European Spine Journal

, Volume 21, Issue 12, pp 2659–2663 | Cite as

The effect of omega-3 fatty-acid supplements on perioperative bleeding following posterior spinal arthrodesis

  • Dennis S. Meredith
  • Christopher K. Kepler
  • Brandon Hirsch
  • Joseph Nguyen
  • James C. Farmer
  • Federico P. Girardi
  • Patrick F. O’Leary
  • Frank P. Cammisa
Original Article



To investigate the effect of omega-3 fatty-acid supplements (n-3FA) on bleeding during posterior spinal arthrodesis.


We reviewed all one- or two-level posterolateral lumbar decompression/fusions with or without interbody fusion by five surgeons within 3 years. Patients taking n-3FA preoperatively were matched 1:2 with controls based on procedure, surgeon and operative time. Patients with abnormal coagulation parameters, known bleeding disorders or other medications that could affect surgical blood loss were excluded.


Twenty-eight patients met inclusion criteria. The n-3FA and control groups were similar with respect to gender, age, body mass index, operative time, and preoperative use of non-steroidal anti-inflammatory drugs. The n-3FAs were stopped an average of 5.2 days before surgery (range 1–10). Mean estimated blood loss (EBL) was 697 ml in the n-3FA group and 771 ml in the control group (p = 0.36). Mean transfused volume of Cell Saver (CS) was 282 ml in the n-3FA group and 321 ml in the control group (p = 0.30). A post hoc power analysis showed that the study was powered to detect a minimum difference of 105 ml for EBL and 50 ml for CS. The multivariate generalized estimating equation did not show a significant difference between groups for EBL or CS (p = 0.35 and p = 0.29, respectively). Secondary outcomes including drop in postoperative hemoglobin, transfusion requirement, complications and surgical drain output were similar between the two groups.


The n-3FA use did not contribute to higher perioperative blood loss during spinal arthrodesis.


Omega-3 fatty acids Bleeding Spinal arthrodesis 


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Dennis S. Meredith
    • 1
  • Christopher K. Kepler
    • 2
  • Brandon Hirsch
    • 3
  • Joseph Nguyen
    • 1
  • James C. Farmer
    • 1
  • Federico P. Girardi
    • 1
  • Patrick F. O’Leary
    • 1
  • Frank P. Cammisa
    • 1
  1. 1.Department of Orthopedic SurgeryHospital for Special SurgeryNew YorkUSA
  2. 2.Department of Orthopedic Surgery, Rothman InstituteThomas Jefferson UniversityPhiladelphiaUSA
  3. 3.Department of Orthopedic SurgeryUniversity of MiamiMiamiUSA

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