Skip to main content

Advertisement

SpringerLink
Log in

A 2-year longitudinal study of skeletal muscle mass in women over 40 years of age with degenerative lumbar scoliosis

  • Original Article
  • Published:
European Spine Journal Aims and scope Submit manuscript

Abstract

Purpose

We investigated changes in skeletal muscle mass and bone mineral density in degenerative lumbar scoliosis (DLS) patients during a 2-year follow-up following diagnosis.

Method

This study included 418 Japanese women, identifying 50 patients for the DLS group (mean age 76.4 years) and 368 patients for the control group (mean age 73.4 years). Whole-body skeletal muscle mass was measured using a Bioelectrical Impedance Analyzer. Bone mineral density (BMD) was measured using DXA. Skin autofluorescence (SAF), a marker of advanced glycation end products in the skin, was measured using a spectroscope. Spinal alignment, skeletal muscle mass, BMD, grip strength, and SAF were examined and the amount of change 1 and 2 years from the initial examination for each item was compared between groups.

Results

Height, body fat mass, grip strength, upper limb muscle mass, and trunk muscle mass in the DLS group were significantly lower, and lumbar spine BMD was significantly greater compared to controls at the first visit (p < 0.05). There was no significant difference in spinal alignment in the DLS group after 2 years compared with baseline. Trunk muscle mass also decreased significantly more in the DLS group (–2.7%) than in the control group (–1.1%) over the 2-year follow-up (p < 0.05).

Discussion

In this study, trunk muscle mass in the DLS group decreased about 2.4 times more in 2 years compared with the control group (p < 0.05). It may be possible to clarify the mechanism of kyphoscoliosis progression in the future with large-scale longitudinal studies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. World Health Organisation (2018) Ageing and Health, https:// www.who.int/news-room/fact-sheets/detail/ageing-and-health. Accessed 23 Jan 2019

  2. Takemitsu Y, Harada Y, Iwahara T, Miyamoto M, Miyatake Y (1988) Lumbar degenerative kyphosis. clinical, radiological and epidemiological studie (Phila Pa 1976). Spine. 13(11):1317–26

    Article  CAS  Google Scholar 

  3. Aebi M (2005) The adult scoliosis. Eur Spine J 14(10):925–948

    Article  Google Scholar 

  4. Glassman SD, Bridwell K, Dimar JR, Horton W, Berven S, Schwab F (2005) The impact of positive sagittal balance in adult spinal deformity. Spine 30(18):2024–2029

    Article  Google Scholar 

  5. Lafage V, Schwab F, Patel A, Hawkinson N, Farcy JP (2009) Pelvic tilt and truncal inclination: two key radiographic parameters in the setting of adults with spinal deformity. Spine 34(17):E599-606

    Article  Google Scholar 

  6. Schwab F, Ungar B, Blondel B, Buchowski J, Coe J, Deinlein D, DeWald C, Mehdian H, Shaffrey C, Tribus C, Lafage V (2012) Scoliosis research society-schwab adult spinal deformity classification: a validation study. Spine 37(12):1077–1082

    Article  Google Scholar 

  7. Ploumis A, Liu H, Mehbod AA, Transfeldt EE, Winter RB (2009) A Correlation of radiographic and functional measurements in adult degenerative scoliosis. Spine 34(15):1581–1584

    Article  Google Scholar 

  8. Saito M, Marumo K (2010) Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus. Osteoporos Int 21(2):195–214

    Article  CAS  Google Scholar 

  9. Pokharna HK, Phillips FM (1998) Collagen crosslinks in human lumbar intervertebral disc aging. Spine 23(15):1645–1648

    Article  CAS  Google Scholar 

  10. Duance VC, Crean JK, Sims TJ, Avery N, Smith S, Menage J, Eisenstein SM, Roberts S (1998) Changes in collagen cross-linking in degenerative disc disease and scoliosis. Spine 23(23):2545–2551

    Article  CAS  Google Scholar 

  11. Haus JM, Carrithers JA, Trappe SW, Trappe TA (2007) Collagen, cross-linking, and advanced glycation end products in aging human skeletal muscle. J Appl Physiol (1985). 103(6):2068–2076

    Article  CAS  Google Scholar 

  12. Eguchi Y, Toyoguchi T, Inage K, Fujimoto K, Orita S, Yamauchi K, Suzuki M, Kanamoto H, Abe K, Norimoto M, Umimura T, Koda M, Furuya T, Aoki Y, Takahashi K, Ohtori S (2018) Pentosidine concentration is associated with degenerative lumbar scoliosis in older women: preliminary results. Eur Spine J 27:597–606

    Article  Google Scholar 

  13. Meerwaldt R, Hartog JW, Graaff R, Huisman RJ, Links TP, den Hollander NC, Thorpe SR, Baynes JW, Navis G, Gans RO, Smit AJ (2005) Skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products, predicts mortality in hemodialysis patients. J Am Soc Nephrol 16(12):3687–3693

    Article  CAS  Google Scholar 

  14. Eguchi Y, Toyoguchi T, Inage K, Fujimoto K, Orita S, Suzuki M, Kanamoto H, Abe K, Norimoto M, Umimura T, Sato T, Koda M, Furuya T, Aoki Y, Nakamura J, Akazawa T, Takahashi K, Ohtori S (2019) Analysis of skeletal muscle mass in women over 40 with degenerative lumbar scoliosis. Eur Spine J 28(7):1618–1625

    Article  Google Scholar 

  15. Yagi M, Hosogane N, Watanabe K, Asazuma T, Matsumoto M; Keio Spine Research Group (2016) The paravertebral muscle and psoas for the maintenance of global spinal alignment in patient with degenerative lumbar scoliosis. Spine J 16(4):451–458

