Skip to main content
SpringerLink
Log in

Comparing effects of kyphoplasty, vertebroplasty, and non-surgical management in a systematic review of randomized and non-randomized controlled studies

European Spine Journal volume 21, pages 1826–1843 (2012)Cite this article

Abstract

Purpose

To determine if differences in safety or efficacy exist between balloon kyphoplasty (BKP), vertebroplasty (VP) and non-surgical management (NSM) for the treatment of osteoporotic vertebral compression fractures (VCFs).

Methods

As of February 1, 2011, a PubMed search (key words: kyphoplasty, vertebroplasty) resulted in 1,587 articles out of which 27 met basic selection criteria (prospective multiple-arm studies with cohorts of ≥20 patients). This systematic review adheres to preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines.

Results

Pain reduction in both BKP (−5.07/10 points, P < 0.01) and VP (−4.55/10, P < 0.01) was superior to that for NSM (−2.17/10), while no difference was found between BKP/VP (P = 0.35). Subsequent fractures occurred more frequently in the NSM group (22 %) compared with VP (11 %, P = 0.04) and BKP (11 %, P = 0.01). BKP resulted in greater kyphosis reduction than VP (4.8º vs. 1.7°, P < 0.01). Quality of life (QOL) improvement showed superiority of BKP over VP (P = 0.04), along with a trend for disability improvement (P = 0.08). Cement extravasation was less frequent in the BKP (P = 0.01). Surgical intervention within the first 7 weeks yielded greater pain reduction than VCFs treated later.

Conclusions

BKP/VP provided greater pain relief and fewer subsequent fractures than NSM in osteoporotic VCFs. BKP is marginally favored over VP in disability improvement, and significantly favored in QOL improvement. BKP had a lower risk of cement extravasation and resulted in greater kyphosis correction. Despite this analysis being restricted to Level I and II studies, significant heterogeneity suggests that the current literature is delivering inconsistent messages and further trials are needed to delineate confounding variables.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

USD 39.95

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Abbreviations

VCF(s):

Vertebral compression fracture(s)

BKP:

Balloon kyphoplasty

VP:

Vertebroplasty

VAPs:

Vertebral augmentation procedures

NSM:

Non-surgical management

RCT(s):

Randomized controlled trial(s)

PRISMA:

Preferred reporting items for systematic reviews and meta-analyses

ITC:

Indirect treatment comparisons

RMD:

Rolland morris disability

ODI:

Oswestry disability index

QOL:

Quality of life

PCS:

Physical component summary

VAS:

Visual analog scale

SAE(s):

Serious adverse event(s)

References

  1. Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17(12):1726–1733. doi:10.1007/s00198-006-0172-4

    Article  PubMed  CAS  Google Scholar 

  2. Lyles KW, Gold DT, Shipp KM, Pieper CF, Martinez S, Mulhausen PL (1993) Association of osteoporotic vertebral compression fractures with impaired functional status. Am J Med 94(6):595–601

    Article  PubMed  CAS  Google Scholar 

  3. Kado DM, Duong T, Stone KL, Ensrud KE, Nevitt MC, Greendale GA, Cummings SR (2003) Incident vertebral fractures and mortality in older women: a prospective study. Osteoporos Int 14(7):589–594. doi:10.1007/s00198-003-1412-5

    Article  PubMed  CAS  Google Scholar 

  4. Borgstrom F, Zethraeus N, Johnell O, Lidgren L, Ponzer S, Svensson O, Abdon P, Ornstein E, Lunsjo K, Thorngren KG, Sernbo I, Rehnberg C, Jonsson B (2006) Costs and quality of life associated with osteoporosis-related fractures in Sweden. Osteoporos Int 17(5):637–650. doi:10.1007/s00198-005-0015-8

    Article  PubMed  Google Scholar 

  5. Silverman SL (1992) The clinical consequences of vertebral compression fracture. Bone 13(Suppl 2):S27–S31

    Article  PubMed  Google Scholar 

  6. Schlaich C, Minne HW, Bruckner T, Wagner G, Gebest HJ, Grunze M, Ziegler R, Leidig-Bruckner G (1998) Reduced pulmonary function in patients with spinal osteoporotic fractures. Osteoporos Int 8(3):261–267

