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Endocrine disruption induced by bisphenol A in young and adult female Sprague Dawley rats

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Abstract

Bisphenol A (BPA) is involved chemically in the production of some plastics and as a coating for the inner surface of food containers. The current work aimed to investigate the endocrine-disrupting effect of BPA in young and adult female Sprague Dawley rats. Young and adult female rats were exposed orally to 330 mg/kg body weight of BPA dissolved in ethyl alcohol and suspended in corn oil, day after day for 12 weeks. Control rats dosed orally by the solvent only. The samples were collected every 2 weeks for hormonal assays and histopathological examination. The hormonal assays revealed that there was an increase in estradiol concentration in young female; however, in adult ones, estradiol concentration was decreased after 10 and 12 weeks. Progesterone concentration was decreased in adult ones only at 4 weeks, while testosterone hormone was increased in young female rats. The histopathological finding revealed that there were polycystic follicles in the ovaries of young female, while in adult ones, there were atretic follicles. In conclusion, BPA exposure resulted in endocrine disruption indicated by different responses in hormonal and histopathological changes in both young and adult female rats.

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Authors and Affiliations

  1. Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Assiut University, New Valley, Egypt

    Hayam Hamdy

  2. Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt

    Doha Yahia & Diefy A. Salem

  3. Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt

    Salah Afifi

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  1. Hayam Hamdy
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  2. Doha Yahia
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  3. Salah Afifi
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  4. Diefy A. Salem
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Correspondence to Doha Yahia.

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All procedures involving animals were done in accordance with the ethical standards of Assiut University. All rats were handled according to the standard guidelines for care and use of experimental animals.

This article does not contain any studies with human participants performed by any of the authors

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The authors declare that they have no conflict of interest.

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Hamdy, H., Yahia, D., Afifi, S. et al. Endocrine disruption induced by bisphenol A in young and adult female Sprague Dawley rats. Comp Clin Pathol 27, 967–974 (2018). https://doi.org/10.1007/s00580-018-2689-2

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  • DOI: https://doi.org/10.1007/s00580-018-2689-2

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