Abstract
Since the discovery of the tridecapeptide neurotensin (NTS) in early 1970 by Carraway and Leeman volumes have been written on this peptide related to its structure, synthesis, localization, receptors, and biological actions. The dual functions of NTS as a neurotransmitter/neuromodulator in the brain and as a hormone mediator in peripheral tissues such as the gastrointestinal (GI) tract, adipose tissue, cardiovascular system, lung, liver, pancreas, and spleen have been established. Because of its close association with central dopaminergic and other neurotransmitter systems, NTS is considered an endogenous neuroleptic and its involvement in the pathophysiology of various neuropsychiatric diseases has been suggested. At the periphery, NTS is a major regulator of energy homeostasis; the involvement of this peptide in many diseases related to metabolic disorders such as obesity, diabetes, fatty liver, and cardiovascular disease has been reported. Besides, NTS has been linked to inflammatory bowel disease and several cancers of the gut. Studies on NTS have become an emerging field of research considering its link with many disease conditions. The available reviews focused mostly on NTS involvement in the specific aspects of pathogenesis but not covering the broad spectrums of NTS-related diseases. Through this review, we have attempted a consolidated presentation of studies on the role of NTS in the pathophysiology of various diseases/disorders to provide a one-step resource on this important peptide of health concern. Furthermore, possible therapeutic approaches targeting the NTS system by the use of peptide analogues have been highlighted.
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Mishra, S., Mohanty, B. Neurotensin modulation of inflammation: an update. Comp Clin Pathol 32, 1051–1060 (2023). https://doi.org/10.1007/s00580-023-03530-w
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DOI: https://doi.org/10.1007/s00580-023-03530-w