Comparative Clinical Pathology

, Volume 26, Issue 2, pp 287–290 | Cite as

A mini review of histological and genetic oral lesions in adult and elderly patients referred to Shiraz Dentistry School

  • Janan Ghapanchi
  • Mostafa Rezaie
  • Reza Derafshi
Review Article


Oral diseases include all lesions which affect the oral cavity, periodontal areas and related structures and are associated with pain and discomfort, eating difficulties and problems with speech and communication. Therefore, familiarity with these diseases is necessary for dentists and clinicians. Over the past several decades, long-term outcomes associated with oral lesions and their management has been of increasing concern and dentists must be familiar with these pathological, histological and genetic lesions and how to manage them. This article is a mini review of some common oral lesions especially in adults and elderly patients who attended Shiraz Dentistry School, Iran, and is designed to help all dental practitioners to be more ready to deal with these lesions.


Oral lesions Genetics Halitosis Oral lichen planus 


Compliance with ethical standards

This study was a mini review and was not funded by any grants. Also, this article does not contain any studies with human participants or animals performed by any of the authors.

Conflict of interest

The authors declare that they have no competing interests.


  1. Aggarwal VR, McBeth J, Zakrzewska JM, Lunt M, Macfarlane GJ (2006) The epidemiology of chronic syndromes that are frequently unexplained: do they have common associated factors? Int J Epidemiol 35:468–476CrossRefPubMedGoogle Scholar
  2. Belenguer-Guallar I, Jiménez-Soriano Y, Claramunt-Lozano A (2014) Treatment of recurrent aphthous stomatitis. A literature review. J Clin Exp Dent 6:e168CrossRefPubMedPubMedCentralGoogle Scholar
  3. Bell GW, Smith GLF, Rodgers JM, Flynn RW, Malone CH (2008) Patient choice of primary care practitioner for orofacial symptoms. Br Dent J 204:669–673CrossRefPubMedGoogle Scholar
  4. Benoliel R, Birman N, Eliav E, Sharav Y (2008) The International Classification of Headache Disorders: accurate diagnosis of orofacial pain? Cephalalgia 28:752–762CrossRefPubMedGoogle Scholar
  5. Effiom OA, Adeyemo WL, Soyele OO (2011) Focal reactive lesions of the gingiva: an analysis of 314 cases at a tertiary health institution in Nigeria. Niger Med J 52:35PubMedPubMedCentralGoogle Scholar
  6. Eisen D (2000) Disorders of pigmentation in the oral cavity. Clin Dermatol 18:579–587CrossRefPubMedGoogle Scholar
  7. Farzin M, Mardani M, Ghabanchi J, Fattahi MJ, Rezaee M, Heydari ST, Andisheh Tadbir A (2012) Serum level of matrix metalloproteinase-3 in patients with oral lichen planus. Iranian Red Crescent Med J 14Google Scholar
  8. Ghabanchi J, Andisheh Tadbir A, Darafshi R, Sadegholvad M (2011) The prevalence of median rhomboid glossitis in diabetic patients: a case-control study. Iranian Red Crescent Med J 13Google Scholar
  9. Ghapanchi J, Moattari A, Andisheh Tadbir A (2011) The in vitro anti-viral activity of honey on type 1 herpes simplex virus. Aust J Basic Appl Sci 5:849–852Google Scholar
  10. Ghapanchi J, Darvishi M, Andisheh Tadbir A, Derafshi R, Jokar S (2012a) Prevalence of oral pigmented lesions: a prospective study. Aust J Basic Appl Sci 6:417–420Google Scholar
  11. Ghapanchi J, Darvishi M, Mardani M, Sharifian N (2012b) Prevalence and causes of bad breath in patients attended Shiraz Dentistry School. A cross sectional study. Elixir Human Physio 53:12051–12054Google Scholar
  12. Ghapanchi J, Rezaee M, Bezaie M, Kjhalili S (2013) Prevalence of tongue abnormalities in dental outpatient of Shiraz dental school. Elixir Dentistry 57:14221-14223Google Scholar
  13. Ghapanchi J, Rezaee M, Kamali F, Lavaee F, Shakib E (2014) Prevalence of oral and craniofacial manifestations of hematological dyscrasias at Shiraz Nemazee Hospital Middle East. J Cancer 5:145–149Google Scholar
  14. Gonsalves WC, Chi AC, Neville BW (2007) Common oral lesions: part I. Superficial mucosal lesions. Am Fam Physician 75:501–507PubMedGoogle Scholar
  15. Huber MA (2006) A review of premalignant oral conditions. Tex Dent J 123:502–509PubMedGoogle Scholar
  16. Loesche WJ, Kazor C, Loesche WJ, Kazor C (2002) Microbiology and treatment of halitosis. Periodontol 28:256–279CrossRefGoogle Scholar
  17. Pourshahidi S, Fakhri F, Ebrahimi H, Fakhraei B, Alipour A, Ghapanchi J, Farjadian S (2012) Lack of association between Helicobacter pylori infection and oral lichen planus. Asian Pac J Cancer Prev 13:1745–1747CrossRefPubMedGoogle Scholar
  18. Reddy V, Saxena S, Saxena S, Reddy M (2012) Reactive hyperplastic lesions of the oral cavity: a ten year observational study on north Indian population. J Clin Exp Dent 4:e136CrossRefPubMedPubMedCentralGoogle Scholar
  19. Regezi JA, Sciubba JJ, Jordan RCK (2012) Oral pathology: clinical pathologic correlations. Elsevier Health Sciences, St. Louis, Missouri, USAGoogle Scholar
  20. Rosenberg M (2002) The science of bad breath. Sci Am 286:72–79CrossRefPubMedGoogle Scholar
  21. Shankland WE (2000) Differential diagnosis of two disorders that produce common orofacial pain symptoms. Gen Dent 49:150–155Google Scholar
  22. Shukla P, Dahiya V, Kataria P, Sabharwal S (2014) Inflammatory hyperplasia: from diagnosis to treatment. J Indian Soc Periodontol 18:92–94. doi: 10.4103/0972-124X.128252 CrossRefPubMedPubMedCentralGoogle Scholar
  23. Wirz S, Ellerkmann RK, Buecheler M, Putensen C, Nadstawek J, Wartenberg HC (2010) Management of chronic orofacial pain: a survey of general dentists in German University hospitals. Pain Med 11:416–424CrossRefPubMedGoogle Scholar
  24. Zakrzewska JM, Hamlyn PJ (1999) Facial pain. In: Crombie IK (ed) Epidemiology of pain: a report of the task force on epidemiology of the International Association for the Study of Pain. IASP Press, Seattle, pp 171–202Google Scholar
  25. Zhang W, Chen Y, An Z, Geng N, Bao D (2007) Reactive gingival lesions: a retrospective study of 2,439 cases. Quintessence Int 38:103–110PubMedGoogle Scholar

Copyright information

© Springer-Verlag London 2015

Authors and Affiliations

  • Janan Ghapanchi
    • 1
  • Mostafa Rezaie
    • 1
  • Reza Derafshi
    • 2
  1. 1.Department of Oral and Maxillofacial Medicine, School of DentistryShiraz University of Medical SciencesShirazIran
  2. 2.Department of Prostodontics, School of DentistryShiraz University of Medical SciencesShirazIran

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