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Ziziphus jujube protects against cisplatin-induced nephrotoxicity in rats

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Abstract

All components of Ziziphus jujube (ZJ) were used in medicine and food in ancient Iran and China. Cisplatin is one of the most important drugs in the treatment of solid tumors. Taking this drug can result in nephrotoxicity through several mechanisms. The purpose of this study was to evaluate the effects of ZJ on the nephrotoxicity induced by cisplatin in rats. Thirty-five experimental rats were randomly divided into the following five groups (n = 7 per group) for an 8-day study: 1- Group C1 was the control group and received distilled water (1 ml/day); 2- Group C2 received a single dose of intraperitoneal cisplatin (5 mg/kg); 3- Group ZJ received 1500 mg/kg/day Ziziphus Jujube extract orally; 4- Group ZJ1 was given 1500 mg/kg/day of Ziziphus Jujube extract orally with taking a single dose of cisplatin (5 mg/kg) on the first day only; 5- Group ZJ2 received 3000 mg/kg/day of Ziziphus jujube extract orally with taking a single dose of cisplatin (5 mg/kg) on the first day only. Eventually, histopathological parameters, blood urea nitrogen (BUN), malondialdehyde (MDA), alanine transaminase (ALT), and aspartate transaminase (AST) were assessed. The findings showed that cisplatin administration resulted in severe degeneration in all parts of the nephron tubules. Also, the present study showed that MDA levels were significantly lower in both ZJ1 and ZJ2 groups compared with those in group C2 (p < 0.01). Moreover, the cisplatin-induced elevation of serum BUN levels significantly decreased in both ZJ1 and ZJ2 groups in comparison with that in group C2 (p < 0.01). In addition, serum levels of both ALT and AST were significantly higher in group C2 in comparison with those in group C1 (p < 0.05). Extensive tubular necrosis was seen in group C2. In brief, results of this research indicated that ZJ could prevent cisplatin-induced kidney injury in rats.

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Acknowledgments

The authors wish to acknowledge the Vice Chancellery of Research and Technology in Shiraz University of Medical Sciences, Shiraz, I.R. Iran for provision of animal facilities, biochemistry, and histopathology analyses services.

Funding

The authors received provision of enough funds (Grant no 92-01-21-6906) for our project from the Vice Chancellery of Research and Technology in Shiraz University of Medical Sciences, Shiraz, I.R. Iran.

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Authors and Affiliations

  1. Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

    Nader Tanideh

  2. Department of Pharmacology, Shiraz University of Medical Sciences, Shiraz, Iran

    Nader Tanideh & Maryam Mojahed Taghi

  3. School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

    Fariba Zarifi

  4. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Shima Rafiee

  5. Department of Anatomical Sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

    Maryam Khastkhodaei

  6. Laboratory Animals Center, Shiraz University of Medical Sciences, Shiraz, Iran

    Omid Koohi-Hosseinabadi

  7. Legal Medicine Research Center, Legal Medicine Organization of Iran, Tehran, Iran

    Farzane Zarifi

  8. Department of Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

    Zahra Kherad

  9. Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran

    Akram Jamshidzadeh

  10. Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

    Mohammad Ali Farboodniay Jahromi

  11. Student Research Committee, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran

    fatemeh mousavi

  12. Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

    Mahsa Kamali

  13. Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

    Golsa Shekarkhar

  14. Clinical Research Unit, Medical Division, Dasman Diabetes Institute, Dasman, Kuwait

    Mohamed Jahromi

  15. Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, 71947-85947, Iran

    Firoozeh Tarkesh

Authors
  1. Nader Tanideh
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  2. Fariba Zarifi
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  3. Shima Rafiee
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  4. Maryam Khastkhodaei
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  5. Omid Koohi-Hosseinabadi
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  6. Farzane Zarifi
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  7. Zahra Kherad
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  8. Akram Jamshidzadeh
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  9. Mohammad Ali Farboodniay Jahromi
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  10. fatemeh mousavi
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  11. Maryam Mojahed Taghi
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  12. Mahsa Kamali
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  13. Golsa Shekarkhar
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  14. Mohamed Jahromi
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  15. Firoozeh Tarkesh
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Correspondence to Firoozeh Tarkesh.

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Tanideh, N., Zarifi, F., Rafiee, S. et al. Ziziphus jujube protects against cisplatin-induced nephrotoxicity in rats. Comp Clin Pathol 29, 321–326 (2020). https://doi.org/10.1007/s00580-019-03055-1

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  • DOI: https://doi.org/10.1007/s00580-019-03055-1

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