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Disc degeneration of cervical spine on MRI in patients with lumbar disc herniation: comparison study with asymptomatic volunteers

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Abstract

An association between progression of cervical disc degeneration and that of lumbar disc degeneration has been considered to exist. To date, however, this association has not yet been adequately studied. Age-related changes in the cervical intervertebral discs were evaluated by magnetic resonance imaging (MRI) in patients with lumbar disc herniation, and compared with the MRI findings of healthy volunteers without lower back pain. The purpose of this study was to clarify whether the prevalence of asymptomatic cervical disc degeneration is higher in patients with lumbar disc herniation than in healthy volunteers. The study was conducted on 51 patients who were diagnosed as having lumbar disc herniation and underwent cervical spine MRI. The patients consisted of 34 males and 17 females ranging in age from 21–83 years (mean 46.9 ± 14.5 years) at the time of the study. The control group was composed of 113 healthy volunteers (70 males and 43 females) aged 24–77 years (mean 48.9 ± 14.7 years), without neck pain or low back pain. The percentage of subjects with degenerative changes in the cervical discs was 98.0% in the lumbar disc herniation group and 88.5% in the control group (p = 0.034). The presence of lumbar disc herniation was associated significantly with decrease in signal intensity of intervertebral disc and posterior disc protrusion in the cervical spine. None of the MRI findings was significantly associated with the gender, smoking, sports activities, or BMI. As compared to healthy volunteers, patients with lumbar disc herniation showed a higher prevalence of decrease in signal intensity of intervertebral disc and posterior disc protrusion on MRI of the cervical spine. The result of this study suggests that disc degeneration appears to be a systemic phenomenon.

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References

  1. Aydogan M, Ozturk C, Mirzanli C et al (2007) Treatment approach in tandem (concurrent) cervical and lumbar spinal stenosis. Acta Orthop Belg 73:234–237

    PubMed  Google Scholar 

  2. Battié MC, Videman T, Kaprio J et al (2009) The Twin Spine Study: contributions to a changing view of disc degeneration. Spine J 9:47–59

    Article  PubMed  Google Scholar 

  3. Boden SD, McCowin PR, Davis DO et al (1990) Abnormal magnetic-resonance scans of the cervical spine in asymptomatic subjects. A prospective investigation. J Bone Joint Surg Am 72:1178–1184

    PubMed  CAS  Google Scholar 

  4. Dagi TF, Tarkington MA, Leech JJ (1987) Tandem lumbar and cervical spinal stenosis. Natural history, prognostic indices, and results after surgical decompression. J Neurosurg 66:842–849

    Article  PubMed  CAS  Google Scholar 

  5. Epstein NE, Epstein JA, Carras R et al (1984) Coexisting cervical and lumbar spinal stenosis: diagnosis and management. Neurosurgery 15:489–496

    Article  PubMed  CAS  Google Scholar 

  6. Gore DR, Sepic SB, Gardner GM (1986) Roentgengraphic findings of the cervical spine in asymptomatic people. Spine 11:521–524

    Article  PubMed  CAS  Google Scholar 

  7. Gore DR (2001) Roentgengraphic findings in the cervical spine in asymptomatic persons: a ten-year follow-up. Spine 26:2463–2466

    Article  PubMed  CAS  Google Scholar 

  8. Hirose Y, Chiba K, Karasugi T et al (2008) A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation. Am J Hum Genet 82:1122–1129

    Article  PubMed  CAS  Google Scholar 

  9. Jacobs B, Ghelman B, Marchisello P (1990) Coexistence of cervical and lumbar disc disease. Spine 15:1261–1264

    Article  PubMed  CAS  Google Scholar 

  10. LaBan MM, Green ML (2004) Concurrent (tandem) cervical and lumbar spinal stenosis: a 10-yr review of 54 hospitalized patients. Am J Phys Med Rehabil 83:187–190

    Article  PubMed  Google Scholar 

  11. Lee MJ, Garcia R, Cassinelli EH et al (2008) Tandem stenosis: a cadaveric study in osseous morphology. Spine J 8:1003–1006

    Article  PubMed  Google Scholar 

  12. Lehto IJ, Tertti MO, Komu ME et al (1994) Age-related MRI changes at 0.1 T in cervical discs in asymptomatic subjects. Neuroradiology 36:49–53

    Article  PubMed  CAS  Google Scholar 

  13. MacGregor AJ, Andrew T, Sambrook PN et al (2004) Structural, psychological, and genetic influences on low back and neck pain: a study of adult female twins. Arthritis Rheum 51:160–167

