Effect of exposure to perfluorooctanoic acid on hepatic antioxidants in mice

Comparative Clinical Pathology volume 21, pages1643–1645(2012)Cite this article

Abstract

The present study was undertaken to evaluate hepatic antioxidants status in female mice after exposure to perfluorooctanoic acid (PFOA). A total number of 20 female mice were subjected to the study; out of them, 15 mice were treated with PFOA. PFOA solutions were prepared at 0.1, 0.5, and 1 mg/ml of deionized water and administered to the mice by gavage once daily for 3 weeks at a volume of 10 ml/kg. Controls (five mice) received an equivalent volume of deionized water. The results revealed significant increase in liver weight at dose of 5 (p < 0.01) and 10 mg/kg body weight (b.w., p < 0.01). Both hepatic total glutathione level and hepatic catalase activity were significantly increased (p < 0.01) at dose of 5 mg/kg b.w. On the other hand, hepatic glutathione reductase activity was significantly increased at dose of 10 mg/kg b.w. In this model system, PFOA administration was effective in inducing oxidative stress particularly reflected in the liver.

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Affiliations

  1. Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Assiut University, Assiut, 71526, Egypt

    Doha Yahia Ahmed

  2. Department of Animal Medicine, Faculty of Veterinary Medicine, Assiut University, Assiut, 71526, Egypt

    Mahmoud R. Abd Ellah

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  1. Doha Yahia Ahmed
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  2. Mahmoud R. Abd Ellah
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Correspondence to Mahmoud R. Abd Ellah.

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Ahmed, D.Y., Abd Ellah, M.R. Effect of exposure to perfluorooctanoic acid on hepatic antioxidants in mice. Comp Clin Pathol 21, 1643–1645 (2012). https://doi.org/10.1007/s00580-011-1341-1

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Keywords

  • PFOA
  • Mice
  • Antioxidants
  • Liver