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The effect of caraway (Carum carvi L.) on the blood antioxidant enzymes and lipid peroxidation in streptozotocin-induced diabetic rats

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Abstract

Different studies have shown that oxidative stress has an important role in both types of diabetes mellitus. The aim of this study was to evaluate the effect of different doses of Carum carvi oil on antioxidant enzymes of streptozotocin-induced diabetic rats. Fifty-six Wistar male rats weighing between 250 ± 50 g were divided into seven equal groups. Diabetes was induced in the experimental rats with streptozotocin (60 mg kg−1 body weight). Rats in group I served as the normal control animals; group II served as the caraway control, whereas group III served as the diabetic control and group IV was the diabetic control which received sunflower oil. Groups V to VII were the test groups receiving various oral doses of caraway oil (5, 10, and 20 mg kg−1 body weight, respectively). The experiment lasted for a period of 30 days, and the following antioxidant enzymes were assayed: SOD, GSH-Px, CAT, and MDA. The results showed that rats receiving Carum carvi oil gained significantly more weight and had a lower level of blood glucose (P < 0.05) compared to the controls. In addition, activity of MDA was decreased, and the activities of SOD, GSH-Px, and CAT were significantly high (P < 0.05) in the test groups administered black caraway oil. It is concluded that caraway seed oil can be effective in reducing oxidative stress in diabetes mellitus.

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Acknowledgments

The authors would like to thank the Research Council of Shiraz University and School of Veterinary Medicine, Shiraz University for financial and technical support of this study (Grant No. 71-GR-VT-5).

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Correspondence to Saeed Nazifi.

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Erjaee, H., Rajaian, H., Nazifi, S. et al. The effect of caraway (Carum carvi L.) on the blood antioxidant enzymes and lipid peroxidation in streptozotocin-induced diabetic rats. Comp Clin Pathol 24, 1197–1203 (2015). https://doi.org/10.1007/s00580-014-2060-1

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