    Article  PubMed  CAS  Google Scholar 

  7. Lindsay R, Silverman SL, Cooper C, Hanley DA, Barton I, Broy SB, Licata A, Benhamou L, Geusens P, Flowers K, Stracke H, Seeman E (2001) Risk of new vertebral fracture in the year following a fracture. JAMA 285(3):320–323 (pii: joc02244)

    Article  PubMed  CAS  Google Scholar 

  8. Wardlaw D, Cummings SR, Van Meirhaeghe J, Bastian L, Tillman JB, Ranstam J, Eastell R, Shabe P, Talmadge K, Boonen S (2009) Efficacy and safety of balloon kyphoplasty compared with non-surgical care for vertebral compression fracture (FREE): a randomised controlled trial. Lancet 373(9668):1016–1024. doi:10.1016/S0140-6736(09)60010-6

    Article  PubMed  Google Scholar 

  9. Voormolen MH, Mali WP, Lohle PN, Fransen H, Lampmann LE, van der Graaf Y, Juttmann JR, Jansssens X, Verhaar HJ (2007) Percutaneous vertebroplasty compared with optimal pain medication treatment: short-term clinical outcome of patients with subacute or chronic painful osteoporotic vertebral compression fractures. The VERTOS study. AJNR Am J Neuroradiol 28(3):555–560 (pii: 28/3/555)

    PubMed  CAS  Google Scholar 

  10. Berenson J, Pflugmacher R, Jarzem P, Zonder J, Schechtman K, Tillman JB, Bastian L, Ashraf T, Vrionis F (2011) Balloon kyphoplasty versus non-surgical fracture management for treatment of painful vertebral body compression fractures in patients with cancer: a multicentre, randomised controlled trial. Lancet Oncol 12(3):225–235. doi:10.1016/S1470-2045(11)70008-0

    Article  PubMed  Google Scholar 

  11. Grafe IA, Da Fonseca K, Hillmeier J, Meeder PJ, Libicher M, Noldge G, Bardenheuer H, Pyerin W, Basler L, Weiss C, Taylor RS, Nawroth P, Kasperk C (2005) Reduction of pain and fracture incidence after kyphoplasty: 1-year outcomes of a prospective controlled trial of patients with primary osteoporosis. Osteoporos Int 16(12):2005–2012. doi:10.1007/s00198-005-1982-5

    Article  PubMed  Google Scholar 

  12. Kasperk C, Hillmeier J, Noldge G, Grafe IA, Dafonseca K, Raupp D, Bardenheuer H, Libicher M, Liegibel UM, Sommer U, Hilscher U, Pyerin W, Vetter M, Meinzer HP, Meeder PJ, Taylor RS, Nawroth P (2005) Treatment of painful vertebral fractures by kyphoplasty in patients with primary osteoporosis: a prospective nonrandomized controlled study. J Bone Miner Res 20(4):604–612. doi:10.1359/JBMR.041203

    Article  PubMed  Google Scholar 

  13. Komp M, Ruetten S, Godolias G (2004) Minimally invasive therapy for functionally unstable osteoporotic vertebral fracture by means of kyphoplasty: prospective comparative study of 19 surgically and 17 conservatively treated patients. J Miner Stoffwechs 11(Suppl 1):13–15

    Google Scholar 

  14. Ploeg WT, Veldhuizen AG, The B, Sietsma MS (2006) Percutaneous vertebroplasty as a treatment for osteoporotic vertebral compression fractures: a systematic review. Eur Spine J 15(12):1749–1758. doi:10.1007/s00586-006-0159-z

    Article  PubMed  Google Scholar 

  15. Taylor RS, Taylor RJ, Fritzell P (2006) Balloon kyphoplasty and vertebroplasty for vertebral compression fractures: a comparative systematic review of efficacy and safety. Spine (Phila Pa 1976) 31 (23):2747–2755. doi:10.1097/01.brs.0000244639.71656.7d

  16. Bouza C, Lopez T, Magro A, Navalpotro L, Amate JM (2006) Efficacy and safety of balloon kyphoplasty in the treatment of vertebral compression fractures: a systematic review. Eur Spine J 15(7):1050–1067. doi:10.1007/s00586-005-0048-x

    Article  PubMed  Google Scholar 

  17. Taylor RS, Fritzell P, Taylor RJ (2007) Balloon kyphoplasty in the management of vertebral compression fractures: an updated systematic review and meta-analysis. Eur Spine J 16(8):1085–1100. doi:10.1007/s00586-007-0308-z

