Abstract
Intervertebral disc transplantation was developed in a bipedal animal model through the stages of autograft, fresh allograft and fresh frozen allograft. Results showed that the allografts were able to survive through a deep freezing protocol and maintain cell viability after transplantation without significant immunoreaction. Although degeneration of the allograft appeared to be inevitable, it was able to maintain stability and mobility of the functional spinal unit. These findings were similarly reproduced in the human clinical trial with excellent mid-term clinical results at 5 years. The process of evolution and findings were summarized in this review.
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References
Alini M, Roughley PJ, Antoniou J, Stoll T, Aebi M (2002) A biological approach to treating disc degeneration: not for today, but maybe for tomorrow. Eur Spine J Suppl 2:S215–S220
Flynn J, Rudert MJ, Olson E, Baratz M, Hanley E (1990) The effects of freezing or freeze-drying on the biomechanical properties of the canine intervertebral disc. Spine 15(6):567–570
Frick SL, Hanley EN Jr, Meyer RA Jr, Ramp WK, Chapman TM (1994) Lumbar intervertebral disc transfer. A canine study. Spine 19(16):1826–1834
Ho G, Leung VY, Cheung KM, Chan D (2008) Effect of severity of intervertebral disc injury on mesenchymal stem cell-based regeneration. Connect Tissue Res 49(1):15–21
Katsuura A, Hukuda S (1994) Experimental study of intervertebral disc allografting in the dog. Spine 19(21):2426–2432
Lemaire JP, Carrier H, Sariali el H et al (2005) Clinical and radiological outcomes with the Charite artificial disc: a 10-year minimum follow-up. J Spinal Discord Tech 18:353–359
Leung VY, Chan D, Cheung KM (2006) Regeneration of intervertebral disc by mesenchymal stem cells: potentials, limitations, and future direction. Eur Spine J (Suppl 3):S406–S413 [Epub (2006) 15 July Review]
Luk KD, Ruan DK, Chow DH et al (1997) Intervertebral disc autografting in a bipedal animal model. Clin Orthop 337:13–26
Luk KD, Ruan DK, Lu DS et al (2003) Fresh frozen intervertebral disc allografting in a bipedal animal model. Spine 28:864–870
Matsuzaki H, Wakabayashi K, Ishihara K, Ishikawa H, Ohkawa A (1996) Allografting intervertebral discs in dogs: a possible clinical application. Spine 21(2):178–183
Olson EJ, Hanley EN Jr, Rudert MJ, Baratz ME (1991) Vertebral column allografts for the treatment of segmental spine defects. An experimental investigation in dogs. Spine 16(9):1081–1088
Putzier M, Funk JF, Schneider SV et al (2006) Charite total disc replacement—clinical and radiographical results after an average follow-up of 17 years. Eur Spine J 15:183–195
Ruan DK, He Q, Ding Y, Hou LS, Li JY, Luk KDK (2007) Intervertebral disc transplantation in the treatment of degenerative spine disease: a preliminary study. Lancet 369:993–999
Ruan DK, Ding Y, He Q, Luk KDK (2008) Allograft disc transplantation—Preserving segment motion and rebuilding stability of the cervical spine. InSpine 4(2):20–24
Schneiderman G, Flannigan B, Kingston S et al (1987) Magnetic resonance imaging in the diagnosis of disc degeneration: correlation with discography. Spine 12:276–281
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Luk, K.D.K., Ruan, D.K. Intervertebral disc transplantation: a biological approach to motion preservation. Eur Spine J 17 (Suppl 4), 504–510 (2008). https://doi.org/10.1007/s00586-008-0748-0
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DOI: https://doi.org/10.1007/s00586-008-0748-0