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Generalized lymphoma with a displacing mass in the orbital cavity of a Pacific parrotlet (Forpus coelestis)

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Abstract

In this case report, a 4.5-year-old Pacific parrotlet (Forpus coelestis) with a generalized hematopoietic neoplasia is described. The patient was presented with severe unilateral exophthalmos of the right eye and a poor general health condition. Neither in the general nor the ophthalmologic, nor the subsequent microbiological and mycological examination signs of infection were detected, and molecular tests for Chlamydia psittaci were negative. As the bird’s condition decreased despite intensive care treatment, euthanasia was performed. Postmortem examination revealed a large, space-occupying, bloody mass in the right orbita, displacing the globe. The calvaria seemed to be involved as well as the Paries dorsalis and Paries caudalis of the orbita. Histopathology identified tumor cells in the liver, the spleen, the kidneys, the right eye, and the surrounding orbita, indicating a generalized lymphoma as underlying cause. Immunohistochemical analysis confirmed the swelling to be of B-cell origin. This case report demonstrates that neoplasms should be included in the list of differentials for exophthalmos in psittacines. Moreover, diagnostic options to work off an exophthalmos are described with a special focus on hematopoietic neoplasms in psittacines.

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References

  • Bauck L (1986) Lymphosarcoma/avian leukosis in pet birds-case reports. In: Proceedings of the Annual Conference of the Association of Avian Veterinarians. pp 241–245

  • Campbell T (1984) Lymphoid leukosis in an Amazon parrot. In: Proceedings of the Association of Avian Veterinarians Conference. pp 229–234

  • Coleman C (1995) Lymphoid neoplasia in pet birds: a review. J Avian Med Surg 9:3–7. doi:10.2307/30130664

    Google Scholar 

  • Coleman CW, Oliver R (1994) Lymphosarcoma in a juvenile blue and gold macaw (Ara araruana) and a mature canary (Serinus canarius). J Assoc Avian Vet 8:64–68. doi:10.2307/27671119

    Article  Google Scholar 

  • de Wit M, Schoemaker NJ, Kik MJL, Westerhof I (2003) Hypercalcemia in two Amazon parrots with malignant lymphoma. Avian Dis 47:223–228. doi:10.1637/0005-2086(2003)047[0223:HITAPW]2.0.CO;2

    Article  PubMed  Google Scholar 

  • Desouki MM, Post GR, Cherry D, Lazarchick J (2010) PAX-5: a valuable immunohistochemical marker in the differential diagnosis of lymphoid neoplasms. Clin Med Res 8(2):84–88

  • Doneley B (2010a) Disorders of the eye. In: Avian medicine and surgery in practice: companion and aviary birds. Manson Publishing Ltd, London, pp 133–137

    Chapter  Google Scholar 

  • Doneley B (2010b) Disorders of the lymphatic and haematopoietic systems. In: Avian medicine and surgery in practice: companion and aviary birds. Manson Publishing Ltd, London, pp 200–202

    Chapter  Google Scholar 

  • Doneley B (2010c) Neurological assessment. In: Avian medicine  and surgery in practice: companion and aviary birds. Manson Publishing Ltd, London, pp 52–54

  • Dukes TW, Pettit JR (1983) Avian ocular neoplasia - a description of spontaneously occurring cases. Can J Comp Med 47(1):33–36.

  • Effron M, Griner L, Benirschke K (1977) Nature and rate of neoplasia found in captive wild mammals, birds, and reptiles at necropsy. J Natl Cancer Inst 59:185–198

    Article  CAS  PubMed  Google Scholar 

  • Filippich LJ (2004) Tumor control in birds. Semin Avian Exot Pet Med 13:25–43. doi:10.1053/S1055-937X(03)00055-0

    Article  Google Scholar 

  • Freundt CM, Schaeffer L (2014) Retrobulbar rhabdomyosarcoma in a neotropical peregrine falcon (Falco peregrinus cassini). Vet Ophthalmol 17:73–75. doi:10.1111/vop.12072

    Article  Google Scholar 

  • Gregory CR, Latimer KS, Mahaffey EA, Doker T (1996) Lymphoma and leukemic blood picture in an emu (Dromaius novaehollandiae). Vet Clin Pathol 25(4):136–139