    Article  PubMed  Google Scholar 

  18. Hulme PA, Krebs J, Ferguson SJ, Berlemann U (2006) Vertebroplasty and kyphoplasty: a systematic review of 69 clinical studies. Spine (Phila Pa 1976) 31 (17):1983–2001. doi:10.1097/01.brs.0000229254.89952.6b

  19. Hadjipavlou AG, Tzermiadianos MN, Katonis PG, Szpalski M (2005) Percutaneous vertebroplasty and balloon kyphoplasty for the treatment of osteoporotic vertebral compression fractures and osteolytic tumours. J Bone Joint Surg Br 87(12):1595–1604. doi:10.1302/0301-620X.87B12.16074

    Article  PubMed  CAS  Google Scholar 

  20. Rousing R, Andersen MO, Jespersen SM, Thomsen K, Lauritsen J (2009) Percutaneous vertebroplasty compared to conservative treatment in patients with painful acute or subacute osteoporotic vertebral fractures: three-months follow-up in a clinical randomized study. Spine (Phila Pa 1976) 34 (13):1349–1354. doi:10.1097/BRS.0b013e3181a4e628

  21. Kallmes DF, Comstock BA, Heagerty PJ, Turner JA, Wilson DJ, Diamond TH, Edwards R, Gray LA, Stout L, Owen S, Hollingworth W, Ghdoke B, Annesley-Williams DJ, Ralston SH, Jarvik JG (2009) A randomized trial of vertebroplasty for osteoporotic spinal fractures. N Engl J Med 361(6):569–579. doi:10.1056/NEJMoa0900563

    Article  PubMed  CAS  Google Scholar 

  22. Buchbinder R, Osborne RH, Ebeling PR, Wark JD, Mitchell P, Wriedt C, Graves S, Staples MP, Murphy B (2009) A randomized trial of vertebroplasty for painful osteoporotic vertebral fractures. N Engl J Med 361(6):557–568. doi:10.1056/NEJMoa0900429

    Article  PubMed  CAS  Google Scholar 

  23. Bono CM, Heggeness M, Mick C, Resnick D, Watters WC (2010) 3rd North American Spine Society: newly released vertebroplasty randomized controlled trials: a tale of two trials. Spine J 10(3):238–240. doi:10.1016/j.spinee.2009.09.007

    Google Scholar 

  24. Grafe IA, Baier M, Noldge G, Weiss C, Da Fonseca K, Hillmeier J, Libicher M, Rudofsky G, Metzner C, Nawroth P, Meeder PJ, Kasperk C (2008) Calcium-phosphate and polymethylmethacrylate cement in long-term outcome after kyphoplasty of painful osteoporotic vertebral fractures. Spine (Phila Pa 1976) 33(11):1284–1290. doi:10.1097/BRS.0b013e3181714a84

  25. Kasperk C, Grafe IA, Schmitt S, Noldge G, Weiss C, Da Fonseca K, Hillmeier J, Libicher M, Sommer U, Rudofsky G, Meeder PJ, Nawroth P (2010) Three-year outcomes after kyphoplasty in patients with osteoporosis with painful vertebral fractures. J Vasc Interv Radiol 21(5):701–709. doi:10.1016/j.jvir.2010.01.003

    Google Scholar 

  26. Rousing R, Hansen KL, Andersen MO, Jespersen SM, Thomsen K, Lauritsen JM (2010) Twelve-months follow-up in forty-nine patients with acute/semiacute osteoporotic vertebral fractures treated conservatively or with percutaneous vertebroplasty: a clinical randomized study. Spine (Phila Pa 1976) 35 (5):478–482. doi:10.1097/BRS.0b013e3181b71bd1

  27. Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 62(10):1006–1012. doi:10.1016/j.jclinepi.2009.06.005

    Article  PubMed  Google Scholar 

  28. Higgins JPT GS (2009) Cochrane Handbook for systematic reviews of interventions Version 5.0.2. www.cochrane-handbook.org. Accessed May 2010

  29. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med 151(4):W65–94 (pii:0000605-200908180-00136)

