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The influence of carob powder on lipid profile and histopathology of some organs in rats


The present study aimed to investigate the effect of two levels of carob powder 10 and 20 % on lipid profile. Forty male Sprague–Dawley rats were divided into two groups. The first group was fed on a basal diet and acts as a control group. The second group was fed on a hyperlipidemic diet (a basal diet plus 10 % animal fat and 1 % cholesterol). After 6 weeks, the second group was divided into three even subgroups: subgroup 1 was fed on a hyperlipidemic diet, subgroup 2 was fed on a hyperlipidemic diet plus 10 % carob powder, and subgroup 3 was fed on a hyperlipidemic diet plus 20 % carob powder. At the end of the experimental period, serum samples were collected to measure total cholesterol (TC), triglyceride (TG), high-density lipoproteins (HDL), low-density lipoproteins (LDL), and very-low-density lipoproteins (VLDL). Heart and kidney samples were taken for histopathological examination. The obtained results revealed that feeding rats with 10 and 20 % carob powder improved lipid profile parameters and histopathological characteristics in the heart and kidney of experimental rats.

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Correspondence to Khaled M. A. Hassanein.

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Hassanein, K.M.A., Youssef, M.K.E., Ali, H.M. et al. The influence of carob powder on lipid profile and histopathology of some organs in rats. Comp Clin Pathol 24, 1509–1513 (2015).

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  • Carob powder
  • Rats
  • Lipid profile
  • Histopathology
  • Kidney
  • Heart