC, 29 patients had two PIDCs, and 21 patients had multiple PIDCs. Thirty patients were found incidentally and were asymptomatic. A total of 106 patients had neck torticollis. Sixteen patients had IDC herniations, fifteen patients had posterior longitudinal ligament calcification, two patients had anterior longitudinal ligament calcification, and 17 patients had herniation of the vertebral canal. All patients underwent conservative treatment, and none underwent surgery. All patients’ symptoms resolved after either collar fixation or neck traction.
Conclusion
PIDC can be treated conservatively, even when accompanied by herniation, longitudinal ligament calcification, or clinical neck symptoms.
Level of Evidence
IV.
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References
Coppa V, Marinelli M, Martiniani M, Giacchetta AM, Gigante AP, Specchia N (2020) Pediatric intervertebral disc calcification: case series and systematic review of the literature. J Pediatr Orthop B 29(6):590–598
Dushnicky MJ, Okura H, Shroff M, Laxer RM, Kulkarni AV (2019) Pediatric idiopathic intervertebral disc calcification: single-center series and review of the literature. J Pediatr 206:212–216
Roberts S, Evans H, Trivedi J, Menage J (2006) Histology and pathology of the human intervertebral disc. J Bone Joint Surg Am 88(Suppl 2):10–14
Lu Z, Yong T, Wen Y, Yifei G et al (2013) Vesicle consisted of calcified core and intervening turbid fluid, a possible composition of calcification in intervertebral disc calcification in children. Med Hypotheses 81(3):503–505
Hristova GI, Jarzem P, Ouellet JA, Roughley PJ et al (2011) Calcification in human intervertebral disc degeneration and scoliosis. J Orthop Res 29(12):1888–1895
Girodias JB, Azouz EM, Marton D (1991) Intervertebral disk space calcification. A report of 51 children with a review of the literature. Pediatr Radiol 21(8):541–546
Yang HS, Chen DY, Yuan W, Yang LL, Tsai N, Lin QS (2010) Paresis associated with aconuresis caused by intervertebral disc calcification at c7-t1: a case report and review of the literature. Spine (Phila Pa 1976) 35(10):E434–E439
Chu J, Wang T, Pei S, Yin Z (2015) Surgical treatment for idiopathic intervertebral disc calcification in a child: case report and review of the literature. Childs Nerv Syst 31(1):123–127
El Demellawy D, Robison JG, Pollack IF, Green MD, Alper CM, Reyes-Múgica M (2013) Idiopathic intervertebral disc calcification in childhood: an atypical case of an uncommon entity for pediatric pathologists. Pediatr Dev Pathol 16(6):432–437
Sato K, Nagata K, Park JS (2005) Calcified intervertebral disc herniation in a child with myelopathy treated with laminoplasty. Spinal Cord 43(11):680–683
He B, Nan G, Wang Z, Su Y, Qin J (2015) Idiopathic intervertebral disc calcification in a child: an atypical case involving many segments. JBJS Case Connect 5(4):e101
Spapens N, Wouters C, Moens P (2010) Thoracolumbar intervertebral disc calcifications in an 8-year-old boy: case report and review of the literature. Eur J Pediatr 169(5):577–580
Zhu J, Sun K, Xu X, Sun J et al (2019) A preliminary attempt of nonintervention in the treatment of patients with intervertebral disc calcification combined with ossification of the posterior longitudinal ligament. World Neurosurg 129:181–185
Wang G, Kang Y, Chen F, Wang B (2016) Cervical intervertebral disc calcification combined with ossification of posterior longitudinal ligament in an-11-year old girl: case report and review of literature. Childs Nerv Syst 32(2):381–386
Mizukawa K, Kobayashi T, Yamada N, Hirota T (2017) Intervertebral disc calcification with ossification of the posterior longitudinal ligament. Pediatr Int 59(5):622–624
Cuevas Y, Schonhaut L, Espinoza A, Schonstedt V, Aird A, Castoldi F (2015) Pediatric intervertebral disc calcification: a rare cause of acquired torticollis. Case report Rev Chil Pediatr 86(3):200–205
Du JJ, Meng H, Cao YJ, Li FQ, Luo ZJ (2012) Calcification of the intervertebral disc and posterior longitudinal ligament in children. J Spinal Disord Tech 25(1):59–63
Du JJ, Chen YF, Peng Y, Li XJ, Ma W (2018) Calcification of the intervertebral disc and ossification of posterior longitudinal ligament in children. BMC Musculoskelet Disord 19(1):316
Li CH, Lui TH, Ngai WK (2016) Acute calcification of intervertebral disc and posterior longitudinal ligament in a 7-year-old girl: a case report. J Orthop Surg (Hong Kong) 24(3):424–426
Dai LY, Ye H, Qian QR (2004) The natural history of cervical disc calcification in children. J Bone Joint Surg Am 86(7):1467–1472
O'Dell MC, Flores M, Murray JV Jr (2016) Pediatric idiopathic intervertebral disc calcification. Pediatr Neurol 61:115–116
Tsutsumi S, Yasumoto Y, Ito M (2011) Idiopathic intervertebral disk calcification in childhood: a case report and review of literature. Childs Nerv Syst 27(7):1045–1051
Dönmez H, Mavili E, Ikizceli T, Koç RK (2008) Pediatric intervertebral disc calcification. Diag Interv Radiol 14(4):225–227
Fu Z, Shi J, Jia L Jr, Yuan W Jr, Guan Z (2011) Intervertebral thoracic disc calcification associated with ossification of posterior longitudinal ligament in an eleven-year-old child. Spine (Phila Pa 1976) 36(12):E808–E810
Mahlfeld K, Kayser R, Grasshoff H (2002) Permanent thoracic myelopathy resulting from herniation of a calcified intervertebral disc in a child. J Pediatr Orthop B 11(1):6–9
Acknowledgements
Thanks to Hanjun Wu in our Medical Record Department for data collection.
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YS conceived the study, participated in its design and drafted the manuscript. XC and KC helped in collecting the clinical data and help drafted the manuscript. All authors read and approved the final manuscript.
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Chen, K., Chen, X. & Su, Y. Is conservative treatment a good choice for pediatric intervertebral disc calcification in children?. Eur Spine J 31, 3324–3329 (2022). https://doi.org/10.1007/s00586-022-07417-2
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DOI: https://doi.org/10.1007/s00586-022-07417-2