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Association between the -1306C/T polymorphism of matrix metalloproteinase-2 gene and lumbar disc disease in Chinese young adults

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Abstract

Matrix metalloproteinase-2 (MMP-2) has been shown to play a pivotal role in the pathophysiology of lumbar disc disease (LDD). Increased expression and activity of MMP-2 has been documented in degenerative discs. The polymorphism -1306C/T in the promoter region of MMP-2 gene was reported to influence gene transcription and expression. The objective of this study was therefore to investigate the possible association of MMP-2 -1306C/T polymorphism with the occurrence and the clinical characteristics of LDD. MMP-2 genotypes were determined by polymerase chain reaction (PCR) and direct DNA sequencing in a case-control study involving 162 younger patients with LDD and 318 age- and sex-matched healthy adults. The results showed that the frequency of MMP-2 -1306CC genotype was significantly higher in LDD patients when compared with controls. Subjects with the CC genotype had nearly threefold increased risk for LDD (odds ratio 3.08; 95% confidence interval 1.84–5.16) compared with subjects carrying at least one variant T allele. Furthermore, this genotype was found to correlate with more severe grades of disc degeneration observed on magnetic resonance imaging scan. These findings suggest that MMP-2 -1306C/T polymorphism may be a genetic risk factor related to LDD susceptibility in the young adult population.

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Authors and Affiliations

  1. Department of Orthopedic Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, China

    D. M. Dong, M. Yao, C. Y. Sun, Y. Q. Jiang & Y. S. Wang

  2. Graduate college of Harbin Medical University, Harbin, China

    B. Liu

Authors
  1. D. M. Dong
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  2. M. Yao
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  3. B. Liu
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  4. C. Y. Sun
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  5. Y. Q. Jiang
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  6. Y. S. Wang
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Correspondence to Y. S. Wang.

Additional information

D. M. Dong and M. Yao contributed equally to this work.

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Dong, D.M., Yao, M., Liu, B. et al. Association between the -1306C/T polymorphism of matrix metalloproteinase-2 gene and lumbar disc disease in Chinese young adults. Eur Spine J 16, 1958–1961 (2007). https://doi.org/10.1007/s00586-007-0454-3

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  • DOI: https://doi.org/10.1007/s00586-007-0454-3

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