Analysis of skeletal muscle mass in women over 40 with degenerative lumbar scoliosis
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We investigated the involvement of sarcopenia in middle-aged and elderly women with degenerative lumbar scoliosis (DLS).
A total of 971 women (mean age 70.4 years) were included in our study. These included 87 cases of DLS (mean 73.8 years) and 884 controls (69.8). Lumbar and femur BMD was measured for all participants using dual-energy X-ray absorptiometry. We used a bioelectrical impedance analyzer to analyze body composition, including appendicular skeletal muscle mass index (SMI; appendicular lean mass (kg)/(height (m))2. We determined bone density and skeletal muscle mass in both groups and determined the prevalence of sarcopenia. We examined the correlation between bone density and appendicular muscle mass in both groups. We also examined factors related to scoliosis using logistic regression analysis.
The DLS group showed significantly higher lumbar BMD, lower femur BMD, lower lean mass arm, and lower lean mass leg, and lower lean mass trunk (p < 0.05). Sarcopenia prevalence (SMI < 5.75) was 59.8% in DLS subjects and 42.8% in controls, revealing a high prevalence in DLS (p < 0.05). In both groups, lumbar and femur BMD were positively correlated with appendicular muscle mass. By logistic regression analysis, trunk muscle mass was detected as a risk factor for DLS independent of age (p < 0.05).
In middle-aged and elderly women, prevalence of sarcopenia was 59.8% in DLS cases and 42.8% in controls, which revealed a high prevalence in DLS. A decrease in trunk muscle was a significant risk factor for DLS that was independent of age.
KeywordsDegenerative lumbar scoliosis Sarcopenia Skeletal muscle mass Bioelectrical impedance analyzer
YE conducted data collection and data entry, performed the statistical analysis, and wrote the manuscript. TT developed data collection and participated in the design of the study and performed the statistical analysis. All authors contributed to and approved the final manuscript.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no competing interests. We did not receive grants or external funding in support of our research or preparation of this manuscript. We did not receive payments or other benefits or a commitment or agreement to provide such benefits from any commercial entities.
Human and animal rights statement
We declare that all protocols involving humans have been performed in accordance with the ethical standards of the institutional committee laid down in the 1964 Declaration of Helsinki and its later amendments. We declare that all participants provided written informed consent before their inclusion in this study.
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