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MDR1 polymorphisms (G2677T and C3435T) in B-chronic lymphocytic leukemia

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Abstract

The human multidrug resistance (MDR1) gene encodes P-glycoprotein, which affects the pharmacokinetics of many drugs. We investigated whether common MDR1 single-nucleotide polymorphisms (C3435T and G2677T) affect predisposition to B-chronic lymphocytic leukemia (B-CLL). Genotyping was performed in 65 patients with CLL and in 70 controls using polymerase chain reaction—restriction fragment length polymorphism. We observed a higher frequency of carriers of 3435CT gene among B-CLL patients as compared to normal individuals (58.5 vs. 22.9 %, p = <0.001). The genotype 3435CT was associated with B-CLL [odds ratio = 4.8, 95 % confidence interval = 2.3–10.0]. Moreover, patient and control groups did not differ significantly regarding the MDR1 genotype (G2677T). Furthermore, no correlation was shown between the MDR1 (3435 or 2677) genotypes and clinical and laboratory data of patient group. These data indicate that MDR1 C3435T single-nucleotide polymorphism may carry an increased risk of developing B-CLL.

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Authors and Affiliations

  1. Clinical Pathology Department, Faculty of Medicine, Cairo University, Cairo, 11654, Egypt

    Saher K. Elden Hussien, Asmaa Ahmed Abdel-Aal & Reham A. Aleem Afify

  2. El Kasr El Aini, Cairo, 11654, Egypt

    Reham A. Aleem Afify

  3. Clinical Haematology Unit, Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, 11654, Egypt

    Noha El-Husseiny

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  1. Saher K. Elden Hussien
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  2. Asmaa Ahmed Abdel-Aal
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  3. Reham A. Aleem Afify
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  4. Noha El-Husseiny
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Correspondence to Reham A. Aleem Afify.

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Hussien, S.K.E., Abdel-Aal, A.A., Afify, R.A.A. et al. MDR1 polymorphisms (G2677T and C3435T) in B-chronic lymphocytic leukemia. Comp Clin Pathol 23, 119–124 (2014). https://doi.org/10.1007/s00580-012-1581-8

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  • DOI: https://doi.org/10.1007/s00580-012-1581-8

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