Patients with ankylosing spondylitis treatment by golimumab: a systematic review and meta-analysis

Abstract

Purpose

The goal of this study was to review relevant randomized controlled trials in order to determine the clinical efficacy of golimumab in the treatment of ankylosing spondylitis (AS).

Methods

Using appropriate keywords, we identified relevant studies using PubMed, Cochrane and Embase. Key pertinent sources in the literature were also reviewed, and all articles published through November 2019 were considered for inclusion. For each study, we assessed odds ratios, mean difference and 95% confidence interval to assess and synthesize outcomes.

Results

We included nine studies with 6363 patients. Compared with placebo, golimumab would significant decreased the value of BASFI, BASMI, BASDAI, total back pain, JSEQ; increased the value of SF-36 PCS and SF-36 MCS; increased the incidence of BASDAI50, ASAS20, ASAS40 and ASAS partial remission. Compared with golimumab 50 mg, golimumab 100 mg would significantly decreased the value of BASFI and total back pain; increased the value of SF-36 PCS and SF-36 MCS; but also increased the incidence of SAE.

Conclusions

Golimumab had a definite effect in the treatment of AS. The higher dose would obtain better efficacy but lead to the incidence of SAE.

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Data availability

The data sets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Abbreviations

AS:

Ankylosing spondylitis

ORs:

Odds ratios

MD:

Mean difference

CI:

Confidence interval

BASFI:

Bath ankylosing spondylitis functional index

BASMI:

Bath ankylosing spondylitis metrology index

BASDAI:

Bath ankylosing spondylitis disease activity index

ASDAS:

Ankylosing spondylitis disease activity score

JSEQ:

Jenkins sleep evaluation questionnaire

AE:

Adverse event

SAE:

Serious adverse event

FDA:

Food and drug administration

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SAJ, SJ & BSR: Substantial contributions to conception and design. All authors: Data acquisition, data analysis and interpretation. All authors: Drafting the article or critically revising it for important intellectual content. All authors: Final approval of the version to be published. SJ & ZZ: Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of the work are appropriately investigated and resolved.

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Correspondence to Jiandang Shi.

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Sayed Abdulla, J., Shi, J., Roy, B.S. et al. Patients with ankylosing spondylitis treatment by golimumab: a systematic review and meta-analysis. Eur Spine J 29, 1813–1822 (2020). https://doi.org/10.1007/s00586-020-06466-9

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Keywords

  • Golimumab
  • Ankylosing spondylitis
  • Meta-analysis