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Effect of methanolic extract of Mucuna pruriens seed on the immune response of mice

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Abstract

The effect of the methanolic extract of Mucuna pruriens seed was evaluated in mice with regards to delayed hypersensitivity reaction (DTR), primary and secondary antibody response and in vivo inflammatory leucocyte mobilization. The extract at 250 and 500 mg/kg produced significant (p < 0.05) inhibition of DTR in mice by 33.33% and 28.89%, respectively. The extract caused elevation of secondary SRBCs-specific antibody titre with antibody response being significantly (p < 0.05) increased at 250 and 500 mg/kg when compared with control. The extract at 250 and 500 mg/kg increased leucocyte mobilization significantly (p < 0.05) when compared with the control and levamisole-treated groups. At 100 mg/kg, the mobilization did not differ with the levamisole-treated group but was significantly (p < 0.05) higher than the control. The leucocyte mobilization was more of neutrophils than lymphocytes. The ability of the extract to inhibit the DTR, increase secondary antibody response and in vivo leucocyte mobilization was an indication that the extract probably influenced immune response in mice.

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  1. Department of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria

    James Ifeanyichukwu Eze & Sunday Ndukwe

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  1. James Ifeanyichukwu Eze
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  2. Sunday Ndukwe
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Correspondence to James Ifeanyichukwu Eze.

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Eze, J.I., Ndukwe, S. Effect of methanolic extract of Mucuna pruriens seed on the immune response of mice. Comp Clin Pathol 21, 1343–1347 (2012). https://doi.org/10.1007/s00580-011-1294-4

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  • DOI: https://doi.org/10.1007/s00580-011-1294-4

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