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Impact of cellular CD71 (transferrin receptor 1) expression in Egyptian acute leukemia: correlation with clinicopathologic features

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Abstract

Cellular transferrin receptor 1 (CD71) has been identified as a proliferation marker. Inferior outcome with higher expression was observed in many solid tumors. This study objected to assess the expression of CD71 in patients with acute leukemia and to address its prognostic significance and relations to clinicopathologic features. The study included 34 acute myeloid leukemia (AML) and 64 acute lymphoblastic leukemia (ALL) newly diagnosed cases from Mansoura Oncology Center. CD71 was analyzed on blast cells by flow cytometry. CD71 expression was significantly elevated in both AML and ALL. Antigen expression apparently increased in T-ALL, while in AML there was a trend toward a gradual increase of antigen expression in relation to maturation evidence of myeloid subtypes. CD71 expression correlated positively with total leukocyte count in ALL cases and negatively with platelet count in AML cases. In ALL, higher CD71 expression was associated with higher relapse rate and was an independent prognostic factor of overall survival (HR 1.8; 95 % CI 1.2–4.1). In conclusion, CD71 is overexpressed in acute leukemia; it predicts adverse clinical outcome in ALL. In addition, CD71 antagonism could be a possible therapeutic target in acute leukemia.

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Acknowledgments

We would like to thank Dr. Mohammed Awad for his effort in statistical analysis and valuable discussion.

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Authors and Affiliations

  1. Clinical Pathology Department, Hematology unit, Faculty of Medicine, Mansoura University, El-Gomhoria street, Mansoura, Egypt

    Nadia El-Menshawy & Sherin M. Abd-Aziz

  2. Medical Oncology, Faculty of Medicine, Mansoura University Cancer Institute, Mansoura, Egypt

    Mohammed A. Ebrahim

  3. Internal Medicine, Specialized Medicine Mansoura Hospital, Mansoura University, Mansoura, Egypt

    Nader El-Malky

Authors
  1. Nadia El-Menshawy
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  2. Sherin M. Abd-Aziz
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  3. Mohammed A. Ebrahim
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  4. Nader El-Malky
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Correspondence to Nadia El-Menshawy.

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The authors declare that they have no competing interests.

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Informed consent was obtained from all individual participants included in the study. This article does not contain any studies with human or participants or animal performed by any of the authors.

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The study was conducted according to institutional ethical standards.

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This research did not receive funding from any authority.

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El-Menshawy, N., Abd-Aziz, S.M., Ebrahim, M.A. et al. Impact of cellular CD71 (transferrin receptor 1) expression in Egyptian acute leukemia: correlation with clinicopathologic features. Comp Clin Pathol 25, 511–518 (2016). https://doi.org/10.1007/s00580-015-2213-x

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  • DOI: https://doi.org/10.1007/s00580-015-2213-x

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