The effect of chronic noise stress on serum levels of cortisol, gonadotropins, and sexual hormones at implantation time of mice

Abstract

Noise pollution is disturbing noise that may harm the balance of human or animal life. This study was designed to examine the effects of noise stress on serum levels of follicular stimulating hormone (FSH), luteinizing hormone (LH), corticosterone, estrogen, and progesterone of mature female NMARI mice at implantation time. In this experimental study, 30 mature female mice were divided into three equal groups. Pseudopregnancy was induced in all groups. The experimental groups 1 and 2 were exposed to noise. After 30 days that noise stress was induced, pseudopregnancy was performed. The experimental groups were exposed to noise stress for 4.5 days. At the end of the last exposure, the animals were anesthetized; afterwards, blood samples were collected. The ELISA technique for determination of the levels of cortisol, estrogen, progesterone, FSH, and LH in serum specimens was used. The results showed reduction of FSH and LH and increasing of corticosterone, in the mature female mice exposed to the noise stress, in the experimental groups compared to the control group. Also, the estrogen level in the experimental groups significantly increased as compared to that in the control group. Regarding the level of progesterone, there was a significant difference between the control and experimental group 2, while there was no significant difference between the control and experimental group 1. Noise stress can reduce gonadotropins and sex hormones at implantation time.

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Acknowledgements

The results describe in this paper is part of the M.Sc. thesis; the present work was financially supported by grant number 9493 from deputy of research and technology, Kashan University of Medical Sciences.

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Correspondence to Tahere Mazoochi.

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The experiments were approved by the ethical committee of Kashan University of Medical Sciences and performed in accordance with the directive 2010/63/EU on the protection of animals used for scientific purposes.

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This paper is our original unpublished work and it has not been submitted to any other journals for reviews.

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The authors declare that they have no competing interests.

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Shafiei, A., Ehteram, H., Akbari, H. et al. The effect of chronic noise stress on serum levels of cortisol, gonadotropins, and sexual hormones at implantation time of mice. Comp Clin Pathol 26, 779–784 (2017). https://doi.org/10.1007/s00580-017-2446-y

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Keywords

  • Noise stress
  • Gonadotropin hormones
  • Sex hormones
  • Implantation
  • Pseudopregnancy