Comparative Clinical Pathology

, Volume 28, Issue 4, pp 907–914 | Cite as

Atherosclerosis plaque area reduction: working hypothesis to prevent cardiovascular event

  • Hernán A. Perez
  • Gustavo Flores Allende
  • Ebenezer I. O. Ajayi
  • Daniela J. Porta
  • Néstor H. GarcíaEmail author


Cardiovascular events are the leading cause of death worldwide. In this sense, cardiovascular diseases (CVD) are the main products of atherosclerosis (ATR), whose origin is multifactorial. The measurable identification of the so-called cardiovascular risk factors (CRF) was a great advance for its prevention. Scientific evidences have shown that the reduction of mortality due to cardiovascular disease is an important achievement of the optimal control of CRF. However, a large proportion of patients have cardiovascular events when CRF is controlled. It is therefore imperative to stratify the patient’s risk in order to design the specific and individual treatment strategy. Currently, there are cardiovascular risk classification (CVR) scales that contemplate the combination of the multiple CRF that patients may present, although it is known that most of these algorithms sub- or overestimate the possibility of cardiovascular events. The incorporation of intermediate cardiovascular surrogates to CRF and events, such as the measurement of carotid atherosclerosis, is demonstrating an improvement in the diagnosis and fewer events in the healthy population, with high cardiovascular risk, treated with the incorporation of these to the diagnostic and therapeutic algorithms.


Prevention of cardiovascular event Carotid atherosclerosis Vascular Doppler Hypertension Prevention diet therapy 



The authors acknowledge CONICET, the Argentine Society of Arterial Hypertension, and Blossom DMO for their support in grants.

Funding information

This study was funded by CONICET (grant numbers: Res4541/12 and PIP 2013-2015GI), the Argentine Society of Arterial Hypertension, and Blossom DMO.

Compliance with ethical standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag London Ltd., part of Springer Nature 2018

Authors and Affiliations

  • Hernán A. Perez
    • 1
    • 2
  • Gustavo Flores Allende
    • 3
  • Ebenezer I. O. Ajayi
    • 4
    • 5
  • Daniela J. Porta
    • 6
  • Néstor H. García
    • 6
    Email author
  1. 1.Sanatorio Del Salvador PrivadoCórdobaArgentina
  2. 2.Blossom DMOCórdobaArgentina
  3. 3.Faculty of Medical SciencesNational University of CórdobaCórdobaArgentina
  4. 4.DC&ONID, Biochemistry DepartmentOsun State UniversityOsogboNigeria
  5. 5.IMMF-INIMEC-UNCCONICETCórdobaArgentina
  6. 6.INICSA-UNCCONICETCórdobaArgentina

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