Skip to main content

The effect of naturally occurring renal insufficiency on serum pancreatic-specific lipase in cats


Feline pancreatitis is a common but likely an under-diagnosed condition. The recent development of pancreatic-specific lipase testing for this species has resulted in improved diagnostic testing. In cats, the effect of renal insufficiency has not been adequately evaluated. This paper reveals increased pancreatic-specific lipase in cats with renal insufficiency, but not pre-renal azotaemia, and suggests a significant effect of renal insufficiency on serum pancreatic-specific lipase concentrations.

This is a preview of subscription content, access via your institution.

Fig. 1


  • Allen HS, Steiner J, Broussard J, Mansfield C, Williams DA, Jones B (2006) Serum and urine concentrations of trypsinogen-activation peptide as markers for acute pancreatitis in cats. Can J Vet Res 70:313–316

    PubMed  CAS  Google Scholar 

  • Collen MJ, Ansher AF, Chapman AB, Mackow RC, Lewis JH (1990) Serum amylase in patients with renal insufficiency and renal failure. Am J Gastroenterol 85:1377–1380

    PubMed  CAS  Google Scholar 

  • De Cock HEV, Forman MA, Farver TB, Marks SL (2007) Prevalence and histopathologic characteristics of pancreatitis in cats. Vet Pathol 44:39–49

    PubMed  Article  Google Scholar 

  • Forman MA, Marks SL, De Cock HEV, Hergesell EJ, Wisner ER, Baker TW, Kass PH, Steiner JM, Williams DA (2004) Evaluation of serum feline pancreatic lipase immunoreactivity and helical computed tomography versus conventional testing for the diagnosis of feline pancreatitis. J Vet Intern Med 18:807–815

    PubMed  Article  CAS  Google Scholar 

  • Jaensch S (2012) Associations between serum amylase, lipase and pancreatic specific lipase in dogs. Comp Clin Pathol 21(2):157–160

    Google Scholar 

  • Jiang CF, Ng KW, Wu CS, Chen HC, Liang CT, Chen YH (2002) Serum level of amylase and lipase in various stages of chronic renal insufficiency. Zhonghua Yi Xue Za Zhi (Taipei) 65:49–54

    Google Scholar 

  • Larson MM, Panciera DL, Ward DL, Steiner JM, Williams DA (2005) Age-related changes in the ultrasound appearance of the normal feline pancreas. Vet Radiol Ultra 46:238–242

    Article  Google Scholar 

  • Lee SY, Lee KT, Moon W, Lee SS, Hwang JY, Lee JK, Paik SW, Rhee JC (2005) Pancreatic enzyme elevations in Korean chronic renal failure patients. Korean J Gastroenterol 45(2):125–129

    PubMed  Google Scholar 

  • Masoero G, Bruno M, Colaferro S, Cosseddu D, Vacha GM (1996) Increased serum pancreatic enzymes in uremia: relation with treatment modality and pancreatic involvement. Pancreas 13:350–355

    PubMed  Article  CAS  Google Scholar 

  • Saunders HM, Van Winkle TJ, Drobatz K, Kimmel SE, Washabau RJ (2002) Ultrasonographic findings in cats with clinical, gross pathologic, and histologic evidence of acute pancreatic necrosis: 20 cases (1994–2001). JAVMA 221:1724–1730

    PubMed  Article  Google Scholar 

  • Schweighauser A, Gaschen F, Steiner J, Allenspach K, Francey T, Gaschen L (2009) Evaluation of endosonography as a new diagnostic tool for feline pancreatitis. J Fel Med Surg 11:492–498

    Article  Google Scholar 

  • Stanescu A, Mayer D, Rosenthal J, Malfertheiner P (1990) Effect of chronic renal failure and hemodialysis on the pancreas-specific enzyme pattern in the serum. Leber Magen Darm 2:83–89

    PubMed  CAS  Google Scholar 

  • Xenoulis P, Steiner JM (2008) Current concepts in feline pancreatitis. Topics in Comp Animal Med 23:185–192

    Article  Google Scholar 

  • Zoran DL (2006) Pancreatitis in cats: diagnosis and management of a challenging disease. JAAHA 42:1–9

    Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Susan Jaensch.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Jaensch, S. The effect of naturally occurring renal insufficiency on serum pancreatic-specific lipase in cats. Comp Clin Pathol 22, 801–803 (2013).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:


  • Pancreatic-specific lipase
  • Renal insufficiency
  • Pancreatitis
  • Feline