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Mesenchymal stem cells derived from vertebrae (vMSCs) show best biological properties

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Abstract

Purpose

Due to their properties and characteristics human mesenchymal stem cells (MSCs) appear to have great therapeutic potential. Many different populations of MSCs have been described and to understand whether they have equivalent biological properties is a critical issue for their therapeutic application.

Methods

We proposed to analyze the in vitro growth kinetics of MSCs derived from different body sites (iliac crest bone marrow, vertebrae bone marrow, colon mucosa, dental pulp).

Results

Mesenchymal stem cells derived from vertebrae can be maintained in culture for a greater number of steps and they also generate mature cells of all mesenchymal lineages with greater efficiency, when induced into osteogenic, adipogenic and chondrogenic differentiation.

Conclusions

The ability of vertebrae-derived MSCs in terms of expansion and differentiation is very interesting at the light of a clinical application for bone fusion in spine surgery.

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Acknowledgments

The authors thank Carlo Piovani for his technical assistance in providing bone marrow samples during surgery at Maggiore Hospital and Rizzoli Orthopedics Institute, Bologna, Italy.

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Department of Oncological and Degenerative Spine Surgery, Rizzoli Orthopedics Institute, Via G.C. Pupilli, 40136, Bologna, Italy

    Giovanni Barbanti Brodano, Silvia Terzi, Cristiana Griffoni & Stefano Boriani

  2. Institute of Biomedical Technologies, National Research Council (CNR), Pisa, Italy

    Maria Cristina Magli

  3. Hematology Division, Department of Oncology, Transplants and New Advances in Medicine, University of Pisa, Pisa, Italy

    Luisa Trombi

  4. Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

    Mauro Valtieri

Authors
  1. Giovanni Barbanti Brodano
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  2. Silvia Terzi
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  3. Luisa Trombi
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  4. Cristiana Griffoni
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  5. Mauro Valtieri
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  6. Stefano Boriani
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  7. Maria Cristina Magli
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Corresponding author

Correspondence to Giovanni Barbanti Brodano.

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Barbanti Brodano, G., Terzi, S., Trombi, L. et al. Mesenchymal stem cells derived from vertebrae (vMSCs) show best biological properties. Eur Spine J 22 (Suppl 6), 979–984 (2013). https://doi.org/10.1007/s00586-013-3028-6

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  • DOI: https://doi.org/10.1007/s00586-013-3028-6

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