  • Griner L (1983) Pathology of zoo animals. Birds: order Psittaciformes. Zoological Society of San Diego, San Diego, California

    Google Scholar 

  • Harrison GJ, Lightfoot TL (2006) Clinical Avian Medicine, vol. 2. Spix Publishing, Inc., Palm Beach, Florida

    Google Scholar 

  • Hubbard GB, Schmidt RE, Fletcher KC (1983) Neoplasia in zoo animals. J Zoo Anim Med 14:33–40. doi:10.2307/20094627

    Article  Google Scholar 

  • Kaltenböck B, Schmeer N, Schneider R (1997) Evidence for numerous omp1 alleles of porcine Chlamydia trachomatis and novel chlamydial species obtained by PCR. J Clin Microbiol 35:1835–1841

    PubMed  PubMed Central  Google Scholar 

  • Kellner SJ (2008) Eye and eylid injuries. In: Samour J (ed) Avian Medicine, 2nd edn. Elsevier, Philadelphia, pp 204–207

    Google Scholar 

  • Kern TJ (1997) Disorders of the special senses. In: Altmann RB, Clubb SL, Dorrestein GM, Quesenberry K (eds) Avian Medicine and Surgery. WB Saunders, Philadephia, pp 563–589

    Google Scholar 

  • Kollias GV, Homer B, Thompson PJ (1992) Cutaneous pseudolymphoma in a juvenile blow and gold macaw (Ara ararauna). J Zoo Wildl Med 23:235–240

    Google Scholar 

  • Kutkiene L, Prakas P, Sruoga A, Butkauskas D (2009) Sarcocystis in the birds family Corvidae with description of Sarcocystis cornixi sp. nov. from the hooded crow (Corvus cornix). Parasitol Res 104:329–336. doi:10.1007/s00436-008-1196-9

    Article  PubMed  Google Scholar 

  • Latimer KS (1994) Oncology. In: Ritchie BW, Harrison GJ, Harrison LR (eds) Avian medicine: principles and application. Wingers, Lake Worth, Florida, pp 640–672

    Google Scholar 

  • Newell S (1991) Diagnosis and treatment of lymphocytic leukemia and malignant lymphoma in a Pekin duck. J Assoc Avian Vet 5:83–86

    Article  Google Scholar 

  • Paul-Murphy J, Lowenstine L, Turrel J (1985) Malignant lymphoreticular neoplasm in an African gray parrot. J Am Vet Med Assoc 187:1216–1217

    CAS  PubMed  Google Scholar 

  • Petrak M, Gilmore CE (1982) Neoplasms. In: Petrak ML (ed) Diseases of cage and aviary birds, 2nd edn. Lea & Felbinger, Philadelphia, pp 606–637

    Google Scholar 

  • Ramos-Vara J, Smith E, Watson G (1997) Lymphosarcoma with plasmacytoid differentiation in a scarlet macaw (Ara macao). Avian Dis 41:499–504

    Article  CAS  PubMed  Google Scholar 

  • Reece RL (1992) Some observations on naturally occurring neoplasms in birds in the state of Victoria, Australia. Avian Pathol 21:3–32. doi:10.1080/03079459608419153

    Article  CAS  PubMed  Google Scholar 

  • Ritchie BW, Harrison GJ, Harrison LR (eds) (1994) Examination of the patient. In: Avian medicine: princicples and application. Wingers, Lake Worth, Florida, pp 156–175

  • Rivera S, McClearen JR, Reavill DR (2009) Treatment of nonepitheliotropic cutaneous B-cell lymphoma in an umbrella cockatoo (Cacatua alba). J Avian Med Surg 23:294–302. doi:10.1647/2008-032R.1

    Article  PubMed  Google Scholar 

  • Rodriguez-Tovar LE, Casas-Martínez A, Ramírez-Romero R, Nevárez-Garza AM, Zarate-Ramos JJ (2008) First report of Oxyspirura sp. from a captive fulvous owl (Strix fulvescens) in Mexico. J Parasitol 94:1430–1431. doi:10.1645/GE-1599.1

