Comparative Clinical Pathology

, Volume 25, Issue 5, pp 1007–1011 | Cite as

D-dimer concentrations in dogs with kidney disease with or without protein-losing nephropathy

  • Efstathios Roumpeas
  • Polychronis Kostoulas
  • Zoe Polizopoulou
  • Christos K. Koutinas
  • Mathios E. MylonakisEmail author
Original Article


Limited information is currently available regarding the range of D-dimer concentrations in dogs with kidney disease (KD). The objective of the present cross-sectional study was to investigate the concentration of D-dimers in dogs with KD irrelevant of the underlying cause or the time course of the KD and the potential association of D-dimers elevation with serum creatinine concentration, concurrent protein-losing nephropathy (PLN) or the age of the animals. D-dimers were measured by a semi-quantitative plasma latex agglutination assay in 31 healthy dogs (group A) and in 30 dogs with KD (group B), without evidence of concurrent extra-renal disease that may precipitate hypercoagulation. Significantly higher median D-dimer concentrations (p = 0.0133) and a higher prevalence of increased D-dimers (≥250 μg/L) (p = 0.011) were documented in dogs with KD as compared to healthy dogs, and the increased D-dimers were not associated with the serum creatinine concentration, the coexistent PLN or the age of the dogs. In conclusion, the detection of increased D-dimers in the context of impaired kidney function should be cautiously interpreted in the dog and should not be invariably assumed to imply the presence of a state of hypercoagulability.


D-dimers Dog Kidney disease Thrombosis 


Compliance with ethical standards


This research was financially supported by the Companion Animal Clinic, School of Veterinary Medicine, Aristotle University of Thessaloniki. No funding sources had any involvement in study design, in collection, analysis and interpretation of data, in writing report(s) and in the decision to submit the article for publication.

Ethical approval

All applicable international, national and/or institutional guidelines for the care and use of animals were followed.

Conflict of interest

The authors declare that they have no competing interests.


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Copyright information

© Springer-Verlag London 2016

Authors and Affiliations

  • Efstathios Roumpeas
    • 1
  • Polychronis Kostoulas
    • 2
  • Zoe Polizopoulou
    • 3
  • Christos K. Koutinas
    • 1
  • Mathios E. Mylonakis
    • 1
    Email author
  1. 1.Companion Animal Clinic, School of Veterinary MedicineAristotle University of ThessalonikiThessalonikiGreece
  2. 2.Laboratory of Epidemiology, Biostatistics and Animal Health Economics, School of Veterinary SciencesUniversity of ThessalyKarditsaGreece
  3. 3.Diagnostic Laboratory, School of Veterinary MedicineAristotle University of ThessalonikiThessalonikiGreece

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