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Silymarin and methionine application on treatment of liver chronic diseases by aflatoxicosis in rabbit (Oryctolagus cuniculi)—case report

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Abstract

This case report describes the treatment of chronic liver disease in rabbit (Oryctolagus cuniculi) caused by consumption of feed containing mycotoxin and later treated with silymarin. A young female rabbit was referred to veterinary care with a history of apathy, appetite loss, and difficulty breathing without a clear medical history. The physical examination revealed an increase in the abdominal volume, an observation confirmed by radiographic analysis showing the presence of ascites. Through the serum biochemistry evaluation, it was an evidenced liver disease. After 1 month of treatment, the animal did not present any clinical changes, as well as, it had its hematological and biochemical parameters normalized. The continued use of silymarin along with methionine was effective in the treatment of toxic liver disease by aflatoxin B1 intake in a rabbit, having reversed toxic effects and serum biochemical patterns resettled.

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Authors and Affiliations

  1. DVM, Campus of Xanxerê, Universidade do Oeste de Santa Catarina, Xanxerê, Santa Catarina, Brazil

    Guilherme Augusto Marietto-Gonçalves & Alexandre Alberto Tonin

  2. Undergraduate in Veterinary Medicine, Campus of Xanxerê, Universidade do Oeste de Santa Catarina, Joaçaba, Santa Catarina, Brazil

    Marianna Bergmann Brito

  3. Veterinarian, Me., Veterinary Clinical Laboratory Services, Campus of Xanxerê, Universidade do Oeste de Santa Catarina, Joaçaba, Santa Catarina, Brazil

    Eliana Lucia Fiorentin

Authors
  1. Guilherme Augusto Marietto-Gonçalves
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  2. Marianna Bergmann Brito
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  3. Eliana Lucia Fiorentin
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  4. Alexandre Alberto Tonin
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Corresponding author

Correspondence to Guilherme Augusto Marietto-Gonçalves.

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This is a case report, thus, without any experimental model or designs. Therefore, this article does not contain any studies with animals performed by any of the authors.

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The authors declare that they have no conflict of interest.

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Marietto-Gonçalves, G.A., Brito, M.B., Fiorentin, E.L. et al. Silymarin and methionine application on treatment of liver chronic diseases by aflatoxicosis in rabbit (Oryctolagus cuniculi)—case report. Comp Clin Pathol 26, 719–722 (2017). https://doi.org/10.1007/s00580-017-2401-y

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  • DOI: https://doi.org/10.1007/s00580-017-2401-y

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