  • Schmidt RE, Reavill DR, Phalen DN (eds) (2003) Lymphatic and hematopoietic system. In: Pathology of pet and aviary birds. Blackwell Publishing, Ames, Iowa, pp 131–148

  • Shimakura S, Sawa H, Yamashita T, Hirai K (1981) An outbreak of ocular disease caused by staphylococcal infection in Amazon parrot (Amazona aestiva) imported into Japan. Jpn J Vet Sci 43:273–275

    Article  CAS  Google Scholar 

  • Siegmann O, Neumann U (eds) (2012) Geflügelsektion. In: Kompendium der Geflügelkrankheiten, 7th edn. Schlütersche Verlagsgesellschaft, Hannover, Germany, pp 92–94

  • Simova-Curd S, Nitzl D, Mayer J, Hatt J-M (2006) Clinical approach to renal neoplasia in budgerigars (Melopsittacus undulatus). J Small Anim Pract 47:504–511. doi:10.1111/j.1748-5827.2006.00146.x

    Article  CAS  PubMed  Google Scholar 

  • Vail, D, MacEwan E (2013) Canine lymphoma and lymphoid leukemias. In: Withrow and MacEwen’s Small Animal Clinical Oncology, 5th edn, Saunders, Philadelphia, pp 608–637

  • Valli, VE (ed) (2002) Histological classification of hematopoietic tumors of domestic animals.  WHO international classification of tumors of domestic animals, vol 8, American Registry of Pathology

  • Valli VE, Kass PH, San Myint M, Scott F (2013) Canine lymphomas: association of classification type, disease stage, tumor subtype, mitotic rate, and treatment with survival. Vet Pathol 50:738–748. doi:10.1177/0300985813478210

    Article  CAS  PubMed  Google Scholar 

  • Watson VE, Murdock JH, Cazzini P, Schnellbacher R, Divers SJ, Sakamoto K (2013) Retrobulbar adenocarcinoma in an Amazon parrot (Amazona autumnalis). J Vet diagnostic Investig 25:273–276. doi:10.1177/1040638712474817

    Article  Google Scholar 

  • Williams D (1994) Ophthalmology. In: Ritchie BW, Harrison GJ, Harrison LR (eds) Avian medicine: principles and application. Wingers, Lake Worth, Florida, pp 673–694

    Google Scholar 

  • Willis AM, Wilkie DA (2012) Avian ophthalmology, part 2 : review of ophthalmic diseases. J Avian Med Surg 13:245–251

  • Willis AM, Wilkie DA (1999) Avian ophthalmology part 1: anatomy, examination, and diagnostic techniques. J Avian Med Surg 13:160–166

    Google Scholar 

  • Woodhouse S, Rose M, Desjardins DR, Agnew DW (2015) Diagnosis of retrobulbar round cell neoplasia in a macaroni penguin (Eudyptes chrysolophus) through use of computed tomography. J Avian Med Surg 29:40–45. doi:10.1647/2014-014

    Article  PubMed  Google Scholar 

  • Zachary JF, McGavin MD (2012) Pathologic basis of veterinary disease. 5th edn, Elsevier Health Sciences, St. Louis, Missouri

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Author notes

  1. Sylvia Parmentier and Dominik Fischer contributed equally to this work.

Authors and Affiliations

  1. Clinic for Birds, Reptiles, Amphibians and Fish, Justus Liebig University Giessen, Frankfurter Strasse 91, 35392, Giessen, Germany

    Sylvia Parmentier, Dominik Fischer, Elisa Wüst & Michael Lierz

  2. Department of Veterinary Medicine at the Freie Universität Berlin / Institute of Veterinary Pathology, Robert-von-Ostertag-Strasse 15, 14163 Berlin, Germany

    Olivia Kershaw

Authors
  1. Sylvia Parmentier
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  2. Dominik Fischer
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  3. Elisa Wüst
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  4. Olivia Kershaw
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  5. Michael Lierz
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Correspondence to Dominik Fischer.

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All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Parmentier, S., Fischer, D., Wüst, E. et al. Generalized lymphoma with a displacing mass in the orbital cavity of a Pacific parrotlet (Forpus coelestis). Comp Clin Pathol 26, 1389–1394 (2017). https://doi.org/10.1007/s00580-017-2527-y

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