    PubMed  Google Scholar 

  30. Borenstein M (2009) Introduction to meta-analysis. Wiley, Chichester

    Book  Google Scholar 

  31. Bucher HC, Guyatt GH, Griffith LE, Walter SD (1997) The results of direct and indirect treatment comparisons in meta-analysis of randomized controlled trials. J Clin Epidemiol 50(6):683–691 (pii: S0895-4356(97)00049-8)

    Article  PubMed  CAS  Google Scholar 

  32. Wells G, Sultan S, Chen L, Khan M, Coyle D (2009) Indirect evidence: indirect treatment comparisons in meta-analysis. Canadian Agency for Drugs and Technologies in Health, Ottawa

    Google Scholar 

  33. Hozo SP, Djulbegovic B, Hozo I (2005) Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol 5(1):13. doi:10.1186/1471-2288-5-13

    Article  PubMed  Google Scholar 

  34. Hrobjartsson A, Gotzsche PC (2001) Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment. N Engl J Med 344(21):1594–1602

    Article  PubMed  CAS  Google Scholar 

  35. Cooper HM, Hedges LV, Valentine JC (2009) The handbook of research synthesis and meta-analysis, 2nd edn. Russell Sage Foundation, New York

    Google Scholar 

  36. Borenstein M, Hedges L, Higgins J, Rothstein H (2005) Comprehensive Meta-analysis Version 2

  37. Wells G, Sultan S, Chen L, Khan M, Coyle D (2009) Indirect treatment comparison [computer program]. Version 1.0. Canadian Agency for Drugs and Technologies in Health, Ottawa

  38. Black DM, Steinbuch M, Palermo L, Dargent-Molina P, Lindsay R, Hoseyni MS, Johnell O (2001) An assessment tool for predicting fracture risk in postmenopausal women. Osteoporos Int 12(7):519–528

    Article  PubMed  CAS  Google Scholar 

  39. Rollinghoff M, Siewe J, Zarghooni K, Sobottke R, Alparslan Y, Eysel P, Delank KS (2009) Effectiveness, security and height restoration on fresh compression fractures–a comparative prospective study of vertebroplasty and kyphoplasty. Minim Invasive Neurosurg 52(5–6):233–237. doi:10.1055/s-0029-1243631

    Article  PubMed  CAS  Google Scholar 

  40. Liu JT, Liao WJ, Tan WC, Lee JK, Liu CH, Chen YH, Lin TB (2010) Balloon kyphoplasty versus vertebroplasty for treatment of osteoporotic vertebral compression fracture: a prospective, comparative, and randomized clinical study. Osteoporos Int 21(2):359–364. doi:10.1007/s00198-009-0952-8

    Article  PubMed  CAS  Google Scholar 

  41. Klazen CA, Lohle PN, de Vries J, Jansen FH, Tielbeek AV, Blonk MC, Venmans A, van Rooij WJ, Schoemaker MC, Juttmann JR, Lo TH, Verhaar HJ, van der Graaf Y, van Everdingen KJ, Muller AF, Elgersma OE, Halkema DR, Fransen H, Janssens X, Buskens E, Mali WP (2010) Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial. Lancet 376:1085–1092. doi:10.1016/S0140-6736(10)60954-3

    Article  PubMed  Google Scholar 

  42. Buchbinder R, Kallmes DF (2010) Vertebroplasty: when randomized placebo-controlled trial results clash with common belief. Spine J 10(3):241–243. doi:10.1016/j.spinee.2010.01.001

    Article  PubMed  Google Scholar 

  43. Han S, Wan S, Ning L, Tong Y, Zhang J, Fan S (2011) Percutaneous vertebroplasty versus balloon kyphoplasty for treatment of osteoporotic vertebral compression fracture: a meta-analysis of randomised and non-randomised controlled trials. Int Orthop. doi:10.1007/s00264-011-1283-x

    Google Scholar 

  44. Holm I, Friis A, Storheim K, Brox JI (2003) Measuring self-reported functional status and pain in patients with chronic low back pain by postal questionnaires: a reliability study. Spine (Phila Pa 1976) 28(8):828–833 (pii:00007632-200304150-00017)

    Google Scholar 

  45. Haywood KL, Garratt AM, Fitzpatrick R (2005) Quality of life in older people: a structured review of generic self-assessed health instruments. Qual Life Res 14(7):1651–1668

    Article  PubMed  CAS  Google Scholar 

  46. Carragee EJ, Cheng I (2010) Minimum acceptable outcomes after lumbar spinal fusion. Spine J 10(4):313–320. doi:10.1016/j.spinee.2010.02.001