    Article  PubMed  Google Scholar 

  14. Master DL, Eubanks JD, Ahn NU (2009) Prevalence of concurrent lumbar and cervical arthrosis: an anatomic study of cadaveric specimens. Spine 34:E272–E275

    Article  PubMed  Google Scholar 

  15. Matsumoto M, Fujimura Y, Suzuki N et al (1998) MRI of cervical intervertebral discs in asymptomatic subjects. J Bone Joint Surg Br 80:19–24

    Article  PubMed  CAS  Google Scholar 

  16. Mio F, Chiba K, Hirose Y et al (2007) A functional polymorphism in COL11A1, which encodes the alpha 1 chain of type XI collagen, is associated with susceptibility to lumbar disc herniation. Am J Hum Genet 81:1271–1277

    Article  PubMed  CAS  Google Scholar 

  17. Naderi S, Mertol T (2002) Simultaneous cervical and lumbar surgery for combined symptomatic cervical and lumbar spinal stenoses. J Spinal Disord Tech 15:229–232

    PubMed  Google Scholar 

  18. Okada E, Matsumoto M, Ichihara D et al (2009) Aging of the cervical spine in healthy volunteers: a 10-year longitudinal magnetic resonance imaging study. Spine 34(7):706–712

    Article  PubMed  Google Scholar 

  19. Okada E, Matsumoto M, Ichihara D (2009) Does the sagittal alignment of the cervical spine have an impact on disk degeneration? Minimum 10-year follow-up of asymptomatic volunteers. Eur Spine J 18:1644–1651

    Article  PubMed  Google Scholar 

  20. Sambrook PN, MacGregor AJ, Spector TD (1999) Genetic influences on cervical and lumbar disc degeneration: a magnetic resonance imaging study in twins. Arthritis Rheum 42:366–372

    Article  PubMed  CAS  Google Scholar 

  21. Seki S, Kawaguchi Y, Chiba K et al (2005) A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease. Nat Genet 37:607–612

    Article  PubMed  CAS  Google Scholar 

  22. Song YQ, Cheung KM, Ho DW et al (2008) Association of the asporin D14 allele with lumbar-disc degeneration in Asians. Am J Hum Genet 82:744–747

    Article  PubMed  CAS  Google Scholar 

  23. Teng P, Papatheodorou C (1964) Combined cervical and lumbar spondylosis. Arch Neurol 10:298–307

    PubMed  CAS  Google Scholar 

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Acknowledgment

We express our cordial thanks to Daisuke Ichihara M.D. and Kazuhiro Chiba M.D. at Department of Orthopaedic Surgery of Keio University, Suketaka Momoshima M.D. at Department of Diagnostic Radiology of Keio University, Yuji Nishiwaki M.D. at Department of Preventive Medicine and Public Health of Keio University, Ken Ninomiya M.D. and Yukio Horiuchi M.D. at Department of Orthopaedic Surgery of Kawasaki Municipal Hospital, Takeshi Hashimoto M.D. at Department of Orthopaedic Surgery of Keio University Tsukigase Rehabilitation Center, Masahiko Watanabe M.D. at Department of Orthopaedic Surgery of Tokai University, Tomoo Inoue M.D. at Department of Orthopaedic Surgery of Kyorin University, Takeshi Takahata M.D. at Department of Orthopaedic Surgery of Isehara Kyodo Hospital, and Yoshiji Suzuki M.D. of the Omaezaki Municipal Hospital for their cooperation for this study. This study was supported by a grant from the General Insurance Association of Japan.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Keio University, Shinanomachi 35, Shinjuku-ku, Tokyo, 160-8582, Japan

    Eijiro Okada, Morio Matsumoto & Yoshiaki Toyama

  2. Department of Diagnostic Radiology, Keio University, Tokyo, Japan

    Hirokazu Fujiwara

Authors
  1. Eijiro Okada
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  2. Morio Matsumoto
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  3. Hirokazu Fujiwara
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  4. Yoshiaki Toyama
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Correspondence to Morio Matsumoto.

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Okada, E., Matsumoto, M., Fujiwara, H. et al. Disc degeneration of cervical spine on MRI in patients with lumbar disc herniation: comparison study with asymptomatic volunteers. Eur Spine J 20, 585–591 (2011). https://doi.org/10.1007/s00586-010-1644-y

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  • DOI: https://doi.org/10.1007/s00586-010-1644-y

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