Abstract
Dental caries is one of the most common diseases worldwide whose occurrence in children and adolescents has dramatically increased over the past 10 years. It is important to gain better understanding of causes, risk actors, preventions, and associations of tooth decay. This study elucidates a possible mechanism for the predisposition for tooth decay in postnatal ontogenesis in the offspring of hypokinetic pregnant females with regard to the biochemical features of hard dental tissues, calcium-regulating hormones, and histological examination of both hard dental tissues and tooth pulp. Maternal hypokinesia during pregnancy leads to several deficiencies in the progeny, including hypoplasia of odontoblasts and dentinal tubules of teeth, decreases in the collagen levels in dentin, low blood serum levels of parathyroid hormone, and decreases in calcium concentrations in serum and hard dental tissues, all of which determine predisposition to tooth decay. Therefore, maternal hypokinesia during pregnancy is a risk factor for increased dental caries development in the offspring.
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References
Cunha-Cruz J, Scott J, Rothen M (2013) Salivary characteristics and dental caries: evidence from general dental practices. J Am Dent Assoc 144(5):31–40
Gubina-Vakyulyk GI, Sorokina IV, Markovsky VD, Kikhtenko OV, Kupryianova LS, Sydorenko RV (2009) Sposіb kіl'kіsnogo vyznachennja vmіstu antigenu v bіologіchnih rіdinah [The way of quantitative determination of antigen content in biological fluids] UA Patent 46489 [in Ukrainian]
Jakovcova AF, Gubina-Vakyulyk GI (2005) Vlijanie osobennostej vnutriutrobnogo razvitija na adaptacionnye vozmozhnosti posle rozhdenija [Influence of features of intrauterine development on adaptive capacities after birth] Vіd fundamental'nih doslіdzhen' — do progresu v medicinі- From Fundamental Research to the Progress in Medicine:76 [in Russian]
Katzmarzyk PT (2010) Physical activity, sedentary behavior, and health: paradigm paralysis or paradigm shift? Diabetes 59(11):2717–2725
Murthy VE, Smith R, Giles WB et al (2006) Endocrine regulation of the human fetal growth: the role of the mother. Placenta and fetus. Endocrine Rev 27:141–169
Patel J, Landers K, Li H, Mortimer RH et al (2011) Delivery of maternal thyroid hormones to the fetus. Trends Endocrinol Metab 22(5):164–170
Serova LV, Shahmatova EI, Savel'ev SV (1999) Vlijanie gipokinezii na sistemu mat'-plod [Influence of hypokinesia on the mother-fetus system]. Aviokosm Jekolog Med Aviasp Ecol Med 33(2):5–9 [in Russian]
Slin’ko YA, Gubina-Vakyulyk GI (2014) Morfofunkcional'nye osobennosti kostnogo komponenta parodonta u potomstva samok krys, vynoshennogo v usloviyah raznoj dvigatel'noj nagruzki [Morphofunctional features of periodontal bone component of female rats offspring worn-out under different motor load]. Eksperim і klіn med Experim Clin Med 1(62):180–183 [in Russian]
Takaya J, Yamanouchi S, Kaneko K et al (2014) A calcium-deficient diet in rat dams during gestation and nursing affects hepatic 11β-hydroxysteroid dehydrogenase-1 expression in the offspring. PLoS One 9(1):e84125. doi:10.1371/journal.pone.0084125.7
Tashke K (2015) Vvedenie v kolichestvennuyu cito-gistologicheskuyu morfologiyu [Introduction to quantitative cytohistological morphology] / Moscow: IC EHl'-fa. 191 p. [in Russian]
White CP (2009) Calcium metabolism in pregnancy and lactation. Obstet Med 2(1):2–5
Zaidi I, Thayath MN, Singh S et al (2015) Preterm birth: a primary etiological factor for delayed oral growth and development. Int J Clin Pediatr Dent 8(3):215–219
Zorbas YG, Charapakhin KP, Kuznetsov NA et al (1999) Calcium metabolism in bone and teeth of rats during exposure to restriction of motor activity and to swimming exercise. J Physiol Biochem 55(2):73–78
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All applicable international, national, and institutional guidelines for the care and use of animals were followed. All experimental procedures were performed in accordance with the provisions of the European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes (http://www.conventions.coe.int/treaty/en/treaties/word/123.doc).
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Gubina-Vakyulyk, G.I., Gorbach, T.V., Baranova, M.S. et al. Metabolic and histological features of dental tissue in adult rat offspring in maternal hypokinesia. Comp Clin Pathol 26, 1329–1334 (2017). https://doi.org/10.1007/s00580-017-2534-z
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DOI: https://doi.org/10.1007/s00580-017-2534-z