    Article  PubMed  Google Scholar 

  47. Gatchel RJ, Mayer TG (2010) Testing minimal clinically important difference: additional comments and scientific reality testing. Spine J 10(4):330–332. doi:10.1016/j.spinee.2010.01.019

    Article  PubMed  Google Scholar 

  48. Yuan HA, Brown CW, Phillips FM (2004) Osteoporotic spinal deformity: a biomechanical rationale for the clinical consequences and treatment of vertebral body compression fractures. J Spinal Disord Tech 17(3):236–242 (pii: 00024720-200406000-00012)

    Article  PubMed  Google Scholar 

  49. Phillips FM, Todd Wetzel F, Lieberman I, Campbell-Hupp M (2002) An in vivo comparison of the potential for extravertebral cement leak after vertebroplasty and kyphoplasty. Spine (Phila Pa 1976) 27 (19):2173–2178. doi:10.1097/01.BRS.0000025689.39941.26 (discussion 2178–2179)

  50. Lee MJ, Dumonski M, Cahill P, Stanley T, Park D, Singh K (2009) Percutaneous treatment of vertebral compression fractures: a meta-analysis of complications. Spine (Phila Pa 1976) 34 (11):1228–1232. doi:10.1097/BRS.0b013e3181a3c742

  51. Schmidt R, Cakir B, Mattes T, Wegener M, Puhl W, Richter M (2005) Cement leakage during vertebroplasty: an underestimated problem? Eur Spine J 14(5):466–473. doi:10.1007/s00586-004-0839-5

    Article  PubMed  CAS  Google Scholar 

  52. Bohner M, Gasser B, Baroud G, Heini P (2003) Theoretical and experimental model to describe the injection of a polymethylmethacrylate cement into a porous structure. Biomaterials 24(16):2721–2730. doi:S0142961203000863

    Article  PubMed  CAS  Google Scholar 

  53. Stoffel M, Wolf I, Ringel F, Stuer C, Urbach H, Meyer B (2007) Treatment of painful osteoporotic compression and burst fractures using kyphoplasty: a prospective observational design. J Neurosurg Spine 6(4):313–319. doi:10.3171/spi.2007.6.4.313

    Article  PubMed  Google Scholar 

  54. Ryu KS, Park CK, Kim MC, Kang JK (2002) Dose-dependent epidural leakage of polymethylmethacrylate after percutaneous vertebroplasty in patients with osteoporotic vertebral compression fractures. J Neurosurg 96(1 Suppl):56–61

    PubMed  Google Scholar 

  55. Cotten A, Dewatre F, Cortet B, Assaker R, Leblond D, Duquesnoy B, Chastanet P, Clarisse J (1996) Percutaneous vertebroplasty for osteolytic metastases and myeloma: effects of the percentage of lesion filling and the leakage of methyl methacrylate at clinical follow-up. Radiology 200(2):525–530

    PubMed  CAS  Google Scholar 

  56. Molloy S, Mathis JM, Belkoff SM (2003) The effect of vertebral body percentage fill on mechanical behavior during percutaneous vertebroplasty. Spine (Phila Pa 1976) 28 (14):1549–1554 (pii: 00007632-200307150-00014)

  57. Liebschner MA, Rosenberg WS, Keaveny TM (2001) Effects of bone cement volume and distribution on vertebral stiffness after vertebroplasty. Spine (Phila Pa 1976) 26(14):1547–1554

    Google Scholar 

  58. Alvarez L, Alcaraz M, Perez-Higueras A, Granizo JJ, de Miguel I, Rossi RE, Quinones D (2006) Percutaneous vertebroplasty: functional improvement in patients with osteoporotic compression fractures. Spine (Phila Pa 1976) 31(10):1113–1118. doi:10.1097/01.brs.0000216487.97965.38

  59. De Negri P, Tirri T, Paternoster G, Modano P (2007) Treatment of painful osteoporotic or traumatic vertebral compression fractures by percutaneous vertebral augmentation procedures: a nonrandomized comparison between vertebroplasty and kyphoplasty. Clin J Pain 23(5):425–430. doi:10.1097/AJP.0b013e31805593be

