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Modulatory effect of Semecarpus anacardium against oxidative damages in DMBA-induced mammary carcinogenesis rat model

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Abstract

Oxidative stress resulting from increased free radical generation plays an important role in carcinogenesis. The present study investigates the therapeutic efficacy of Semecarpus anacardium Linn nut milk extract (SA) against lipid peroxidation (LPO) and antioxidant status in spleen and thymus of experimental animals. Adult female albino rats of Sprague–Dawley strain weighing 170–190 g were used for the study and were divided into four groups. Group I control animals received standard pellet diet and water ad libitum. Group II rats were induced with 7,12-dimethyl benz[a]anthracene (DMBA) (25 mg in 1 ml olive oil) by gastric incubation, whereas another set of DMBA-induced rats were treated with SA (200 mg/kg body weight/day) in olive oil orally by gastric incubation for 14 days (group III). Group IV rats served as SA-treated control animals. At the end of the experimental period, the rats were anaesthetised and killed. Organs like spleen and thymus were isolated and used for biochemical measures and histology studies. In cancer condition, the LPO was increased and antioxidant levels were decreased in the spleen and thymus of cancer-induced rats. Treatment with SA decreased LPO and increased antioxidant status in rats induced with DMBA. The results obtained depict the potency of drug’s antioxidant property by depleting lipid peroxide levels in spleen and thymus and thus its role in enhancing the immune function.

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  1. Department of Medical Biochemistry, DR. A.L.M. P-G. I.B.M.S, University of Madras, Taramani Campus, Chennai, 600 113, India

    Haseena Banu Hedayathullah Khan, Kaladevi Siddhi Vinayagam, Priya Madan & Sachdanandam Panchanatham

  2. Department of Pathology, DR. A.L.M. P-G. I.B.M.S, University of Madras, Taramani Campus, Chennai, 600 113, India

    Shanthi Palanivelu

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  1. Haseena Banu Hedayathullah Khan
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Khan, H.B.H., Vinayagam, K.S., Madan, P. et al. Modulatory effect of Semecarpus anacardium against oxidative damages in DMBA-induced mammary carcinogenesis rat model. Comp Clin Pathol 21, 1275–1284 (2012). https://doi.org/10.1007/s00580-011-1278-4

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