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Clinical evaluation of the effects of supplementation with curcuminoids on serum fetuin-B concentrations in obese subjects

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Abstract

Fetuin-B is an emerging negative acute phase protein, and its expression is inversely associated with inflammation. The present study aimed to assess the impact of supplementation with curcuminoids, as naturally occurring polyphenols with anti-inflammatory properties, on circulating concentrations of fetuin-B. In this randomized double-blind trial, 30 obese dyslipidemic subjects received curcuminoids (1 g/day) and matching placebo. The trial had a 2 × 2 crossover design, in which treatment duration with either of the allocations was 4 weeks, intermitted by a 2-week washout period. Serum fetuin-B concentrations were determined at the end of each treatment period. The groups were comparable regarding baseline demographic characteristics and serum fetuin-B concentrations. Supplementation with curcuminoids did not significantly change serum fetuin-B levels compared with placebo (p > 0.05). Serum fetuin-B levels were not found to be correlated with lipid profile parameters nor C-reactive protein in either curcuminoids or placebo groups (p > 0.05). Four-week supplementation with curcuminoids in obese subjects has no significant effect on circulating fetuin-B concentrations.

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Acknowledgments

This study was financially supported by a grant from the Mashhad University of Medical Sciences Research Council (Mashhad, Iran). The support granted by the Iran National Science Foundation (Tehran, Iran) is also gratefully acknowledged.

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Authors and Affiliations

  1. Student Research Committee, Department of Modern Sciences & Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Maryam Saberi Karimian

  2. Cardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Majid Ghayour-Mobarhan

  3. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran

    Amirhossein Sahebkar

Authors
  1. Maryam Saberi Karimian
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  2. Majid Ghayour-Mobarhan
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  3. Amirhossein Sahebkar
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Correspondence to Amirhossein Sahebkar.

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The study protocol was approved by the Ethics Committee at the Mashhad University of Medical Sciences, Mashhad, Iran (code: 930592).

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Saberi Karimian, M., Ghayour-Mobarhan, M. & Sahebkar, A. Clinical evaluation of the effects of supplementation with curcuminoids on serum fetuin-B concentrations in obese subjects. Comp Clin Pathol 25, 525–530 (2016). https://doi.org/10.1007/s00580-015-2217-6

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