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Serum chromium levels in Egyptian diabetic patients

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Abstract

A direct association between trace elements and human disease has been observed. The alteration of chromium metabolism has been observed in diabetic patients. The aim of this study was to investigate any association between serum chromium levels and diabetes mellitus in the Egyptian population. Thirty patients with type 2 diabetes were compared to 20 healthy age- and sex-matched control subjects as regards serum chromium levels (measured on atomic absorption spectrometry), fasting and postprandial blood glucose, HbA1C, T.C., T.G., HDL-C, and LDL-C. Serum chromium levels were significantly lower in diabetic patients than in the control subjects (p = 0.035). There was a significant increase in T.C., T.G., and LDL-C in the patient group than the control group (p = 0.000, p = 0.000, and p = 0.000, respectively). A negative correlation was observed between serum chromium level on one hand and HbA1C (p = 0.043), T.C. (p = 0.01), T.G. (p = 0.021), and LDL-C (p = 0.005) on the other hand. Chromium seems to be implicated in the metabolism of blood glucose and lipid profile.

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References

  • Akhuemokhan K, Eregie A, Fasanmade OA (2010) Trace mineral status and glycaemic control in Nigerians with type 2 diabetes. Afr J Diabet Med 18:20–22

    Google Scholar 

  • Alissa EM, Bahjri SM, Ahmed WH, Al-Ama N, Ferns GA (2009) Chromium status and glucose tolerance in Saudi men with and without coronary artery disease. Biol Trace Elem Res 131:215–228

    Article  PubMed  CAS  Google Scholar 

  • Allain C, Poon L, Chan C et al (1974) Enzymatic determination of total serum cholesterol. Clin Chem 20:470–475

    PubMed  CAS  Google Scholar 

  • Anderson RA, Cheng N, Bryden NA, Polansky MM, Cheng N, Chi J, Feng J (1997) Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. Diabetes 46:1786–1791

    Article  PubMed  CAS  Google Scholar 

  • Anderson R, Cefalu W, Jeejeebhoy K, Kaats G (2002) Role of chromium in glucose intolerance, diabetes, total parenteral nutrition, and body composition. Chemistry and materials science. Trace Elem Man Anim 10 2002, III, Part 1, 503–509. doi:10.1007/0-306-47466-2_160

  • Cefalu WT, Hu FB (2004) Role of Chromium in Human Health and in Diabetes Diabetes Care. 2004,vol. 27 no. 11 2741–2751

  • Chalmers KH (2005) Medical nutrition therapy. In: Kahn CR et al (eds) Joslin's diabetes mellitus, 14th edn. Philadelphia, Lippincott Williams and Wilkins, pp 611–629

    Google Scholar 

  • Chen WY, Chen C-J, Liu C-H, Mao FC (2009) Chromium supplementation enhances insulin signalling in skeletal muscle of obese KK/HlJ diabetic mice. Diabetes Obes Metab 11:293–303

    Article  PubMed  CAS  Google Scholar 

  • Chinyere NA, Opara UCA, Henrieta EM, Nathaniel UI (2005) Serum and urine levels of chromium and magnesium in type 2 diabetics in Calabar, Nigeria. Mal J Nutr 11(2):133–142

    Google Scholar 

  • Di Bona K, Love S, Rhodes N, DeAna McAdory D, Sinha S, Kern N, Kent J, Strickland J, Wilson A, Beaird J et al (2011) 6-Chromium is not an essential trace element for mammals: effects of a “low-chromium” diet. J Biol Inorg Chem 16(3):381–390

    Article  PubMed  Google Scholar 

  • Ding W, Chai Z, Duan P, Feng W, Qian Q (1998) Serum and urine chromium concentrations in elderly diabetics. Biol Trace Elem Res 63:231–237

    Article  PubMed  CAS  Google Scholar 

  • Ekmekcioglu C, Prohaska C, Pomazal K, Steffan I, Schernthaner G, Marktl W (2001) Concentrations of seven trace elements in different hematological matrices in patients with type 2 diabetes as compared to healthy controls. Biol Trace Elem Res 79:205–219

    Article  PubMed  CAS  Google Scholar 

  • Fossati P, Prencipe L (1982) Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin Chem 28(10):2077–2080