    Article  Google Scholar 

  16. Hori Y, Hoshino M, Inage K, Miyagi M, Takahashi S, Ohyama S, Suzuki A, Tsujio T, Terai H, Dohzono S, Sasaoka R, Toyoda H, Kato M, Matsumura A, Namikawa T, Seki M, Yamada K, Habibi H, Salimi H, Yamashita M, Yamauchi T, Furuya T, Orita S, Maki S, Shiga Y, Inoue M, Inoue G, Fujimaki H, Murata K, Kawakubo A, Kabata D, Shintani A, Ohtori S, Takaso M, Nakamura H (2019) ISSLS Prize in clinical science 2019: clinical importance of trunk muscle mass for low back pain, spinal balance, and quality of life-a multicenter cross-sectional study. Eur Spine J 28(5):914–921

    Article  Google Scholar 

  17. Eguchi Y, Toyoguchi T, Inage K, Fujimoto K, Orita S, Suzuki M, Kanamoto H, Abe K, Norimoto M, Umimura T, Koda M, Furuya T, Aoki Y, Nakamura J, Akazawa T, Takahashi K, Ohtori S (2019) Advanced glycation end products are associated with sarcopenia in older women: aging marker dynamics. J Women Aging. 33:1–13

    Google Scholar 

  18. Kang CH, Shin MJ, Kim SM, Lee SH, Lee CS (2007) MRI of paraspinal muscles in lumbar degenerative kyphosis patients and control patients with chronic low back pain. Clin Radiol 62(5):479–486

    Article  CAS  Google Scholar 

  19. Shafaq N, Suzuki A, Matsumura A, Terai H, Toyoda H, Yasuda H, Ibrahim M, Nakamura H (2012) Asymmetric degeneration of paravertebral muscles in patients with degenerative lumbar scoliosis. Spine 37(16):1398–1406

    Article  Google Scholar 

  20. Xie D, Zhang J, Ding W, Yang S, Yang D, Ma L, Zhang J (2019) Abnormal change of paravertebral muscle in adult degenerative scoliosis and its association with bony structural parameters. Eur Spine J 28(7):1626–1637

    Article  Google Scholar 

  21. Kim H, Lee CK, Yeom JS, Lee JH, Cho JH, Shin SI, Lee HJ, Chang BS (2013) Asymmetry of the cross-sectional area of paravertebral and psoas muscle in patients with degenerative scoliosis. Eur Spine J 22(6):1332–1338

    Article  Google Scholar 

  22. Enomoto M, Ukegawa D, Sakaki K, Tomizawa S, Arai Y, Kawabata S, Kato T, Yoshii T, Shinomiya K, Okawa A (2012) Increase in paravertebral muscle activity in lumbar kyphosis patients by surface electromyography compared with lumbar spinal canal stenosis patients and healthy volunteers. J Spinal Disord Tech 25(6):E167–E173

    Article  Google Scholar 

  23. Liu G, Peacock M, Eilam O, Dorulla G, Braunstein E, Johnston CC (1997) Effect of osteoarthritis in the lumbar spine and hip on bone mineral density and diagnosis of osteoporosis in elderly men and women. Osteoporos Int 7(6):564–569

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. Masaya Mizutani, Yawara Eguchi are equally contributed.

Authors and Affiliations

  1. Department of Orthopaedic Surgery, Center for Orthopaedic science medical innovation, Graduated School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan

    Masaya Mizutani, Yawara Eguchi, Sumihisa Orita, Kazuhide Inage, Yasuhiro Shiga, Takeo Furuya, Satoshi Maki, Junichi Nakamura, Shigeo Hagiwara & Seiji Ohtori

  2. Department of Orthopaedic Surgery, Shimoshizu National Hospital, Shikawatashi, Yotsukaido, Chiba, 934-5284-0003, Japan

    Yawara Eguchi

  3. Department of Orthopaedic Surgery, Chiba Qiball Clinic, 4-5-1, Chuo-ku, Chiba, 260-0013, Japan

    Toru Toyoguchi

  4. Chiba University Center for Frontier Medical Engineering, 1-33 Yayoi-cho, CFME room#B201, Inage-ku, Chiba, 263-8522, Japan

    Sumihisa Orita

  5. Department of Orthopaedic Surgery, Eastern Chiba Medical Center, 3-6-2, Okayamadai, Togane, Chiba, 283-8686, Japan

    Yasuchika Aoki & Masahiro Inoue

  6. Department of Orthopedic Surgery, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-City, Ibaraki, 305-8575, Japan

    Masao Koda & Hiroshi Takahashi

  7. Department of Orthopaedic Surgery, St. Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-ku, Kawasaki, Kanagawa, 216-8511, Japan

    Tsutomu Akazawa

  8. Biostatistics Section, Clinical Research Center, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8677, Japan

    Yuki Shiko & Yohei Kawasaki

Authors
  1. Masaya Mizutani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yawara Eguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Toru Toyoguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sumihisa Orita
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kazuhide Inage
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yasuhiro Shiga
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Takeo Furuya
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Satoshi Maki
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Junichi Nakamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Shigeo Hagiwara
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Yasuchika Aoki
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Masahiro Inoue
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Masao Koda
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Hiroshi Takahashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Tsutomu Akazawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Yuki Shiko
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. Yohei Kawasaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  18. Seiji Ohtori
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yawara Eguchi.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mizutani, M., Eguchi, Y., Toyoguchi, T. et al. A 2-year longitudinal study of skeletal muscle mass in women over 40 years of age with degenerative lumbar scoliosis. Eur Spine J 31, 1158–1165 (2022). https://doi.org/10.1007/s00586-021-07038-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00586-021-07038-1

Keywords

Search

Navigation