Abstract
Osteosarcoma, as a progressive tumor, accounts for approximately 80% of malignant bone tumors in dogs. Since it is a highly metastatic tumor, it develops pulmonary metastasis in the majority of cases. The considerable site preference of the tumor in dogs and the possibility of hypertrophic osteopathy in a number of cases must be considered. Clinical examination of a 12-year female German shepherd dog with lameness, weakness, and cachexia revealed an abnormal thickening in the left forelimb and a severe swelling in the left proximal humerus. Radiographic examinations showed severe swelling in the arm’s soft tissue, proximal humerus osteolysis, and irregular and palisade periosteal reaction in most bones of thoracic and pelvic limbs as well as soft-tissue masses in the thoracic cavity. In postmortem examination, a semi-hard destructive mass extended from the central cavity of humerus to the surrounding soft tissue, pulmonary and splenic metastases were observed. According to microscopic features, the tumoric bone lesion was diagnosed as fibroblastic osteosarcoma. Hypertrophic osteopathy (Marie’s disease) was also diagnosed due to gross characteristics of the forearm and palm along with radiographic findings of the forearm and tibia. This is the first report of simultaneous occurrence of fibroblastic osteosarcoma and Marie’s disease in Iranian dogs.
References
Baniadam A, Ahmadian F, Mohammadian B, Mosallanejad B, Ghadiri AR (2009) Surgical treatment of osteosarcoma in the ribs of a dog: a case report. Int J Vet Res 4(1):29–32
Barger A, Graca R, Bailey K, Messick J, de Loriemer L-P, Fan T, Hoffmann W (2005) Use of alkaline phosphatase staining to differentiate canine osteosarcoma from other vimentin-positive tumors. Vet Pathol 42:161–165. doi:10.1354/vp.42-2-161
Brodey RS, Riser WH (1969) Canine osteosarcoma: a clinicopathologic study of 194 cases. Clin Orthop Relat Res 62:54–64
Bundza A, Grieg AS, Speckmann GW (1979) Osteolytic osteosarcoma in a German shepherd bitch. Can Vet J 20(2):53–57
Bush M, James EJ, Montali RJ, Sauer RM, Heller RH, Gray CW (1974) Hypertrophic pulmonary osteoarthropathy in a lioness (Panthera leo). J Am Vet Radiol Soc 15:84–90
Cavalcanti JN, Amstalden EMI, Guerra JL, Magna LC (2004) Osteosarcoma in dogs: clinical-morphological study and prognostic correlation. Braz J Vet Res Anim Sci 41(5):299–305
Cetinkaya MA, Yardimci B, Yardimci C (2011) Hypertrophic osteopathy in a dog associated with intra-thoracic lesions: a case report and a review. Vet Med 56(12):595–601
Fattahian HR, Sharifi D, Bakhtiari J, Dezfulian O, Veshkini A, Gransar A (2002) Clinical report of distal metaphyseal osteosarcoma of femoral bone in two Doberman dogs. J Fac Vet Med Univ Tehran 57(4):73–76
Fattahian H, Hesaraki S, Fazeli O, Kabir F, Rohani Hajiagha SR (2008) Immunohistochemical study of giant cell osteosarcoma in a dog. IJVS 3(3):99–106
Ginel PJ, Novales M, Molleda JM, Perez J, Mozos E (1996) Mandibular fibroblastic osteosarcoma in a three-month-old dog. Vet Rec 139:120–121
Hammer AS, Weeren FR, Weisbrode SE, Padget SL (1995) Prognostic factors in dogs with osteosarcoma of the flat or irregular bones. J Am Anim Hosp Assoc 31(4):321–326
Loukopoulos P, Robinson WF (2007) Clinicopathological relevance of tumour grading in canine osteosarcoma. J Comp Pathol 165:65–73. doi:10.1016/j.jcpa.2006.11.005
Oryan A, Sadoughifa R, Shirian S, Farjani Kish G, Daneshbod Y (2015) Giant cell-rich osteosarcoma of tibia in a dog: a pathological and immunohistochemical study. Comp Clin Pathol 24:177–179. doi:10.1007/s00580-014-1892-z
Rahal SC, Mamprim MJ, Sequeira JL, Franco APR (2003) Hypertrophic osteopathy associated with pulmonary metastasis of osteosarcoma in a dog. Ars Vet 1:35–39 In Brazilian with English abstract
Rodrigues BA, Faraco C, Oliveira R, Cheuiche S, Teixeira FS, Kirst C, Faraon A, Sousa EM (2009) Pelvic osteosarcoma resection in a bitch: case report. Arq Bras Med Vet Zootec 61(1):35–41
Slayter MV, Boosinger TR, Pool RR, Dammrich K, Mistorp W, Larsen S (1994) Histological classification of bone and joint tumors of domestic animals, WHO 2nd series, vol Vol. 1. Armed Forces Institute of Pathology, American Registry of Pathology, Washington DC
Spodnick GJ, Berg J, Rand WM, Schelling SH, Couto G, Harvey HJ, Henderson RA, McEwen G, Mauldin N, McCaw DL, Moore AS, Morrison W, Norris AM, Obradovich J, Okeefe DA, Page R, Ruslander D, Klausner J, Straw R, Thompson JP, Withrow SJ (1992) Prognosis for dogs with appendicular osteosarcoma treated by amputation alone: 162 cases (1978-1988). J Am Vet Med Assoc 200(7):995–999
Thompson K (2007) Bones and joints. In: Maxie G (ed) Jubb, Kennedy & Palmers’ pathology of domestic animals, 5th edn. Elsevier, Edinburgh, pp 107–108 114–116
Thompson KG, Pool RR (2002) Tumors of bones. In: Meuton DJ (ed) Tumors in domestic animals, 4th edn. Iowa state press, Iowa, pp 266, 281
Trost ME, Kommers GD, Brown CC, Barros CSL, Irigoyen FL, Fighera RA, Inkelmann MA, Dasilva TM (2012) Primary bone neoplams in dogs: 90 cases. Pesqui Vet Bras 32(12):1329–1335
Withrow SJ, Powers BE, Straw RC, Wilkins RM (1991) Comparative aspects of osteosarcoma. Dog versus man. Clin Orthop Relat Res 270:159–168
Acknowledgements
Technical assistance of Ms. F. Behdarvand and Mr. H. Behdarvand to prepare microscopic sections and detailed revision of the manuscript by Dr. M. Validi are deserved to be acknowledged.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Ethical approval
During all stages of our research, all applicable international, national, and/or institutional guidelines for the care and use of animals were followed. There has been no significant financial support for this research work.
Conflict of interests
The authors declare that they have no conflict of interest.
Rights and permissions
About this article
Cite this article
Esmaeilzadeh, S., Rahnemoon, A.A., Mosallanejad, B. et al. Simultaneous occurrence of fibroblastic osteosarcoma and hypertrophic osteopathy (Marie’s disease) in a German shepherd dog. Comp Clin Pathol 26, 1233–1236 (2017). https://doi.org/10.1007/s00580-017-2520-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00580-017-2520-5