    PubMed  CAS  Google Scholar 

  • Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499–502

    PubMed  CAS  Google Scholar 

  • Gunton JE, Hams G, Hitchman R, McElduff A (2001) Serum chromium does not predict glucose tolerance in late pregnancy1,2. Am J Clin Nutr 73:99–104

    PubMed  CAS  Google Scholar 

  • Hamad A, Krishan MM, Qassem MJ, Mazahren AS (2009) The effect of chromium glycinate on the blood glucose control and blood lipids of normal and diabetic patients. Pakistani J Nutr 8(6):900–904

    Article  CAS  Google Scholar 

  • Jeejeebhoy KN, Chu RC, Marliss EB, Greenberg GR, Bruce-Robertson A (1977) Chromium deficiency, glucose intolerance, and neuropathy reversed by chromium supplementation, in a patient receiving long-term total parental nutrition. Am J Clin Nutr 30:531–538

    PubMed  CAS  Google Scholar 

  • Kayne F, Kumar G, Laboda H et al (1978) Atomic absorption spectrophotometry of chromium in serum and urine with a modified Perkin-Elmer603 atomic absorption spectrophotometer. Clin Chem 24(12):2151–2154

    PubMed  CAS  Google Scholar 

  • Kazi TG, Afridi HI, Kazi N, Jamali MK, Arain MB, Jalbani N, Kandhro GA (2008) Copper, chromium, manganese, iron, nickel, and zinc levels in biological samples of diabetes mellitus patients. Biol Trace Elem Res 122:1–18

    Article  PubMed  CAS  Google Scholar 

  • Kleefstra N, Houweling ST, Jansman FG et al (2006) Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care 29:521–525

    Article  PubMed  CAS  Google Scholar 

  • Morris BW, MacNeil S, Hardisty CA, Heller S, Burgin C, Gray TA (1999) Chromium homeostasis in patients with type II (NIDDM) diabetes. J Trace Elem Med Biol 13:57–61

    Article  PubMed  CAS  Google Scholar 

  • Muula A (2000) Preventing diabetes associated morbidity and mortality in resource poor communities. Diabetes Int 10:47–48

    Google Scholar 

  • Racek J, Trefil L, Rajdl D, Mudrova V, Hunter D, Senft V (2006) Influence of chromium-enriched yeast on blood glucose and insulin variables, blood lipids, and markers of oxidative stress in subjects with type 2 diabetes mellitus. Biol Trace Elem Res 109(3):215–230

    Article  PubMed  CAS  Google Scholar 

  • Sahin K, Onderci M, Tuzcu M, Ustundag B, Cikim G, Ozercan IH, Sriramoju V, Juturu V, Komorowski JR (2007) Effect of chromium on carbohydrate and lipid metabolism in a rat model of type 2 diabetes mellitus: the fat-fed, streptozotocin-treated rat. Metabolism 56:1233–1240

    Article  PubMed  CAS  Google Scholar 

  • SPSS (1999) Statistical package for social science. Standard version 10.0.5. SPSS, Chicago

    Google Scholar 

  • Trinder P (1969) Determination of blood glucose using 4-aminophenazone. J Clin Path 22:246

    Article  PubMed  CAS  Google Scholar 

  • Warnick G, Mayfield C, Benderson J et al (1982) HDL cholesterol quantitation by phosphotungstate-Mg2+ and by dextran sulfate-Mn2+-polyethylene glycol precipitation, both with enzymic cholesterol assay compared with the lipid research method. Am J Clin Pathol 78(5):718–723

    PubMed  CAS  Google Scholar 

  • Zima T, Mestek O, Tesar V, Tesarova P, Nemecek K, Zak A, Zeman M (1998) Chromium levels in patients with internal diseases. Biochem Mol Biol Int 46:365–374

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt

    Asmaa Ismail Ahmed

  2. Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt

    Manal Mahmoud Helal

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  1. Asmaa Ismail Ahmed
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  2. Manal Mahmoud Helal
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Correspondence to Asmaa Ismail Ahmed.

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Ahmed, A.I., Helal, M.M. Serum chromium levels in Egyptian diabetic patients. Comp Clin Pathol 21, 1373–1377 (2012). https://doi.org/10.1007/s00580-011-1299-z

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