Abstract
The relationship between fructosamine (FRUC) and glucose (GLU) amounts in dog was previously reported. On the other hand, no correlations were reported in transition dairy cow and late-pregnant sheep. Similar controversy also existed concerning the relationship between FRUC, albumin (ALB), and total protein (TP) concentrations. Thirty-three healthy Holstein cows were enrolled in to the study. Blood samples were obtained by jugular venipuncture at 3 and 1 weeks before and 1 and 3 weeks after calving. The concentrations of FRUC, GLU, ALB, TP, β hydroxybutyrate (BHBA), and non-esterified fatty acids (NEFA) were measured with automated biochemical analyzer, using commercial kits. SPSS software, version 20 (SPSS Inc., Chicago, USA) was used for data analysis. The mean ± SE of fructosamine for all cows during the study was 355.6 ± 4.5 μmol/l. There was significant difference in the serum concentration of FRUC post-partum, and throughout of trial, but not at pre-partum period. The maximum concentration of FRUC was at W−1 and decreased thereafter. There were significant positive correlations between FRUC and GLU concentrations at pre-partum, post-partum, and overall time of the study. There were significant negative correlations between FRUC and NEFA concentrations at pre-partum, post-partum, and overall time of the study. There were no correlations between FRUC, TP, ALB, and BHBA amounts at pre-partum, post-partum, and overall time of the study. Linear regression analysis between each sampling amount of GLU and three consecutive FRUC concentrations did not reveal significant correlation between GLU and FRUC. According to present results, fructosamine measurement could be considered as a useful indicator of energy economy in transition period.
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References
Cantley CE, Ford DM, Heath MF (1991) Serum fructosamine in ovine pregnancy toxemia: a possible prognostic index. Vet Rec 128:525–526
Coppo JA (2001) Evolution of fructosaminaemia and glucaemia during the growth of unweaned and early weaned half-bred zebu calves. Vet Res Commun 25:449–459
Coppo JA, Mussart de coppo NB (1997) La glicosilacion de proteinas hematicas como evaluacion retrospective de la glucemia. Aplicaciones en medicina veterinaria. Rev Med Vet 78:292–295
Denis AE, Richard WN, Claudia ER (1999) Comparison of serum fructosamine and blood glycosylated hemoglobin concentration for assessment of glycemic control in cats with diabetes mellitus. J Am Vet Med Assoc 1999(214):1794–1798
Eckersal PD (2008) Proteins, proteomics, and dysproteinemias. In: Kaneko JJ, Harvey JW, Bruss ML (eds) Clinical biochemistry of domestic animals, 6th edn. Academic, San Diego, pp 117–155
Filipović N, Stojević Z, Prvanović N (2010) Serum fructosamine concentrations in relation to metabolic changes during late pregnancy and early lactation in mares. Berl Munch Tierarztl Wochenschr 123:116–173
Filipović N, Stojević Z, Masek T, Mikulec Z, Prvanović N (2011) Relationship between fructosamine with serum protein, albumin and glucose concentrations in dairy ewes. Small Rum Res 96:46–48
Jensen AL, Petersen MB, Houe H (1993) Determination of fructosamine concentration in bovine serum samples. J Vet Med Assoc 40:111–117
Kaneko JJ (2008) Carbohydrate metabolism and its diseases. In: Kaneko JJ, Harvey JW, Bruss ML (eds) Clinical biochemistry of domestic animals, 6th edn. Academic, San Diego, pp 45–80
Kawamoto M, Kaneko JJ, Heusner AA, Feldman EC (1992) Koizumi I) Relation of fructosamine to serum protein, albumin and glucose concentrations in healthy and diabetic dogs. Am J Vet Res 53:851–855
Loste A, Marca MC (1999) Study of the effect of total serum protein and albumin concentrations on canine fructosamine concentration. Can J Vet Res 63:138–141
Loste A, Marca MC, Perez M, Unzueta A (2001) Clinical value of fructosamine measurements in non-healthy dogs. Vet Res Commun 25:109–115
Megahed AA, Hiew MWH, Constable PD (2018) Clinical utility of plasma fructosamine concentration as a hypoglycemic biomarker during early lactation in dairy cattle. J Vet Intern Med 32:846–852
Mostafavi M, Seifi HA, Mohri M, Jamshidi A (2015) Evaluation of fructosamine as a new biomarker for diagnosis of hepatic lipidosis in dairy cows. Anim Prod Sci 55:1005–1010
Pourmohammad R, Mohri M, Seifi HA (2018) Relationship between fructosamine and glucose, total protein, and albumin concentrations of serum in late pregnancy and early lactation of dairy Saanen goat. Iranian J Vet Sci Tech 10:27–32
Radostits OM, Clive CG, Kenneth WH, Constable PD (2007) Veterinary medicine: a text book of the diseases of cattle, horses, sheep, pigs and goats, 10th edn. Saundres Ltd., Philadelphia
Ropstad E (1987) Serum fructosamine levels in dairy cows related to metabolic status in early lactation. Acta Vet Scand 28(3–4):291–298
Sorondo ML, Cirio A (2009) Evaluation of the serum fructosamine test to monitor plasma glucose concentration in the transition dairy cow. J Dairy Res 76:173–178
Sorondo ML, Cirio A (2011) Evaluation of the serum ructosamine test to monitor plasma Glu concentration in the late-pregnant sheep. Anim Prod Sci 51:662–666
Thoresen SI, Bredal WP (1998) An evaluation of serum fructosamine as a marker of the duration of hypoproteinaemic conditions in dogs. Vet Res Commun 22:167–177
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This work was supported by Ferdowsi University of Mashhad, grant number 3/18174.
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The protocol of study was confirmed by animal welfare committee of Ferdowsi University of Mashhad (18174/3) in accordance with institutional and national and/or international guidelines.
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Hasanabadi, M., Mohri, M., Seifi, H.A. et al. Evaluation of the serum fructosamine concentrations in transition period and its relationship with serum proteins and energy characteristics in dairy cows. Comp Clin Pathol 28, 725–730 (2019). https://doi.org/10.1007/s00580-019-02918-x
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DOI: https://doi.org/10.1007/s00580-019-02918-x