    Article  PubMed  Google Scholar 

  60. Glassman SD, Bridwell K, Dimar JR, Horton W, Berven S, Schwab F (2005) The impact of positive sagittal balance in adult spinal deformity. Spine (Phila Pa 1976) 30(18):2024–2029 (pii: 00007632-200509150-00005)

  61. Berlemann U, Franz T, Orler R, Heini PF (2004) Kyphoplasty for treatment of osteoporotic vertebral fractures: a prospective non-randomized study. Eur Spine J 13(6):496–501. doi:10.1007/s00586-004-0691-7

    Article  PubMed  Google Scholar 

  62. Lovi A, Teli M, Ortolina A, Costa F, Fornari M, Brayda-Bruno M (2009) Vertebroplasty and kyphoplasty: complementary techniques for the treatment of painful osteoporotic vertebral compression fractures. A prospective non-randomised study on 154 patients. Eur Spine J 18 Suppl 1:95–101. doi:10.1007/s00586-009-0986-9

    Google Scholar 

  63. Dong R, Chen L, Gu Y, Han G, Yang H, Tang T, Xiaoqing C (2009) Improvement in respiratory function after vertebroplasty and kyphoplasty. Int Orthop 33(6):1689–1694. doi:10.1007/s00264-008-0680-2

    Article  PubMed  Google Scholar 

  64. Grohs JG, Matzner M, Trieb K, Krepler P (2005) Minimal invasive stabilization of osteoporotic vertebral fractures: a prospective nonrandomized comparison of vertebroplasty and balloon kyphoplasty. J Spinal Disord Tech 18(3):238–242 (pii: 00024720-200506000-00007)

    PubMed  Google Scholar 

  65. Pflugmacher R, Kandziora F, Schroder R, Schleicher P, Scholz M, Schnake K, Haas N, Khodadadyan-Klostermann C (2005) Vertebroplasty and kyphoplasty in osteoporotic fractures of vertebral bodies—a prospective 1-year follow-up analysis. Rofo 177(12):1670–1676. doi:10.1055/s-2005-858631

    Article  PubMed  CAS  Google Scholar 

  66. Pflugmacher R, Taylor R, Agarwal A, Melcher I, Disch A, Haas NP, Klostermann C (2008) Balloon kyphoplasty in the treatment of metastatic disease of the spine: a 2-year prospective evaluation. Eur Spine J 17(8):1042–1048. doi:10.1007/s00586-008-0701-2

    Article  PubMed  CAS  Google Scholar 

  67. Santiago FR, Abela AP, Alvarez LG, Osuna RM, Garcia MD (2010) Pain and functional outcome after vertebroplasty and kyphoplasty. A comparative study. Eur J Radiol. doi:10.1016/j.ejrad.2010.01.010

    Google Scholar 

  68. Schofer MD, Efe T, Timmesfeld N, Kortmann HR, Quante M (2009) Comparison of kyphoplasty and vertebroplasty in the treatment of fresh vertebral compression fractures. Arch Orthop Trauma Surg 129(10):1391–1399. doi:10.1007/s00402-009-0901-1

    Article  PubMed  Google Scholar 

  69. Bae H, Shen M, Maurer P, Peppelman W, Beutler W, Linovitz R, Westerlund E, Peppers T, Lieberman I, Kim C, Girardi F (2010) Clinical experience using Cortoss for treating vertebral compression fractures with vertebroplasty and kyphoplasty: twenty four-month follow-up. Spine (Phila Pa 1976) 35(20):E1030–1036. doi:10.1097/BRS.0b013e3181dcda75

  70. Venmans A, Klazen CA, Lohle PN, van Rooij WJ, Verhaar HJ, de Vries J, Mali WP (2010) Percutaneous vertebroplasty and pulmonary cement embolism: results from VERTOS II. AJNR Am J Neuroradiol. doi:10.3174/ajnr.A2127

  71. Phillips FM, Ho E, Campbell-Hupp M, McNally T, Todd Wetzel F, Gupta P (2003) Early radiographic and clinical results of balloon kyphoplasty for the treatment of osteoporotic vertebral compression fractures. Spine (Phila Pa 1976) 28(19):2260–2265. doi:10.1097/01.BRS.0000085092.84097.7B (discussion 2265–2267)

  72. Crandall D, Slaughter D, Hankins PJ, Moore C, Jerman J (2004) Acute versus chronic vertebral compression fractures treated with kyphoplasty: early results. Spine J 4(4):418–424. doi:10.1016/j.spinee.2004.01.003

