Herbal remedies against gastric cancer in experimental rats
- 159 Downloads
Gastric cancer is the fourth most prevalent cancer worldwide, which claims more than 700,000 lives every year. However, the current chemical and surgical management of this mortal cancer remains far from successful. A recent safe approach to preventing or treating tumorigenesis has been the re-introduction of traditional herbal medicine, taking advantage of efficient, yet natural healthy products. In this review, we have focused on a number of such popular agents, mostly introduced by the Traditional Chinese medicine (TCM), which have exhibited highly significant preventive/therapeutic effects against various gastric pathologies, ranging from gastritis to premalignant lesions and confirmed malignancies, in experimental rats. The underlying mechanisms of action seem to concentrate on shifting the balance between in vivo oxidant and anti-oxidant activities. In addition, the existing reports on the potential toxicity of these compounds, as well as their interactions with chemical drugs, have been presented. However, far more details are required to recommend herbal medicine as an effective and reliable plan of action in gastric cancer management.
KeywordsGastric Rat model Herbal Traditional Toxicity Drug interaction
This study was supported by a technical assistance grant (IRN‑072), which was co‑funded by the Islamic Development Bank, Saudi Arabia and Pasteur Institute of Iran.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
- Chen H-H, Chen Y-T, Huang Y-W, Tsai H-J, Kuo C-C (2012) 4-Ketopinoresinol, a novel naturally occurring ARE activator, induces the Nrf2/HO-1 axis and protects against oxidative stress-induced cell injury via activation of PI3K/AKT signaling. Free Radic Biol Med 52:1054–1066CrossRefPubMedGoogle Scholar
- Draudin-Krylenko V, Bukin I, Levchuk A, Davéĭ F (1991) Potential cancer-protective effect of beta-carotene in experimental stomach carcinogenesis. Vopr Med Khim 38:36–39Google Scholar
- Huang D-W, Kuo Y-H, Lin F-Y, Lin Y-L, Chiang W (2009b) Effect of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) Testa and its phenolic components on Cu2+-treated low-density lipoprotein (LDL) oxidation and lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 macrophages. J Agric Food Chem 57:2259–2266CrossRefPubMedGoogle Scholar
- Hyun TK, Kim J-S (2009) The pharmacology and clinical properties of Kalopanax pictus. J Med Plants Res 3:613–620Google Scholar
- Kato I, Tominaga S, Matsuura A, Yoshii Y, Shirai M, Kobayashi S (1990) A comparative case control study of colorectal cancer and adenoma. Cancer Sci 81:1101–1108Google Scholar
- Liu N, Sun B, Wu P, Wei X (2015a) Chemopreventive effects of Azadirachta indica on cancer marker indices and ultrastructural changes during 1, 2-dimethylhydrazine-induced colon carcinogenesis in rats. Cell biochemistry and biophysics:1–6Google Scholar
- Manikandan P, Vidjaya LP, Prathiba D, Nagini S (2008) Combinatorial chemopreventive effect of Azadirachta indica and Ocimum sanctum on oxidant-antioxidant status, cell proliferation, apoptosis and angiogenesis in a rat forestomach carcinogenesis model. Singap Med J 49:814–822Google Scholar
- Mohammad Alizadeh A et al (2015) Chemoprotection of MNNG-initiated gastric cancer in rats using Iranian propolis. Arch Iranian Med(AIM) 18:18–23Google Scholar
- Murugan RS, Mohan KVPC, Uchida K, Hara Y, Prathiba D, Nagini S (2007) Modulatory effects of black tea polyphenols on oxidant–antioxidant profile and expression of proliferation, apoptosis, and angiogenesis-associated proteins in the rat forestomach carcinogenesis model. J Gastroenterol 42:352–361CrossRefPubMedGoogle Scholar
- Yang W, Li W, Chen J, Chen X (2007) [Preventive effects of 4 Se-enriched plants on rat stomach cancer induced by MNNG--1. Inhibitary effects of different selenium resources on rat aneuploid cell incidence in mucosal epithelium of gastric antrum]. Wei sheng yan jiu. J Hygiene Res 36:612–614Google Scholar