Abstract
Purpose
The goal of this study was to review relevant randomized controlled trials in order to determine the clinical efficacy of golimumab in the treatment of ankylosing spondylitis (AS).
Methods
Using appropriate keywords, we identified relevant studies using PubMed, Cochrane and Embase. Key pertinent sources in the literature were also reviewed, and all articles published through November 2019 were considered for inclusion. For each study, we assessed odds ratios, mean difference and 95% confidence interval to assess and synthesize outcomes.
Results
We included nine studies with 6363 patients. Compared with placebo, golimumab would significant decreased the value of BASFI, BASMI, BASDAI, total back pain, JSEQ; increased the value of SF-36 PCS and SF-36 MCS; increased the incidence of BASDAI50, ASAS20, ASAS40 and ASAS partial remission. Compared with golimumab 50 mg, golimumab 100 mg would significantly decreased the value of BASFI and total back pain; increased the value of SF-36 PCS and SF-36 MCS; but also increased the incidence of SAE.
Conclusions
Golimumab had a definite effect in the treatment of AS. The higher dose would obtain better efficacy but lead to the incidence of SAE.
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Data availability
The data sets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Change history
14 February 2022
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1007/s00586-022-07129-7
Abbreviations
- AS:
-
Ankylosing spondylitis
- ORs:
-
Odds ratios
- MD:
-
Mean difference
- CI:
-
Confidence interval
- BASFI:
-
Bath ankylosing spondylitis functional index
- BASMI:
-
Bath ankylosing spondylitis metrology index
- BASDAI:
-
Bath ankylosing spondylitis disease activity index
- ASDAS:
-
Ankylosing spondylitis disease activity score
- JSEQ:
-
Jenkins sleep evaluation questionnaire
- AE:
-
Adverse event
- SAE:
-
Serious adverse event
- FDA:
-
Food and drug administration
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SAJ, SJ & BSR: Substantial contributions to conception and design. All authors: Data acquisition, data analysis and interpretation. All authors: Drafting the article or critically revising it for important intellectual content. All authors: Final approval of the version to be published. SJ & ZZ: Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of the work are appropriately investigated and resolved.
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This article has been retracted. Please see the retraction notice for more detail:https://doi.org/10.1007/s00586-022-07129-7
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Sayed Abdulla, J., Shi, J., Roy, B.S. et al. RETRACTED ARTICLE: Patients with ankylosing spondylitis treatment by golimumab: a systematic review and meta-analysis. Eur Spine J 29, 1813–1822 (2020). https://doi.org/10.1007/s00586-020-06466-9
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DOI: https://doi.org/10.1007/s00586-020-06466-9