    Article  PubMed  Google Scholar 

  73. Eck JC, Nachtigall D, Humphreys SC, Hodges SD (2008) Comparison of vertebroplasty and balloon kyphoplasty for treatment of vertebral compression fractures: a meta-analysis of the literature. Spine J 8(3):488–497. doi:10.1016/j.spinee.2007.04.004

    Article  PubMed  Google Scholar 

  74. Gill JB, Kuper M, Chin PC, Zhang Y, Schutt R Jr (2007) Comparing pain reduction following kyphoplasty and vertebroplasty for osteoporotic vertebral compression fractures. Pain Physician 10(4):583–590

    PubMed  Google Scholar 

  75. Moher D, Pham B, Jones A, Cook D, Jadad A, Moher M, Tugwell P, Klassen T (1998) Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses? The Lancet 352(9128):609–613

    Article  CAS  Google Scholar 

  76. Diamond TH, Bryant C, Browne L, Clark WA (2006) Clinical outcomes after acute osteoporotic vertebral fractures: a 2-year non-randomised trial comparing percutaneous vertebroplasty with conservative therapy. Med J Aust 184(3):113–117 (pii:dia10749_fm)

    PubMed  Google Scholar 

  77. Movrin I, Vengust R, Komadina R (2010) Adjacent vertebral fractures after percutaneous vertebral augmentation of osteoporotic vertebral compression fracture: a comparison of balloon kyphoplasty and vertebroplasty. Arch Orthop Trauma Surg 130(9):1157–1166. doi:10.1007/s00402-010-1106-3

    Article  PubMed  CAS  Google Scholar 

  78. Kumar K, Nguyen R, Bishop S (2010) A comparative analysis of the results of vertebroplasty and kyphoplasty in osteoporotic vertebral compression fractures. Neurosurgery 67(3 Suppl Operative):on171–188 doi:10.1227/01.NEU.0000380936.00143.11 (discussion ons188)

Download references

Acknowledgments

We thank Mohammed Eleraky, MD (Moffitt Cancer Center, Tampa, FL) for validation and verification of the extracted data.

Conflict of interest

Frank M. Phillips, Jan Van Meirhaeghe, James R. Berenson and Frank D. Vrionis are consultants for Medtronic and have received grants and honoraria. Brent J. Small and Gary Chung were paid from Medtronic to conduct an independent statistical analysis.

Author information

Authors and Affiliations

  1. H. Lee Moffitt Cancer Center and Research Institute, NeuroOncology Program and Department of Neurosurgery and Orthopaedics, University of South Florida College of Medicine, 12902 Magnolia Drive, Tampa, FL, 33647, USA

    Ioannis D. Papanastassiou, Kamran Aghayev & Frank D. Vrionis

  2. Department of Orthopedics, General Oncological Hospital “Agioi Anargyroi”, Athens, Greece

    Ioannis D. Papanastassiou

  3. Dienst Orthopedie en Traumatologie, Algemeen Ziekenhuis Sint-Jan Brugge-Oostende AV, Brugge, Belgium

    Jan Van Meirhaeghe

  4. Medtronic Spinal and Biologics, Kyphon Products Division, Sunnyvale, CA, USA

    Gary Chung

  5. School of Aging Studies, University of South Florida, Tampa, FL, USA

    Brent J. Small

  6. Department of Orthopedics, Rush University Medical Center, Chicago, IL, USA

    Frank M. Phillips & Gunnar B. J. Andersson

  7. Institute for Myeloma and Bone Cancer Research, West Hollywood, CA, USA

    James R. Berenson

Authors
  1. Ioannis D. Papanastassiou
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Frank M. Phillips
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jan Van Meirhaeghe
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. James R. Berenson
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Gunnar B. J. Andersson
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Gary Chung
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Brent J. Small
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Kamran Aghayev
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Frank D. Vrionis
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ioannis D. Papanastassiou.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Papanastassiou, I.D., Phillips, F.M., Van Meirhaeghe, J. et al. Comparing effects of kyphoplasty, vertebroplasty, and non-surgical management in a systematic review of randomized and non-randomized controlled studies. Eur Spine J 21, 1826–1843 (2012). https://doi.org/10.1007/s00586-012-2314-z

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00586-012-2314-z

Keywords

search

Navigation