The present study aimed to investigate the effect of two levels of carob powder 10 and 20 % on lipid profile. Forty male Sprague–Dawley rats were divided into two groups. The first group was fed on a basal diet and acts as a control group. The second group was fed on a hyperlipidemic diet (a basal diet plus 10 % animal fat and 1 % cholesterol). After 6 weeks, the second group was divided into three even subgroups: subgroup 1 was fed on a hyperlipidemic diet, subgroup 2 was fed on a hyperlipidemic diet plus 10 % carob powder, and subgroup 3 was fed on a hyperlipidemic diet plus 20 % carob powder. At the end of the experimental period, serum samples were collected to measure total cholesterol (TC), triglyceride (TG), high-density lipoproteins (HDL), low-density lipoproteins (LDL), and very-low-density lipoproteins (VLDL). Heart and kidney samples were taken for histopathological examination. The obtained results revealed that feeding rats with 10 and 20 % carob powder improved lipid profile parameters and histopathological characteristics in the heart and kidney of experimental rats.
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Hassanein, K.M.A., Youssef, M.K.E., Ali, H.M. et al. The influence of carob powder on lipid profile and histopathology of some organs in rats. Comp Clin Pathol 24, 1509–1513 (2015). https://doi.org/10.1007/s00580-015-2108-x
- Carob powder
- Lipid profile