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Non-coding RNAs in ossification of spinal ligament

European Spine Journal volume 30, pages 801–808 (2021)Cite this article

Abstract

Purpose

Ossification of the spinal ligament (OSL) is a disease characterized by progressive ectopic ossification or calcification in the tissues of spinal ligament. The molecular pathogenesis of OSL has not been clearly elucidated. Recently, ncRNAs was found to functionally participate in OSL development. This review summarized current knowledge regarding the deregulation and function of ncRNAs in OSL

Methods

Relevant studies on deregulation and function of ncRNAs in OSL were retrieved from the PubMed databases. Then, studies were manually selected for inclusion based on predefined criteria.

Result

14 studies were reviewed, with 4 studies about high throughput sequencing and microarray of ncRNAs, 8 studies relevant to the function of ncRNAs and 2 studies regarding the ncRNAs as the biomarker of OSL.

Conclusion

ncRNA play a vital role in the ossification of spinal ligament fibrocyte, including cell osteogenesis and inflammation. ncRNAs also have potential clinical utilities as therapeutic targets, risk predication and early detection in the management of OSL.

Level of Evidence I

Diagnostic: individual cross-sectional studies with the consistently applied reference standard and blinding.

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Figure 1.

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Acknowledgments

We thank Mitchell Arico from Liwen Bianji, Edanz Group China (www.liwenbianji.cn/ac), for editing the English text of a draft of this manuscript.

Funding

The manuscript submitted does not contain information about medical device(s)/durg(s). This study was funded by National Natural Science Foundation of China (81772375) No relevant financial activities outside the submitted word.

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Author notes

  1. Xiaoqiu Yuan and Lei Shi have contributed equally.

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  1. Spine Center, Department of Orthopaedics, Changzheng Hospital, Second Military, Medical University, No. 415 Fengyang Rd, Shanghai, 20003, China

    Xiaoqiu Yuan, Lei Shi & Yu Chen

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  1. Xiaoqiu Yuan
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Correspondence to Yu Chen.

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Yuan, X., Shi, L. & Chen, Y. Non-coding RNAs in ossification of spinal ligament. Eur Spine J 30, 801–808 (2021). https://doi.org/10.1007/s00586-020-06687-y

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  • DOI: https://doi.org/10.1007/s00586-020-06687-y

Keywords

  • Non-coding RNA
  • microRNA
  • Long non-coding RNA
  • Circular RNA
  • Osteogenesis
  • Ossification of spinal ligament